Clinical trials: Obese Diabetics
Childhood Obesity
Criticality Analysis of Diabetic Gait Within a Primary Care Pediatric Clinic for Obese Children (PAIDOS)
One of the difficulties with diabetes care is the problem of predicting progression to more severe stages using current measures (for example blood glucose, HbA1c).
- Trial name
- PAIDOS (NCT03943108)
- Testing
- Gait analysis
- Where
- Mexico
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr Salvador Villalpando-Carrion
Diabetes Mellitus, Obesity
An Ascending Multi-Dose, Tolerance and Pharmacokinetic Study in Obese or Overweight Type 2 Diabetic Volunteers
The purpose of this study is to evaluate the safety and tolerance of multiple intravenous (through a vein) doses of trodusquemine (MSI-1436) in obese or overweight, type 2 diabetics.
- Trial name
- NCT00806338
- Testing
- Trodusquemine (MSI-1436)
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Genaera Corporation
Insulin Resistance, Abdominal Obesity
High Intensity Interval Versus Focused Ultrasound on Insulin Resistance in Diabetics With Abdominal Obesity
Obesity and diabetes share a common insulin resistance pathway and contribute to chronic hyperglycemia. Both high-intensity interval exercise (HIIE) and focused ultrasound (FUS) have been explored in the context of managing…
- Conditions
- Insulin Resistance, Abdominal Obesity, Diabetes
- Trial name
- diabetic (NCT06376955)
- Testing
- High intensity interval exercise, Focused ultrasound
- Volunteers
- 40 people
- Sponsor
- Badr University
Type 2 Diabetes Mellitus
Study of VI-0521 Compared to Placebo in the Glycemic Management of Obese Diabetics
The purpose of this study is to evaluate the efficacy and safety of VI-0521 compared to placebo in the glycemic management of obese diabetic adults.
- Trial name
- NCT00486291
- Testing
- VI-0521
- Where
- 9 sites in United States
- Volunteers
- 210 people
- Sponsor
- VIVUS LLC
Diabetic Nephropathies
MRI Biomarkers in Diabetic Kidney Disease
Diabetic kidney disease is one of the most severe and frequent complications of diabetes. Few preclinical markers are available apart from plasma creatinine and microalbuminuria.
- Trial name
- MR3T - DKD (NCT04570735)
- Testing
- MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Obesity, Type 2 Diabetes Mellitus
Surgical Treatment in Diabetic Patients With Grade 1 Obesity
There will be a randomized clinical trial, non-blind, 3-arm treatment (medical, surgical, gastric bypass and ileal transposition surgery with and sleeve), which will be conducted in a single center - S.B.S.
- Trial name
- NCT01857076
- Testing
- Gastric bypass surgery, Surgical ileal transposition with sleeve, Clinical
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Hospital Sirio-Libanes
Binge-Eating Disorder, Eating Disorders
Genetic Association of Glucocorticoid Receptor Gene Polymorphisms With Binge Eating
The aim of the present study was to specifically screen obese diabetic adolescent female individuals for BED, checking the variants of the GR gene (rs56149945; rs41423247) amongst identified individuals, and this led to assessing…
- Conditions
- Binge-Eating Disorder, Eating Disorders, Obesity, Diabetes Type 2
- Trial name
- NCT04786054
- Testing
- BED Questionnaire
- Where
- Pakistan
- Volunteers
- 91 people
- Sponsor
- Corporacion Parc Tauli
Diabetes Mellitus, Obesity
Investigating Muscle Failure in Diabetic Myopathy
The goal of this observational study is to assess if diabetes and obesity are independently related to functional and structural muscle deficits, and how muscular deficits relate to metabolic properties of diabetes and obesity.
- Conditions
- Diabetes Mellitus, Obesity, Chronic Hyperglycaemia, Weight Loss
- Trial name
- NCT05685927
- Testing
- 6-months of medically assisted glycemic improvement, Bariatric surgery
- Where
- Denmark
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Neuropathology
Assessment of the Prevalence of Small Fiber Peripheral Neuropathy Among Non-diabetic Obese Patients
Background / rational: Obesity is associated with significant comorbidities including type 2 diabetes (insulin resistance), heart disease, stroke, hypertension, sleep apnea syndrome, dyslipidemia, cancer, hepatobiliary diseases…
- Trial name
- NEUROBISITE (NCT02767583)
- Testing
- Exams
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Obesity, Prediabetes
Effect of Aerobic Exercise Program on Blood Glucose Level and Quality of Life in Pre-diabetic Overweight/Obese Adolescents
PURPOSE: The study aims to: Investigate the effect of the designed aerobic exercise program on the blood glucose level (fasting blood glucose and HbA1C) in overweight/ obese pre-diabetic adolescents.
- Trial name
- NCT06756425
- Testing
- aerobic exercise program, nutritional health awareness sessions
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Obesity
Exploratory Study to Investigate the Effect of Dapagliflozin and Exenatide Combined on Body Weight
Obesity is a medical condition which increases the risk of other diseases, such as type 2 diabetes and cardiovascular disease. Obesity-related risk factors for the development of other metabolic diseases include unstable glucose…
- Trial name
- Dapalost (NCT02313220)
- Testing
- Dapagliflozin, Exenatide
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Type 2 Diabetes, Overweight
Effects of Replacing Diet Beverages With Water on Weight Maintenance of Type 2 Diabetic Obese Women: 18 Months Follow up
the present study aimed to follow up our participants in order to consider the changes in weight and anthropometric measurements after the 12-month weight maintenance as well as the total of 18 months, consisting of the…
- Conditions
- Type 2 Diabetes, Overweight, Obese
- Trial name
- NCT03726762
- Testing
- DBs at the end of the main meal + weight control program, Water at the end of the main meal+ weight control program
- Where
- Iran
- Volunteers
- 81 people
- Sponsor
- Novindiet Clinic
Type 2 Diabetes Mellitus, Obesity
Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes
Type 2 diabetes (T2D) in youth is increasing in prevalence in parallel with the obesity epidemic. In the US, almost half of patients with renal failure have DKD, and ≥80% have T2D.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Bariatric Surgery Candidate, Nephropathy
- Trial name
- IMPROVE-T2D (NCT03620773)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 mg/mL, Vertical Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus Type 2 in Obese, Type 2 Diabetes Mellitus With Features of Insulin Resistance
Percutaneous Electric Neurostimulation of Dermatome T7 Improves Glycemic Profile in Obese and Typo 2 Diabetic Patients
Percutaneous neurostimulation of dermatome T7 increases Insulin segregation by the apancreas and improves glycemic profile in diabetic patients
- Trial name
- NCT02122874
- Testing
- Percutaneous Neurostimulation (PENS) of dermatome T7, 1200 Kcal diet
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Elche
Tear Film Deficiency
Effect of Obesity on Tear Film and Ocular Health Among Diabetic Patients
To evaluate the effect of obesity on tear film and ocular health in diabetic patients. Research Design An observational cross-sectional study will be conducted.
- Trial name
- NCT06913452
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Superior University
Obesity, Dapagliflozin Adverse Reaction
The Effect of Dapagliflozin on Weight Loss in Obese Adults Without Diabetes
The goal of this clinical trial is to examine the effectiveness of a drug named dapagliflozin (tested drug) on weight loss in young adults aged between 18 and 40 years with obesity who are not diagnosed with diabetes.
- Conditions
- Obesity, Dapagliflozin Adverse Reaction, Weight Loss, Effect of Drug
- Trial name
- DAPA-ANDO (NCT06000462)
- Testing
- Dapagliflozin 10mg Tab, Metformin 1000 mg (ttd)
- Where
- Oman
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Oman Ministry of Health
Overweight, Obesity
VDR Gene Polymorphisms and Weight Loss in Non-diabetic Overweight and Obese Subjects
This is a six months intervention study in non-diabetic overweight and obese subjects. Subjects will be counseled for weight loss through diet and exercise.
- Trial name
- NCT03386331
- Testing
- diet and exercise
- Where
- India
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Overweight , Obesity
Phase 2 Study to Evaluate the Efficacy and Safety of MWN109 Injection in Non-Diabetic Participants With Overweight
This study is a multicenter, randomized, double-blind, placebo-controlled phase II study conducted in China. It aims to evaluate the efficacy and safety of MWN109 injection in non-diabetic overweight or obese participants.
- Trial name
- NCT07791537
- Testing
- MWN109 1, MWN109 2, MWN109 3
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
PreDiabetes, Obesity, Morbid
Effectiveness of Dapagliflozin for Weight Loss
Mexico has one of the highest prevalence of obesity, reported on 32.4 percent of people over 20 years old, with a prevalence of obesity class III of 1.8 percent on males and 4.1 percent on females.
- Conditions
- PreDiabetes, Obesity, Morbid, Diabetes Mellitus, Type 2
- Trial name
- NCT03968224
- Testing
- Dapagliflozin/Metformin, Metformin
- Where
- Mexico
- Volunteers
- 160 people
- Sponsor
- Centro Medico Nacional Siglo XXI IMSS
CKD, Diabetic Kidney Disease
Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy
This randomized study evaluates the effect of subcutaneous semaglutide /in combination with lifestyle counseling in patients with type 2 diabetes mellitus (T2DM), overweight/obesity, and stage 4-5 chronic kidney disease (CKD) or…
- Conditions
- CKD, Diabetic Kidney Disease, Type 2 Diabetes Mellitus in Obese, Obesity
- Trial name
- RAISE-KT (NCT04741074)
- Testing
- Semaglutide 2 mg/1.5 ml (1.34 mg/ml), prefilled pen-injector for subcutaneous injection solution
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Geisinger Clinic