Clinical trials: Obese Subjects
Cardiovascular Disease, Diabetes Type 2
Postprandial Inflammation and Fatty Acids
The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on peripheral blood mononuclear cells (PBMC) whole genome expression of obese and type 2…
- Conditions
- Cardiovascular Disease, Diabetes Type 2, Obesity
- Trial name
- PIFA (NCT00977262)
- Testing
- High saturated fat shake, High monounsaturated fat shake, High polyunsaturated fat shake
- Where
- 2 sites in Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Overweight, Obesity
Research Study to Investigate How Well Semaglutide Works Compared to Liraglutide in People Living With Overweight or Obesity
This study will look at participants' body weight from the start to the end of the study. The study will last for about 1½ years.
- Trial name
- STEP 8 (NCT04074161)
- Testing
- Semaglutide, Liraglutide
- Where
- 19 sites in United States
- Volunteers
- 338 people
- Sponsor
- Novo Nordisk A/S
Obesity
Effects of Fenofibrate on the Safety, Toleration and Efficacy Biomarkers of CP-742,033
The purpose of this study is to determine whether fenofibrate effects the toleration, safety, or efficacy biomarkers of CP-742,033, a drug being developed for the treatment of obesity.
- Trial name
- NCT00376285
- Testing
- CP-742,033, Fenofibrate
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Metabolism and Nutrition Disorder, Obesity
A Trial Investigating Safety, Tolerability, PK and PD for Multiple Doses of NNC9204-0530 in Male and Female Subjects Being Overweight or With Obesity
This trial is conducted in the United States of America. The aim of the trial is to investigate Safety, Tolerability, PK and PD for Multiple Doses of NNC9204-0530 in Male and Female Subjects being overweight or with obesity
- Trial name
- NCT02835235
- Testing
- NNC9204-0530
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Novo Nordisk A/S
Comorbidities, Confinement
Evaluation of Changes in Weight, Sleep, and Other Psycho-behavioural Parameters During Covid-19 Confinement in Subjects Monitored by the RNPC Network
During confinement, food intake can become compulsive, physical activity is significantly reduced, sleep is altered with exacerbated anxiety and stress levels and increased family violence.
- Conditions
- Comorbidities, Confinement, Obesity
- Trial name
- CO-RNPC (NCT04409197)
- Where
- France
- Volunteers
- 4,789 people
- Sponsor
- University Hospital, Grenoble
Non-Alcoholic Steatohepatitis
Safety and Tolerability Study of SHP626 in Overweight and Obese Adults
This study will investigate the safety and tolerability of daily dosing regimens of SHP626 in overweight and obese adults.
- Trial name
- NCT02287779
- Testing
- SHP626
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mirum Pharmaceuticals, Inc.
Morbid Obesity, Respiratory Failure
Comparison of Esophageal Manometry and CT Scan Measurements
The goal of this study is to determine the relationship between esophageal pressure (Pes) and superimposed pressure (SP) in subjects with morbid obesity.
- Trial name
- NCT04213911
- Testing
- low-dose chest CT scan, insertion of esophageal balloon
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Diabetes, Obesity
Brain Blood Flow and Lactate in Non-obese and Obese Subjects
Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity.
- Trial name
- NCT06791837
- Testing
- EXERCISE
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Metabolic Syndrome
Effect of Metabolaid® on AMPK Activation for Weight Loss
The objective of this study was to establish a formulation, containing both Hibiscus sabdariffa L. (HS) and Lippia citriodora L.
- Trial name
- NCT03568877
- Testing
- Metabolaid®
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Circadian Rhythm, Diabetes
Study of Circadian Clock Properties in Healthy Subjects, Obese and Type 2 Diabetic Patients.
The investigators aimed to characterize human circadian clockwork in healthy individuals in comparison to obese and type 2 diabetic subjects, employing the noninvasive experimental approach allowing the study of circadian profile…
- Conditions
- Circadian Rhythm, Diabetes, Obesity
- Trial name
- NCT02384148
- Testing
- Circadian rhythm measurement, Skin biopsy
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Hypothalamic Obesity, Prader-Willi Syndrome
A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
The purpose of this study is to evaluate the safety, tolerability, and PK of RM-718 in healthy subjects with obesity and in patients with MC4R Pathway Impairment
- Conditions
- Hypothalamic Obesity, Prader-Willi Syndrome, PWS
- Trial name
- NCT06239116
- Testing
- Part C: RM-718, Part D: RM-718
- Where
- 7 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Obesity, Weight Loss
Changes in Gut Hormones, Body Composition and Energy Expenditure After Roux-en-Y
The purpose of this study is to gain a better understanding of the mechanism of weight regain through gut hormone (substances in the gut that control various functions of the digestive organs) and energy expenditure (the amount…
- Trial name
- NCT02048501
- Testing
- Resting Metabolic Rate (RMR), Duel-energy x-ray absorptiometry (DEXA), Visual Analog Scale (VAS)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Evaluation of the Effect of Pramlintide on Satiety and Food Intake
This is a single center, randomized, blinded, placebo-controlled, two-period, cross-over study to evaluate the effect of pramlintide on satiety and food intake in normal-weight and obese non-diabetic subjects and in…
- Trial name
- NCT00042601
- Testing
- Pramlintide acetate
- Where
- Australia
- Volunteers
- 51 people
- Sponsor
- AstraZeneca
Healthy
Open-Label Pharmacokinetic of Oseltamivir in Healthy Obese Thai Adult Subjects
This study is planned to characterize the pharmacokinetic properties of oseltamivir and the active product--oseltamivir carboxylate--in obesity in order to provide clinical guidance for the optimum oseltamivir treatment regimens…
- Trial name
- NCT01049763
- Testing
- oseltamivir
- Where
- Thailand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- South East Asia Infectious Disease Clinical Research Network
Overweight , Obesity
A Study of Zovaglutide in Subjects With Overweight or Obesity (HORIZON-1)
This study will evaluate the percentage change in body weight from baseline and proportion of subjects achieving ≥ 5% weight loss from baseline after 52 weeks of treatment with Zovaglutide in subjects with overweight/obesity.
- Trial name
- NCT07230119
- Testing
- Zovaglutide dose 1, Zovaglutide dose 2
- Where
- 45 sites in China
- Volunteers
- 755 people
- Sponsor
- Beijing QL Biopharmaceutical Co.,Ltd
Overweight, Obesity
A Study to Evaluate AMG 133 Administered Subcutaneously in Participants With Overweight or Obesity
The primary objective of this study is to assess the pharmacokinetics (PK) of AMG 133 after multiple subcutaneous (SC) administrations in participants with overweight or obesity using various dose regimens.
- Trial name
- NCT06976372
- Testing
- AMG 133
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Amgen
Obesity
Safety, Pharmacokinetics and Pharmacodynamics Study to Evaluate BMS-830216 in Obese Subjects
The purpose of this study is to evaluate the safety, tolerability and effect on body weight and other obesity-related factors of different doses of BMS-830216, compared to placebo.
- Trial name
- NCT00909766
- Testing
- BMS-830216
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Obesity, Overweight
Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1)
This study is being conducted to see if semaglutide tablets can be used as a treatment to help people living with overweight or obesity lose weight. This study will look at the change in participants body weight.
- Trial name
- OASIS 1 (NCT05035095)
- Testing
- Oral semaglutide
- Where
- 56 sites in United States, Canada and 7 more
- Volunteers
- 667 people
- Sponsor
- Novo Nordisk A/S
Obesity
A Long-Term Study To Examine The Effects Of CP-945,598 On Weight Loss And Safety
The purpose of this study is to examine the long-term weight loss and safety of CP-945,598 in obese adults
- Trial name
- NCT00375401
- Testing
- CP-945,598 Treatment A, CP-945,598 Treatment B
- Where
- 82 sites in United States, Canada
- Volunteers
- 2,536 people
- Sponsor
- Pfizer
Healthy, Obesity
A Pharmacokinetic Study to Compare the Dosing of Valproic Acid in Subjects With Different Body Weights
The purpose of this study is to compare the blood levels of valproic acid in subjects with different body weights and to evaluate whether the pharmacokinetic parameters of this drug is altered in the obese population.
- Conditions
- Healthy, Obesity, Pharmacokinetics
- Trial name
- NCT00298857
- Testing
- Valproic acid
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Northwell Health