Clinical trials: Obese Subjects
Substance Dependence
Effects of the D3 Antagonist GSK598809 on Food Reward and Reinforcement
This novel compound is a new experimental treatment that may help people to stop compulsive overeating. Compulsive overeating or binge eating is one of the main reasons why people are overweight or obese.
- Trial name
- NCT01039454
- Testing
- GSK598809 Capsules
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity, Overweight
Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity
This study will look at the change in the participant's body weight from the start to the end of the study. This is to compare the effect on body weight in people taking semaglutide (a new medicine) and people taking "dummy"…
- Trial name
- STEP 2 (NCT03552757)
- Testing
- Semaglutide 1.0 mg, Semaglutide 2.4 mg
- Where
- 147 sites in United States, Argentina and 11 more
- Volunteers
- 1,210 people
- Sponsor
- Novo Nordisk A/S
Obesity
The Role of Atrial Natriuretic Peptide in the Lipolytic Process: Effect of Obesity and Exercise
In the developing countries, obesity prevalence is on a dramatic rise. Obesity is related to co-morbidities and as a result, obesity significantly shortens life expectancy and lowers quality of life.
- Trial name
- BALO (NCT02418728)
- Testing
- subcutaneous adipose tissue microdialysis under local beta/alpha blockade
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Obesity
A Preliminary Comparison of the Blood Levels of Medications in Obese Subjects Compared to Post-Gastric Bypass Subjects
The purpose of this study is to determine the difference, if any, in the area under the sertraline plasma level time curve (AUC) between patients who are nine to fifteen months post Roux-en-Y Bariatric Surgery and control…
- Trial name
- NCT01015976
- Testing
- bariatric surgery, control
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Neuropsychiatric Research Institute, Fargo, North Dakota
Obesity
Exploratory Study to Investigate the Effect of Dapagliflozin and Exenatide Combined on Body Weight
Obesity is a medical condition which increases the risk of other diseases, such as type 2 diabetes and cardiovascular disease. Obesity-related risk factors for the development of other metabolic diseases include unstable glucose…
- Trial name
- Dapalost (NCT02313220)
- Testing
- Dapagliflozin, Exenatide
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Obesity
A Study of Nasal PYY3-36 and Placebo for Weight Loss in Obese Subjects
The purpose of this study is to determine the effect of nasal PYY3-36 on weight loss post 24 weeks of treatment.
- Trial name
- NCT00537420
- Testing
- PYY3-36, Sibutramine
- Where
- 29 sites in United States
- Volunteers
- 551 people
- Sponsor
- Nastech Pharmaceutical Company, Inc.
Obesity
The Effect of Beverages Varying in Protein Quantity on Appetite and Energy Intake
Over the last decades, changes in the diet and lifestyle have led to overall energy imbalance becoming commonplace and the emergence of an obesity epidemic with more than 1.6 billion adults being overweight.
- Trial name
- NCT01849302
- Testing
- Beverages varying in macronutrient content on appetite
- Where
- Sweden
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Lund University
Solid Tumor, Obesity
Study of Single and Multiple Oral Doses of SCB0020160 in Healthy Adult Male Subjects
This study aims to evaluate the safety, tolerability, pharmacokinetics, and food effect of a new investigational medicine called SCB0020160 in healthy adult men. This is the first time SCB0020160 will be administered to humans.
- Conditions
- Solid Tumor, Obesity, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT07682337
- Testing
- SCB0020160
- Where
- Australia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- SCBIO Inc.
Obesity
Effects of a Probiotic on Body Weight
Probiotics administration is associated with health benefits on gut barrier integrity and immunological functions of the gastrointestinal tract.
- Trial name
- NCT01106924
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Laval University
Obesity, Overweight
Effect of Yoghurts Enriched With XXS (Mixture of Natural Polyphenolic Compounds and Plant Extracts) on the Evolution of Weight in Overweight Subjects
Overweight and obesity are public health problems worldwide. Even though heredity may be one of the causes the diseases, the vast majority of cases is rather linked to a sedentary lifestyle associated or not with a low-variety…
- Trial name
- VITALIM Senior (NCT02810041)
- Testing
- yoghurts enriched with XXS, yoghurts non enriched with XXS
- Where
- France
- Volunteers
- 93 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Obesity
The Effect of SHR20004（Noiiglutide ） on Body Weight in Obese Subjects Without Diabetes
The study is being conducted to assess the efficacy and safety of SHR20004 on body weight in obese subjects without diabetes.
- Trial name
- NCT04799327
- Testing
- SHR20004
- Where
- 2 sites in China
- Volunteers
- 254 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Obesity
Weight Loss In Obese Subjects Taking Either GW869682 Or Placebo 3 Times Per Day For 12 Weeks
GW869682 causes glucose to be excreted in the urine. The purpose of this study is to see whether enough calories from glucose are excreted in the urine to cause weight loss.
- Trial name
- NCT00297180
- Testing
- GW869682
- Where
- 3 sites in United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity
A Clinical Study Comparing Semaglutide Injection and Wegovy® for Weight Management in Obese Subjects
This is a multicenter, randomized, open, parallel, positive-controlled clinical study to evaluate the efficacy and safety of Semaglutide injection (TQF3510) developed by Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Trial name
- NCT06738979
- Testing
- TQF3510 (Semaglutide Injection), Wegovy®
- Where
- 66 sites in China
- Volunteers
- 408 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Obesity, Overweight
A Research Study of How NNC0174-0833 Behaves in Japanese and Caucasian Volunteers Who Are Normal Weight, Overweight or With Obesity
The aim of this study is to look at how the study medicine behaves in the participant's body and how it is removed from the participant's body.
- Trial name
- NCT03787225
- Testing
- NNC0174-0833
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Novo Nordisk A/S
Endothelial Dysfunction, Hypertension
FFA-Induced Hypertension and Endothelial Dysfunction
The study is a prospective open label study to examine the effects of oral and intravenous fat load on blood pressure, endothelial function, sympathetic activity, and oxidative stress in obese healthy subjects.
- Trial name
- NCT00589888
- Testing
- Intralipid 20% @ 20cc/hour, Intralipid 20%@ 40cc/hour, Normal Saline
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Emory University
Overweight and Obesity
A Research Study of How NNC0174-0833 Behaves in Chinese Volunteers Who Are Normal Weight, Overweight or With Obesity
The aim of this study is to look at how the study medicine behaves in participants body and how it is removed from their body. The study compares three different doses of the study medicine in Chinese healthy men.
- Trial name
- NCT05254158
- Testing
- NNC0174 0833
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
Diet With or Without Metarecod® in Obese Subjects With Type 2 Diabetes
Obesity is considered the largest chronic non-communicable disease (globesity) worldwide with a growing trend in the near future.
- Trial name
- MONDO (NCT06813170)
- Testing
- Metarecod, Diet
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Overweight, Obesity
VDR Gene Polymorphisms and Weight Loss in Non-diabetic Overweight and Obese Subjects
This is a six months intervention study in non-diabetic overweight and obese subjects. Subjects will be counseled for weight loss through diet and exercise.
- Trial name
- NCT03386331
- Testing
- diet and exercise
- Where
- India
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Overweight, Obesity
The Additive Effect of Cognitive Behavioral Treatment (CBT) to Conventional Weight Loss Intervention Program for Young Adults With Intellectual Disabilities
In this randomized case control study we will evaluate the additive effect of psychological intervention, i.e CBT-cognitive behavioral treatment in a multi-strategy weight loss program composed of physical activity intervention…
- Conditions
- Overweight, Obesity, Learning Disability
- Trial name
- NCT01032369
- Testing
- Nutritional intervention and physical activity, Nutritional intervention, physical activity and behavioral treatment
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Overweight, Obesity
Effect of GSP3 on Body Weight in Overweight and Obese Subjects
The FLOW (First Loss Of Weight) study is designed to assess the effects of repeated administration of GSP3, an investigational product, on body weight.
- Trial name
- FLOW (NCT03008954)
- Testing
- GSP3, Avicel (modified Cellulose)
- Where
- 5 sites in Czechia, Denmark and 1 more
- Volunteers
- 128 people
- Sponsor
- Gelesis, Inc.