Clinical trials: Obese Subjects
Type 2 Diabetes Mellitus
A Study of TG103 Injection in Overweight/Obese Subjects With Type 2 Diabetes
The main purpose of this study is to evaluate the efficacy, safety, PK and PD characteristics of different doses of TG103 injection in overweight/obese subjects with type 2 diabetes mellitus.
- Trial name
- NCT05063253
- Testing
- TG103
- Volunteers
- 208 people
- Sponsor
- CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.
Obesity
Exploratory Study to Investigate the Effect of Dapagliflozin and Exenatide Combined on Body Weight
Obesity is a medical condition which increases the risk of other diseases, such as type 2 diabetes and cardiovascular disease. Obesity-related risk factors for the development of other metabolic diseases include unstable glucose…
- Trial name
- Dapalost (NCT02313220)
- Testing
- Dapagliflozin, Exenatide
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Obesity
A Study to Determine the Effects of TM30339 on Weight Loss in Obese Individuals.
The purpose of this study is to determine the effects of TM30339 on weight loss in obese individuals after 28 days dosing.
- Trial name
- NCT00746824
- Volunteers
- 192 people
- Sponsor
- 7TM Pharma A/S
Childhood Obesity, Adolescent Obesity
Effects of COcoa Supplement in OBese Adolescent Subjects
Childhood obesity is a serious public health problem internationally. In addition to being associated with the early onset of chronic degenerative diseases such as diabetes, dyslipidemias, coronary artery diseases, among others.
- Trial name
- COOBA (NCT04112251)
- Testing
- Cocoa Flavonols Supplement
- Where
- Mexico
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- National Polytechnic Institute, Mexico
Metabolic Syndrome
The Effect of Metamin 3D on the Lipid and Glucose in Subjects With Metabolic Syndrome
To evaluate the effect of Metamin 3D on improvement of glucose and lipid on Taiwanese subjects with metabolic syndrome.
- Trial name
- NCT01120873
- Testing
- Metamin 3D
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Taichung Veterans General Hospital
Metabolic Syndrome, Overweight
Trial of Two Dietary Programs on Cardiometabolic Risk Factors in Subjects With Metabolic Syndrome
The objective of this study was to investigate from 3 sites (University of Connecticut, University of Florida, and University of California, Irvine) whether enhancement of a modified Mediterranean-style, low glycemic load diet…
- Conditions
- Metabolic Syndrome, Overweight, Obesity, Hypercholesterolemia
- Trial name
- HMS4 (NCT01010841)
- Testing
- UltraMealPlus 360 (Medical food), Low-glycemic-load diet
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- MetaProteomics LLC
Obesity, Type 2 Diabetes
Characterization of Metabolic Biomarkers in Varying Subjects
Traditional dietary, lifestyle, behavioral and pharmacologic treatment strategies have proven relatively ineffective for treating obesity, and once metabolic abnormalities such as Type 2 Diabetes (T2D) develop, definitive…
- Trial name
- NCT01199692
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- CPL Associates
Obesity, Overweight
A Safety and Efficacy Study of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects Participating in an Intensive Behavior Modification Program
The purpose of this study is to determine whether a combination of naltrexone SR and bupropion SR is safe and effective in treating obesity and leads to greater weight loss when given with a group lifestyle modification program…
- Trial name
- NCT00456521
- Testing
- Naltrexone SR 32 mg/ bupropion SR 360 mg/ day, Intensive group lifestyle modification counseling
- Where
- 9 sites in United States
- Volunteers
- 793 people
- Sponsor
- Orexigen Therapeutics, Inc
Healthy Human Male Subjects
The Influence of Liraglutide on the Reward Properties of Food: an fMRI Study on Healthy Volunteers
Clinical experience has confirmed the anorexic effect of Glucagon-like-peptide 1 (GLP-1) mimetics in comparison to DPP-4 inhibitors.
- Trial name
- NCT01695109
- Testing
- Liraglutide
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Overweight, Obesity
Safety and Efficacy of Litramine in Overweight and Obese Subjects
Preparations that bind to nutritional fat and inhibit its absorption could be decisively meaningful for the regulation of bodyweight or obesity.
- Conditions
- Overweight, Obesity, Weight Loss
- Trial name
- NCT01233349
- Testing
- Litramine
- Where
- Germany
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Obesity
A First-Time-in-Human Study to Assess the Safety and Tolerability of PP 1420 in Healthy Subjects
When humans eat, the bowels naturally secrete chemicals into the bloodstream which make people feel full and which stop eating. One of these chemicals is known as "Pancreatic Polypeptide" (PP).
- Trial name
- NCT01052493
- Testing
- PP 1420
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity
First in Human Study in Subjects With Obesity, But Otherwise Healthy
This is a First in Human study to evaluate the safety and tolerability of DA-1726 following single and multiple doses in participants with obesity, but otherwise healthy subjects.
- Trial name
- NCT06252220
- Testing
- DA-1726
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Overweight and Obesity
Extension Study of Gelesis100 on Body Weight
This study is designed to assess the effect of Gelesis100 on body weight after an additional exposure of 24 weeks in subjects who completed the 24-week treatment period, and had at least 3% weight loss, in the Gelesis Loss Of…
- Trial name
- GLOW-EX (NCT03021291)
- Testing
- Gelesis100 (2.25 g)
- Where
- 16 sites in United States, Czechia and 3 more
- Volunteers
- 36 people
- Sponsor
- Gelesis, Inc.
Epicardial Fat
Semaglutide vs Dulaglutide on Epicardial Adipose Tissue
Epicardial Fat (EAT), the visceral fat depot of the heart, is a modifiable cardio-metabolic risk factor and therapeutic target. EAT expresses GLP-1 receptors (GLP-1R).
- Trial name
- NCT04200625
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Miami
Nocturnal Hypoventilation, Obesity
Prevalence of Nocturnal Hypoventilation in Obese Subjects Fiited With Continuous Positive Airway Pressure for Obstructive Sleep Apnea / Hypopnea Syndrome
CAPNOSOH study is a single-center study conducted at Toulouse University Hospital, aiming to estimate the prevalence of obese and apneic subjects maintaining nocturnal hypoventilation under continuous positive airway pressure…
- Conditions
- Nocturnal Hypoventilation, Obesity, Sleep Apnea Hypopnea Syndrome
- Trial name
- CAPNOSOH (NCT07152990)
- Testing
- Transcutaneous Oxy-Capnography, Quality of life questionnaires, Arterial gasometry
- Where
- France
- Volunteers
- 139 people
- Sponsor
- University Hospital, Toulouse
Periodontal Diseases, Obesity
Evaluation of Periodontal Diseases and Obesity in Women
The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin…
- Trial name
- NCT03442920
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Obstructive Sleep Apnoea, Obesity
Obstructive Sleep Apnoea and Adipose Tissue Dysfunction
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea.
- Conditions
- Obstructive Sleep Apnoea, Obesity, Hypoxia
- Trial name
- NCT02518633
- Testing
- Continuous positive airway pressure devices
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Obesity
Grape Polyphenols and Second-meal Effect
The aim of this is study is to evaluate the effects of a single intake of grapes (a polyphenol-rich food) in postprandial metabolism in subjects with obesity, including a first intake (high-fat breakfast) after overnight fasting…
- Trial name
- GRAPESECOND (NCT03741218)
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Type 2 Diabetes
Metabolic Effects of Gastrointestinal Surgery in T2DM
Gastric bypass surgery resolves type 2 diabetes mellitus (T2DM) without the need for diabetes therapy in ~80% of patients. Moreover, improvement in insulin sensitivity and glucose homeostasis occurs within days after surgery…
- Trial name
- NCT01771185
- Testing
- Duodenal jejunal bypass plus sleeve gastrectomy, Best medical treatment (Metformin ; gliclazide)
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Obesity
A Study Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Naltrexone SR/ Bupropion SR Therapy in Overweight or Obese Subjects
The purpose of this study was to assess the effect of naltrexone SR/bupropion SR (NB) on brain function in response to food cues using functional magnetic resonance imaging in overweight or obese subjects.
- Trial name
- NCT00711477
- Testing
- Naltrexone SR 32 mg/bupropion SR 360 mg/day, fMRI scan
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Orexigen Therapeutics, Inc