Clinical trials: Obese Subjects
Obesity
A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics in Adult Participants With Obesity
This study is to assess adverse events, change in body weight and pharmacokinetics in adult participants with obesity receiving ABBV-295 subcutaneous injections or matching placebo.
- Trial name
- NCT07291232
- Testing
- ABBV-295
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- AbbVie
Type 2 Diabetes
Exeantide in Type 2 Diabetes on Insulin
Exenatide has been shown to result in better glycemic control in type II diabetes patients. Obesity and diabetes are states of increased inflammation; exenatide is expected to lead to decreased inflammation by virtue of better…
- Trial name
- NCT01154933
- Testing
- exenatide 5 mcg, exenatide 10 mcg
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University at Buffalo
Overweight
A Single Dose Study Of PF-04620110 In Overweight And Obese, Otherwise Healthy Volunteers
PF-04620110 is a novel compound proposed for the treatment of Type 2 diabetes mellitus. The purpose of this study is to characterize the safety, tolerability, pharmacokinetics and pharmacodynamics following a single oral dose.
- Trial name
- NCT00799006
- Testing
- PF-04620110
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Pfizer
Metabolic Syndrome, Obesity
Glypican4 and CTRP5 in Metabolic Syndrome and the Effect of Exercise on These Adipokines
Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines.
- Trial name
- NCT01688622
- Testing
- 3months Exercise
- Where
- South Korea
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Korea University
Obesity
A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With Obesity
This study is a multicenter, randomized, open-label, parallel-controlled, phase III study to compare the efficacy, safety, and tolerability of HRS9531 versus semaglutide once weekly (QW) in adult subjects with obesity
- Trial name
- NCT07285902
- Testing
- HRS9531 injection, Semaglutide Injection
- Where
- 2 sites in China
- Volunteers
- 572 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Obesity
Effect of Body Composition on Thyroid Hormone Levels Among Overweight and Obese Subjects
The study was aimed at investigating the relationship between body composition and thyroid hormone levels in overweight and obese subjects (BMI≥25 Kg/m2)
- Trial name
- 3/2020 (NCT04327375)
- Testing
- Observational
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Healthy
Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin (JNJ-28431754) in Otherwise Healthy Obese Volunteers
The purpose of this study is to assess the pharmacokinetics (ie, how the body affects the drug) and pharmacodynamics (ie, how the drug affects the body) of increasing doses of canagliflozin (JNJ-28431754) in healthy obese…
- Trial name
- NCT01756404
- Testing
- Canagliflozin (JNJ-28431754)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy, Non-diabetic Overweight or Obese
A Study of BGM0504 Tablets in Healthy and Non-diabetic Overweight or Obese Chinese Subjects
A Randomized, Double-Blind, Placebo-Controlled, Single/Multiple-dose Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of BGM0504 Tablets Orally Administered in Healthy and Non-diabetic Overweight or Obese…
- Trial name
- NCT07239973
- Testing
- BGM0504 tablets
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- BrightGene Bio-Medical Technology Co., Ltd.
Bariatric Surgery Candidate
Pharmacokinetics and Pharmacodynamics of Edoxaban Before and After Bariatric Surgery
The study will be conducted at a single site in the Canada, Quebec. Participants will be recruited from the bariatric surgery clinic and will be required to be either, waiting for sleeve gastrectomy surgery (n=12, restrictive…
- Trial name
- EXPOSE (NCT06326138)
- Testing
- Edoxaban Pharmacokinetics and Pharmacodynamics
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Type 2 Diabetes Mellitus
Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Participants With Type 2 Diabetes
A Phase 2 study Comparing the effects on glucose control of MEDI0382 in combination with Dapagliflozin and Metformin compared to placebo in combination with Dapagliflozin and Metformin in overweight/obese participants with Type 2…
- Trial name
- NCT03444584
- Testing
- MEDI0382, Dapaglifozin, Metformin
- Where
- 8 sites in Germany, Hungary and 1 more
- Volunteers
- 49 people
- Sponsor
- MedImmune LLC
Obesity
Home-based Training in Obese Individuals
Generally, the enhancement of physical fitness depends on the optimal modulation of different physiological, technical or psychological stimuli and within the factors the would contribute to a decrease performance level, obesity…
- Trial name
- FITOB (NCT05773690)
- Testing
- Movement quality, Conventional Resistance Training
- Where
- Italy
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Hyperlipidemias, Triglycerides High
Effects of MCDG Oil on Postprandial Lipid Metabolism
It is well known that medium chain triglycerides (MCTs) and diacylglycerols (DGs) have effects on lowering circulating triglycerides (TGs).
- Trial name
- NCT03415568
- Testing
- LCT oil, MCDG oil
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Insulin Resistance
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (PEG)-BHD1028
Adiponectin has been known to play critical roles in various physio-regulatory processes, and adiponectin deficiency may contribute to insulin resistance. (PEG)-BHD1028 was developed as an agonist of adiponectin receptors.
- Trial name
- NCT06563115
- Testing
- (PEG)-BHD1028 Single Ascending Dose, (PEG)-BHD1028 Multiple Ascending Dose
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- EncuraGen, Inc
Health Adult Subjects, Obesity & Overweight
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Orally Administered TIX100 in Healthy Subjects
Randomized, Placebo-controlled Study to determine the safety and tolerability of multiple oral doses of TIX100 administered daily for 28 days to otherwise healthy overweight/obese subjects.
- Trial name
- NCT07675590
- Testing
- TIX100
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- TIXiMED, Inc.
Type 2 Diabetes Mellitus
A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK-5823 in Overweight or Obese Participants Who Are Healthy or Have Type 2 Diabetes Mellitus (MK-5823-002)
The purpose of this study is to assess the multiple rising dose safety/tolerability and pharmacokinetics of MK-5823 in overweight/obese participants who are healthy and overweight/obese participants with Type 2 diabetes mellitus…
- Trial name
- NCT01614782
- Testing
- MK-5823
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes
Safety and Tolerability Study of Cotadutide in Japanese Obese Subjects With Type 2 Diabetes Melitus
This is a Phase 1 study designed to assess the safety and tolerability of MEDI0382 (Cotadutide) in Japanese T2DM patients.
- Trial name
- NCT04208620
- Testing
- Cotadutide
- Where
- 3 sites in Japan
- Volunteers
- 16 people
- Sponsor
- AstraZeneca
Appetite
Metabolic Responses After 12-week Hypocaloric Diet Supplemented With a Cereal-based Plant Protein Biscuit
Biscuits enjoy high popularity in the human diet and can be excellent snack alternatives and potential carriers of ingredients with appetite regulating properties.
- Trial name
- NCT05213559
- Testing
- wheat biscuit enriched with plant proteins, common wheat biscuit
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Overweight and Obesity
Developmental Endothelial Locus-1, Platelet Count, and Soluble P-selectin in Overweight and Obese Subjects
This observational study aims to detect serum levels of Developmental Endothelial Locus-1 (DEL-1), Platelet Count, and Soluble P-selectin (sP-sel) in Overweight and Obese Subjects.
- Trial name
- NCT05864079
- Testing
- Platelet count, Developmental endothelial locus-1 (DEL-1), soluble P-selectin (sP-sel)
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Aswan University Hospital
Obesity
Diet and COVID-19 Vaccination
Recently, obesity and excess visceral fat were shown to be major risk factors for the development of complications following Covid 19 infection.
- Trial name
- NCT05163743
- Testing
- Low Calorie Ketogenic Diet
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Abdominal Obesity Metabolic Syndrome
Effect of Pyridoxamine Supplementation on Vascular Function and Insulin Sensitivity
A growing body of evidence demonstrates that increased adipose mass, especially visceral adipose tissue, contributes directly towards an increase in systemic inflammation, (micro-)vascular dysfunction and the burden of…
- Trial name
- NCT02954588
- Testing
- Pyridoxamine
- Where
- Netherlands
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center