Clinical trials: Obese Individuals
Obese
Changes in Intrahepatic Lipids With Exercise
Individuals with obesity and particular type 2 diabetes have abnormally high levels of fat in liver cells and are at increased risk for cardiovascular and liver-related mortality.
- Trial name
- NCT02181270
- Testing
- high intensity exercise, continuous moderate exercise
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Abdominal Obesity
Effects of a Polyphenol-rich Cranberry Extract on Cardiometabolic and Neurocognitive Health
The objective of this double-blind, parallel, randomized placebo-controlled clinical trial is to evaluate the effects of consumption of polyphenol-rich cranberry extract standardized in PACs (36 mg PACs/capsule) on…
- Trial name
- Neurocan (NCT05062954)
- Testing
- Polyphenol-rich cranberry extract supplement standardized in proanthocyanidins
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Laval University
Binge Eating Disorder, Cognitive Therapy/Methods
Psychological Treatment of Overweight Binge Eaters
Cognitive-behavioral therapy (CBT) has documented efficacy for the treatment of binge eating disorder (BED). Interpersonal psychotherapy (IPT) has been shown to reduce binge eating but its long-term impact and time course on…
- Conditions
- Binge Eating Disorder, Cognitive Therapy/Methods, Mental Disorders/Epidemiology, Obesity/Epidemiology
- Trial name
- NCT01208272
- Testing
- Cognitive Behavioral Therapy (CBT), Interpersonal Therapy (IPT)
- Where
- 2 sites in United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Prehypertension, Borderline Dyslipidemia
Smartwatch-based Intervention for Cardiovascular Health (SWITCH)
This study aims to employ a cluster randomized controlled trial to evaluate the effectiveness of an mHealth-Based Multi-faceted Cardiovascular Health Intervention Model among Overweight/Obese Individuals with Cardiometabolic…
- Conditions
- Prehypertension, Borderline Dyslipidemia, Overweight , Obesity, Prediabetes
- Trial name
- NCT07372729
- Testing
- Smartwatch-Based Multi-Faceted Behavioral Intervention Model Led by Exercise and Dietary Interventions, Supported by Primary Medical Staff, Along with the Distribution of Health Education Manuals, Face-to-face health education sessions
- Where
- 3 sites in China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Obesity
Characteristics and Treatment Experiences of Individuals Using Injectable Semaglutide for Weight Management, a Cross-sectional Time-series Analysis, Multi-country Study.
The purpose of this study is to collect information for scientific research and to better understand the experiences of participants managing their weight.
- Trial name
- OUTSTEP-1 (NCT07154238)
- Testing
- No treatment given
- Where
- Germany
- Volunteers
- 2,546 people
- Sponsor
- Novo Nordisk A/S
Metabolic Disease, Cardiovascular Diseases
HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking
This clinical trial investigates whether incorporating stair walking into daily routines improves physical health in adults at risk of lifestyle-related conditions such as hypertension, type 2 diabetes, and cardiovascular…
- Conditions
- Metabolic Disease, Cardiovascular Diseases, Hypertension, Obesity and Overweight
- Trial name
- HYPERWALK (NCT06952348)
- Testing
- Stair and brisk walking combined, Brisk walking, Standard care
- Where
- 4 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Karolinska Institutet
Obesity & Overweight
Effects of Inulin on Cardiometabolic Risk Factors in Individuals Using Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA ) Medications for Weight Loss
The goal of this double-blind randomized placebo-controlled supplement study is to investigate if the supplement of inulin (prebiotics, 10 grams per day) has beneficial effects on cardiometabolic risk factors in overweight or…
- Trial name
- NCT07611552
- Testing
- inulin (prebiotics)
- Where
- 5 sites in China
- Volunteers
- 600 people
- Sponsor
- Huazhong University of Science and Technology
Obesity
Effects of Zinc Supplementation on Anthropometric Factors, Apelin and Inflammatory Markers in Obese Individuals
To study the effects of zinc supplement on anthropometric factors, Apelin and inflammatory markers in obese individuals, 50 obes person who referred to Diet and Nutrition clinic of Shahid Beheshti University of Medical Sciences…
- Trial name
- NCT02516475
- Testing
- zinc sulfate, corn starch
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Nutrition and Food Technology Institute
Obesity, Periodontitis
Periodontal Inflammation and Epigenetics in Obese Individuals
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis.
- Trial name
- NCT07610902
- Testing
- Non-surgical periodontal therapy will be administered
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Asthma, Asthma Chronic
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
- Conditions
- Asthma, Asthma Chronic, Overweight and Obesity
- Trial name
- NCT06273072
- Testing
- Metformin hydrochloride extended-release tablets
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Metabolically Unhealty Obese, Dyslipidemia
Effect of a Low-Calorie MCT-Rich Traditional Minangkabau Diet on Obese Individuals
This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity.
- Conditions
- Metabolically Unhealty Obese, Dyslipidemia, Diabetes (DM), Resistance, Insulin
- Trial name
- NCT07423884
- Testing
- Low-Calorie Diet Rich in Medium-Chain Triglycerides (MCTs) Based on Traditional Minangkabau Foods
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Andalas University
Inflammation, Inflammatory Response
A Study to Evaluate the Effects of a Marine Lipid Oil Concentrate Formulation on Inflammation
To assess the efficacy and safety of a Marine Lipid Oil Concentrate formulation on inflammatory biomarkers and overall well-being in male and female subjects who are overweight to mildly obese, but otherwise generally healthy.
- Trial name
- NCT04269876
- Testing
- Marine Lipid Oil Concentrate, Dietary Supplement
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Obesity, Anxiety Sensitivity
Computer-Delivered Intervention for Individuals With Obesity and Elevated Anxiety Sensitivity
The proposed study will design and evaluate a computerized-delivered single-session anxiety sensitivity reduction program (i.e., Anxiety Sensitivity Training; AST).
- Conditions
- Obesity, Anxiety Sensitivity, Eating, Physical Activity
- Trial name
- NCT03917901
- Testing
- Anxiety Sensitivity Training, Health Control
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Houston
Obesity
Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity
The goal of this clinical trial is to investigate whether a Ketogenic Diet (KD) can increase Total Energy Expenditure (TEE), while benefiting appetite, during weight loss maintenance in reduced-obese individuals.
- Trial name
- KETOWEI (NCT06736028)
- Testing
- Diet Therapy, Calorie Restriction, Behavioral Support
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Obesity, Methamphetamine Use Disorder
Tirzepatide for Obesity and Meth Use Disorder
This is an open-label pilot study to evaluate the feasibility and preliminary efficacy of using tirzepatide when prescribed for its United States (US) Food and Drug Administration (FDA)-approved weight-related indication in…
- Trial name
- NCT06745128
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Texas Southwestern Medical Center
Prediabetes, Obesity
Effects of Antidiabetic Medications on the Postprandial State in Prediabetes
This project addresses cardiovascular disease risk in patients with prediabetes. Levels of lipids after eating a meal ("postprandial lipids") are strong independent predictors of cardiovascular risk.
- Trial name
- NCT02104739
- Testing
- Exenatide, Saxagliptin, Exenatide extended-release (ER)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity & Overweight
Impact of Exercise-derived Extracellular Vesicle in Blood and Physical Fitness Data in Overweight/Obesity Individuals
This project aims to study the effect of exercise in the obesity/overweight on the changes of physical fitness and blood components.
- Trial name
- Exercise (NCT07312344)
- Testing
- High-intensity interval training exercise on treadmill
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Mahidol University
Overweight/Obesity (BMI: 27 and 35 kg/m2)
tVNS and Obesity-related Mechanisms
The overarching goal of the project is to assess whether transcutaneous Vagus Nerve Stimulation (tVNS) induced reduction of central and peripheral inflammation is associated with tVNS induced changes in mood and motivation in a…
- Trial name
- NCT06954844
- Testing
- Transcutaneous non-invasive vagus nerve stimulation (tVNS), Low intensity stimulation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Obesity, Morbid Obesity
Effects of RM-493 on Energy Expenditure in Obese Individuals
Background: RM-493 is a drug that stimulates parts of the brain that control eating and metabolism. It has helped to reduce body weight and improve insulin sensitivity in lab tests.
- Trial name
- NCT01867437
- Testing
- RM-493
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Obesity
Using a State-wide Initiative to Disseminate Effective Behavioral Weight Loss Strategies: Study 5
The purpose of this study is to examine whether providing additional intervention support to individuals with lower than expected weight loss within the initial stages of an internet-based behavioral weight loss program improves…
- Trial name
- NCT02163252
- Testing
- Standard, Early Intervention
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- The Miriam Hospital