Clinical trials: Obese Subjects
Dysglycemia, Obesity
Effects of Cinnamon Supplementation on Glucose Metabolism in Patients With Pre-diabetes
The transition from normal glucose tolerance to overt type 2 diabetes mellitus (T2D) encompasses a variety of glycemic abnormalities that are commonly referred to as 'prediabetes'.
- Trial name
- Cinnamon (NCT03219411)
- Testing
- Cinnamon
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Joslin Diabetes Center
Obesity
Effect of Coffee and Agave Inulin-based Beverage on Appetite in Adults With Obesity.
Nutritional treatment is key in managing obesity; however, the lack of fullness or satiety signals may affect adherence to this treatment.
- Trial name
- NCT06527209
- Testing
- Coffee and agave inulin-based beverage (A), Control beverage (B)
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Healthy, Liver Diseases
A Study to (1) Compare How BI 456906 is Taken up in the Body of Healthy People and People With Liver Problems and (2) Find Out How People With Overweight and Obesity, With and Without Liver Problems, Tolerate Different Doses of BI 456906
This study is open to adults who have different levels of liver problems and adults who are healthy. People with or without overweight or obesity can take part. This study has 2 parts.
- Conditions
- Healthy, Liver Diseases, Obesity
- Trial name
- NCT05296733
- Testing
- BI 456906
- Where
- 13 sites in United States, Germany and 4 more
- Volunteers
- 82 people
- Sponsor
- Boehringer Ingelheim
Metabolic Syndrome
Effects of Polyphenols of Pomegranate Fruit Peel Extract on Inflammation and Oxidative Stress in Metabolic Syndrome
The purpose of this study is to evaluate the effects of polyphenols of pomegranate fruit peel extract compared to placebo on oxidative stress and inflammation in overweight and obese subjects with metabolic syndrome.
- Trial name
- NCT05915117
- Testing
- Polyphenols of pomegranate fruit peel extract (PoPex)
- Where
- Bosnia and Herzegovina
- Volunteers
- 60 people
- Sponsor
- University of Banja Luka
Overweight and Obesity
Effect of the LEVAmethod by Bertz et al © in Subjects With Overweight or Obesity in Primary Health Care.
This study evaluates weight loss effect of the method LEVA by Bertz et al in subjects with overweight or obesity that are remitted to Primärvårdens Dietistenhet.
- Trial name
- LEVA-POP (NCT04184479)
- Testing
- LEVAmethod by Bertz et al
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Vastra Gotaland Region
Type2 Diabetes, Type 2 Diabetes Mellitus
Randomised Placebo-controlled Study of FMT to Impact Body Weight and Glycemic Control in Obese Subjects With T2DM
Faecal microbiota transplantation (FMT) represents a clinically feasible way to restore the gut microbial ecology, and has proven to be a breakthrough for the treatment of recurrent Clostridium difficile infection.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus, Obese
- Trial name
- NCT03127696
- Testing
- Fecal Microbiota Transplantation, Lifestyle Modification Program
- Where
- Hong Kong
- Volunteers
- 61 people
- Sponsor
- Chinese University of Hong Kong
Obesity
A Study to Determine the Effects of TM30339 on Weight Loss in Obese Individuals.
The purpose of this study is to determine the effects of TM30339 on weight loss in obese individuals after 28 days dosing.
- Trial name
- NCT00746824
- Volunteers
- 192 people
- Sponsor
- 7TM Pharma A/S
Obesity
Effect of Oral Feeding on Gastric Emptying, Gut Blood Flow, and Hormone Responses in Obese and Healthy Weight Subjects
Obesity is a complicated condition that is poorly understood. The aim of this study is to increase our knowledge of how the condition may arise, and what makes obese people remain obese.
- Trial name
- NCT03860623
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type 2 Diabetes, Overweight and Obesity
A Phase I Study of GZR18 Injection in Healthy Subjects
This trial is conducted in China. The aim of the trial is to evaluate the safety and tolerability of GZR18 injection in healthy subjects following single dose and once-weekly dose for 2 consecutive weeks until reaching the target…
- Trial name
- NCT06548997
- Testing
- GZR18
- Where
- China
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Obesity
A Phase III Study Comparing the Weight Loss Effects of Semaglutide Injection and Wegovy®
The purpose of the study is to compare the effect on body weight in subjects taking semaglutide injection or subjects taking Wegovy®.
- Trial name
- NCT06633783
- Testing
- Semaglutide
- Where
- 14 sites in China
- Volunteers
- 370 people
- Sponsor
- Hangzhou Jiuyuan Gene Engineering Co. Ltd.,
Obesity
The Predictive Capacity of Peripheral Muscle Function on Quality of Life Impairment at 1 Year in Subjects With Obesity
The assessment of health status and physical function is fundamental in patients with obesity, as they play an important role among the various factors influencing quality of life in this population.
- Trial name
- OBLITAM (NCT05479396)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hopital Forcilles
Metabolic Syndrome X
Evaluation of the Effects of a L.Reuteri Strain on Markers of Inflammation, Cardiovascular Risk and Fatty Liver Disease
The purpose of this study is the evaluation of the effects in obese patients with metabolic syndrome on the composition of the intestinal microbiota, markers of the syndrome (hypertension, dyslipidemia, inflammation biomarkers…
- Trial name
- PROSIR (NCT02972567)
- Testing
- Lactobacillus spp, Control
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Biosearch S.A.
Obesity, Overweight
A Study of SHR-2906 Injection in Healthy Subjects With a Single Dose and in Obese Patients With Multiple Doses
This study is a randomized, double-blind, placebo-controlled, dose-escalation phase I clinical trial. This study consists of two parts: the single-dose escalation study (SAD) in healthy subjects and the multiple-dose escalation…
- Trial name
- NCT07280936
- Testing
- SHR-2906 Injection
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Comparison of Glycemic Control in Obese Diabetics Using Three Different Pen Needles
Anxiety about needles is a concern commonly expressed by diabetics when beginning insulin therapy. A shorter, thinner pen needle that delivers insulin with the safety and efficacy profile of longer pen needles may appeal to many…
- Trial name
- NCT01231984
- Testing
- 4 mm x 32G Pen Needle, 8mm x 31G Pen Needle, 12.7mm x 29G Pen Needle
- Where
- 10 sites in United States
- Volunteers
- 293 people
- Sponsor
- Becton, Dickinson and Company
Obesity
Shifting and Distribution of Foot Pressure Among Obese Subjects
Background: The foot is considered a sensitive structure of musculoskeletal system that bears significant loads of the body weight during walking.
- Trial name
- NCT03441763
- Testing
- Emed foot device
- Where
- Saudi Arabia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Diabetes Mellitus, Type 2, Insulin Resistance
Evaluation of Intra-Abdominal Fat Extraction Using HydraSolve T2D™ in Obese Subjects With Type 2 Diabetes
This study will investigate the safety and efficacy of the investigational use of the HydraSolve T2D™ System in improving blood glucose control and insulin resistance in patients with obesity (Class 1, BMI 30-39.9 kg/m2) and type…
- Trial name
- NCT03953963
- Testing
- HydraSolve T2D™
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medality Medical
Obesity/Overweight
A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Obese/Overweight Subjects
This is a multicenter, randomized, double-blind, placebo-controlled phase III clinical study in adult obese/overweight subjects in China to evaluate the efficacy and safety of GZR18 Injection in the subjects.
- Trial name
- NCT06728124
- Testing
- GZR18
- Where
- China
- Volunteers
- 630 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Metabolic Syndrome, Obesity
Impact of the Metabolic Syndrome on the Incidence of Neuropathy in Obese Subjects
The primary purpose of this study is to discover modifiable risk factors for the development of neuropathy, specifically looking at the metabolic syndrome.
- Conditions
- Metabolic Syndrome, Obesity, Neuropathy
- Trial name
- NCT02689661
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Brian Callaghan
Healthy
Bioequivalence Study Comparing Naltrexone SR/Bupropion SR Trilayer Tablets From Two Manufacturers
This is a Phase 1, open-label, randomized, single-dose, 2-way crossover study in healthy adult subjects to assess the bioequivalence of naltrexone SR/bupropion SR combination trilayer tablets prepared at two different…
- Trial name
- NCT02259179
- Testing
- Reference naltrexone 8 mg SR/bupropion 90 mg SR combination trilayer tablets (2 tablets), Test naltrexone 8 mg SR/bupropion 90 mg SR combination trilayer tablets (2 tablets)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Orexigen Therapeutics, Inc
Overweight and Obesity
Developmental Endothelial Locus-1, Platelet Count, and Soluble P-selectin in Overweight and Obese Subjects
This observational study aims to detect serum levels of Developmental Endothelial Locus-1 (DEL-1), Platelet Count, and Soluble P-selectin (sP-sel) in Overweight and Obese Subjects.
- Trial name
- NCT05864079
- Testing
- Platelet count, Developmental endothelial locus-1 (DEL-1), soluble P-selectin (sP-sel)
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Aswan University Hospital