Clinical trials: Obese Subjects
Obesity, Morbid Obesity
Safety Evaluation of the LGL102 in Obese Subjects Treated With OMS102
The main objective of this study is to evaluate the LGL102 implant safety in obese to morbidly obese subjects treated with OMS102 system. The effect of the therapy on body weight changes will be also evaluated.
- Trial name
- NCT01539850
- Testing
- OMS102
- Where
- 3 sites in Germany
- Volunteers
- 34 people
- Sponsor
- IntraPace, Inc
Obesity
A Study to Characterise the Physiology of Weight Loss and Regain Under Dietary, Behavioural and Pharmacological Interventions in Healthy Obese Subjects
Approximately 60 obese, but otherwise healthy, subjects will be assessed in this benchmark study to investigate the physiological changes associated with weight loss and regain.
- Trial name
- NCT01597609
- Testing
- sibutramine
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity
Abnormal Eating and Taste Perception in Subjects With Obesity
The identification of safe and effective strategies for weight loss and long-term maintenance is critical to reduce the alarming prevalence of obesity worldwide and mitigate obesity-associated health risks.
- Trial name
- TASTEOB (NCT05772052)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Auxologico Italiano
Obesity
Research Study Looking at How Well Semaglutide Works in People Living With Obesity and Prediabetes
This study looks at how well a new medicine, called semaglutide, works at helping people with obesity and prediabetes. This study will look at how much weight participants lose, and if participants can go from having blood sugar…
- Trial name
- STEP 10 (NCT05040971)
- Testing
- Semaglutide 2.4 mg
- Where
- 43 sites in Canada, Denmark and 3 more
- Volunteers
- 207 people
- Sponsor
- Novo Nordisk A/S
Obesity
Sodium Tungstate in Obesity
The purpose of this study is to compare the efficacy and safety of sodium tungstate versus placebo in patients with obesity (grade I and II).
- Trial name
- TROTA-1 (NCT00555074)
- Testing
- Sodium Tungstate
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Clinic of Barcelona
Obesity
Protein Dose-repsonse Effect on GLP-1, PYY and Appetite in Male Subjects
Dietary protein appears to be the most satiating and thermogenic macronutrient. However, how protein exerts its effect on appetite is not fully known.
- Trial name
- Protein (NCT01561235)
- Testing
- Dose-reponse effect of protein on appetite and appetite-regulating hormones
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Subcutaneous Fat Disorder
Safety and Efficacy Study of 10XB-101 in Adults With Bilateral Flank Adiposity
The goal of this clinical trial is to test the safety and effectiveness of an injection study drug in decreasing bilateral flank adiposity.
- Trial name
- NCT05760248
- Testing
- 10XB-101 Solution for Injection, 6.0%
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- 10xBio, LLC
Obese Subjects Who Will Undergo Gastric By-pass Surgery
Effect of Bariatric Surgery on Kidney Function
Primary hypothesis: A large reduction in weight is not associated with a change in accurately measured glomerular filtration rate (GFR) (51Chromium ethylenediaminetetraacetic acid plasma clearance (51Cr-EDTA)).
- Trial name
- GAS (NCT02138565)
- Testing
- Gastric by-pass surgery
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Steno Diabetes Center Copenhagen
Hypothalamic Injury-induced Obesity (HIO)
48 Weeks, Study to Evaluate Overall Safety and Tolerability of Co-administration of Tesofensine and Metoprolol in Subjects With Hypothalamic Injury-induced Obesity (HIO)
Double-blind, randomized, placebo-controlled, single- center study followed by an open-label extension period. The study will have two parts: Part 1: 24 weeks double-blind treatment (DB), followed by Part 2: 24 weeks open-label…
- Trial name
- NCT03845075
- Testing
- Tesofensine/Metoprolol
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Saniona
Obesity
Anti-psychotic Medication (Stable Dose) Weight Loss Study
This is a pilot study to determine the safety and efficacy of an investigational product (IHBG-10) on weight change and changes in body composition in subjects who have been taking a stable dose of certain anti-psychotic…
- Trial name
- NCT01272765
- Testing
- IHBG-10
- Where
- United States
- Sponsor
- Avera McKennan Hospital & University Health Center
Obstructive Sleep Apnea (OSA) and Obesity
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of HDM1005 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity Receiving Positive Airway Pressure (PAP) Therapy
This is a 56-week randomized, double blinded, parallel-controlled study evaluating the efficacy and safety of the HDM1005 in patients with obstructive sleep apnea (OSA) and obesity receiving positive airway pressure (PAP)…
- Trial name
- NCT07794397
- Testing
- HDM1005
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Metabolism and Nutrition Disorder, Obesity
Research Study of a New Medicine (NNC9204-1706) in People With Overweight or Obesity
The study is testing a new medicine for weight control in people with overweight or obesity. The aim of the study is to find out how safe the study medicine is and how it works in the body.
- Trial name
- NCT03661879
- Testing
- NNC9204-1706
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Adverse Drug Event, Side Effects of Drugs
Safety and Tolerability of Krill Powder Supplement in Slightly Overweight People With Moderately Elevated Blood Pressure
The aim of this study was to systematically collect data on safety and tolerability of krill powder in humans and simultaneously gain efficacy data by measuring the risk factors for cardiovascular disease.
- Trial name
- NCT03112083
- Testing
- Nutritional counseling A, Nutritional counselling B
- Where
- Finland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Olympic Seafood AS
Obesity
Safety, Toleration and Efficacy of CP-741,952 for the Treatment of Obesity
The purpose of this study is to determine whether CP-741,952 is effective in the treatment of obesity and to determine 12 week safety and toleration.
- Trial name
- NCT00367783
- Testing
- CP-741,952
- Where
- 5 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pfizer
Obesity
A Phase III Study Comparing the Weight Loss Effects of Semaglutide Injection and Wegovy®
The purpose of the study is to compare the effect on body weight in subjects taking semaglutide injection or subjects taking Wegovy®.
- Trial name
- NCT06633783
- Testing
- Semaglutide
- Where
- 14 sites in China
- Volunteers
- 370 people
- Sponsor
- Hangzhou Jiuyuan Gene Engineering Co. Ltd.,
Obesity
Polyglucosamine L112 in Overweight and Obese Subjects
This research proposes as its main purpose to evaluate the effectiveness of the intake of Polyglucosamine at a dose of 3 g / day on weight loss in a group of subjects suffering from overweight and mild obesity (BMI between 25 and…
- Trial name
- NCT05022732
- Testing
- Polyglucosamine L112
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Diabetes Mellitus, Type 2, Overweight and Obesity
Effect of a Low-calorie and High-protein Diet Specially Rich in Animal Protein Compared to a Low-calorie and High-protein Diet Specially Rich in Plant Protein on Glucose Metabolism in Subjects With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
The aim of the study is to explore the effect of a low-calorie diet rich in protein (with a content of 35% of the total calories of the diet), mostly coming from animal sources (75% of total protein), compared to a hypocaloric…
- Conditions
- Diabetes Mellitus, Type 2, Overweight and Obesity, PreDiabetes
- Trial name
- NCT05456347
- Testing
- Low-calorie and high-protein diet with the majority of protein coming from animal sources., Low-calorie and high-protein diet with the majority of protein coming from plant sources.
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad de Zaragoza
Uric Acid Stones
Toxicity of Perirenal Fat in Overweight or Obese Subjects: A Pathophysiological Link Between Uric Acid Stones and Renal Ammonium Formation
Patients who are overweight or obese, diabetic or not, share with those who are suffering from uric stones the same way to remove abnormal acidity of the body in urine, ie a kidney ammoniogenesis default.
- Trial name
- NCT02561858
- Testing
- acid load test
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sleep Apnea, Gastroesophageal Reflux Disease
Effect of Continuous Positive Airway Pressure (CPAP) on Lower Esophageal Sphincter Pressure in Morbidly Obese Patients
This trial is enrolling patients who are already being seen at OHSU weight loss clinic or have been referred for clinical reasons by their physician to the OHSU weight loss clinic and are going to have a esophageal manometry that…
- Trial name
- NCT01099735
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Overweight, Obesity
Efficacy and Safety of Glucosanol in Maintaining Body Weight
To date, there is no clinical evidence on the efficacy and safety of Glucosanol in maintaining weight loss beyond the study duration of 12 weeks.
- Trial name
- NCT01435278
- Testing
- Glucosanol
- Where
- Germany
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- InQpharm Group