Clinical trials: Obese Subjects
Overweight, Obesity
A Research Study Looking at the Comparability (Bioequivalence) of Two Forms of Semaglutide in Two Different Pen-injectors in People With Overweight or Obesity
The study will look at how two different forms of semaglutide reach and stay in the blood after injection. None of the two forms of semaglutide have been approved by the authorities to treat obesity, but it has been approved as a…
- Trial name
- NCT04187300
- Testing
- Semaglutide
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus
Preventing Renal Functional Abnormalities With Calorie Restriction in Subjects With Abdominal Obesity and Type 2 Diabetes at Increased Renal and Cardiovascular Risk
The study investigates whether a caloric restricted dietary regime can prevent onset and/or progression of chronic kidney disease in type 2 diabetic patients with abdominal obesity, through the amelioration of concomitant…
- Trial name
- CRESO (NCT01213212)
- Testing
- Caloric restriction, No intervention
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Obesity, Type 2 Diabetes
Characterization of Metabolic Biomarkers in Varying Subjects
Traditional dietary, lifestyle, behavioral and pharmacologic treatment strategies have proven relatively ineffective for treating obesity, and once metabolic abnormalities such as Type 2 Diabetes (T2D) develop, definitive…
- Trial name
- NCT01199692
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- CPL Associates
Overweight or Obesity
Efficacy and Safety of HRS9531 Injections in Overweight or Obese Subjects
To assess the efficacy of HRS9531 injection compared with placebo in weight reduction in overweight or obese subjects after 36 weeks of treatment.
- Trial name
- NCT06054698
- Testing
- HRS9531 injection
- Where
- 4 sites in China
- Volunteers
- 61 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Obesity
Effect of Bitter in Overweight Female Volunteers
We want to investigate whether an acute administration of hydroxychloroquine sulphate affects hedonic food intake, appetite related sensations and gastrointestinal hormone release in overweight female subjects.
- Trial name
- PLAQOW (NCT04005781)
- Testing
- Hydroxychloroquine sulphate
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity, Diabetes
Gelesis Glycemic Index Study
A study to determine glucose and insulin responses to 50g and 100 g of carbohydrate with and without Gelesis200.
- Conditions
- Obesity, Diabetes, PreDiabetes
- Trial name
- GLIDE (NCT03124134)
- Testing
- Gelesis200
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gelesis, Inc.
Cystic Fibrosis-related Diabetes, Cystic Fibrosis
SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes
This will be a placebo-controlled, randomized, double blind, crossover study with a 4 week wash out period. Collect pilot data on the safety, tolerability, and feasibility of empagliflozin therapy in overweight/obese patients…
- Trial name
- NCT06149793
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Diabetes, Hypertension
FFA Hypertension and Inflammation in Lean and Obese Subjects
Although a large number of obese patients develop high blood pressure, the cause is unknown. The purpose of this study is to look at the effect of high fatty acids (a type of fat) in the development of high blood pressure in…
- Conditions
- Diabetes, Hypertension, Obesity
- Trial name
- FFAADA (NCT00721617)
- Testing
- Intralipid 20%, Normal Saline, Oral fat load
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Obesity
Effects of Beta-glucan on Energy Intake and Satiety
The purpose of this study is to address the effect of consuming 4g of soluble fibre beta-glucan at breakfast on satiety and food intake.
- Trial name
- NCT02637388
- Testing
- Oatwell28 Oatwell Original Powder, Control Breakfast
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Overweight, Obesity
T-helper 2 (Th2) Cytokine Responses in Overweight/Obese Subjects
Cytokines are chemicals that are naturally made by your body. Certain cytokine levels are changed in the blood of patients who develop allergies and/or asthma.
- Trial name
- NCT02085759
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- West Penn Allegheny Health System
Overweight, Obesity
Exploratory Study to Evaluate Various Pharmacodynamic Effects of Subcutaneously Infused or Injected Pramlintide in Obese Subjects
This exploratory study is designed to evaluate various pharmacodynamic effects of subcutaneously (SC) infused or injected pramlintide in obese, nondiabetic male and postmenopausal female (not on hormone replacement therapy)…
- Trial name
- NCT00444561
- Testing
- pramlintide acetate
- Where
- 10 sites in United States
- Volunteers
- 184 people
- Sponsor
- AstraZeneca
Overweight and Obesity
Evaluation of Obex® in Overweight and Obesity
Obesity is an important and growing worldwide Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer Diverse adverse events have been reported with the use of antiobesity…
- Trial name
- NCT03541005
- Testing
- Obex
- Where
- Cuba
- Volunteers
- 160 people
- Sponsor
- Catalysis SL
Obesity, Nutritional Deficiencies
Assessment of Nutritional Status After Gastric Bypass Surgery
This study is aimed at assessing how Roux-en-Y gastric bypass (RYGP) impacts on energy and nutrients' intake, energy expenditure, and nutritional status in obese patients.
- Trial name
- NCT01891591
- Testing
- Roux-en-Y gastric bypass (RYGP)
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University of Lausanne
Insulin Resistance, Obesity
Research on the Nature, Diagnosis, and Treatment of Obesity and Diabetes
The purpose of this study is to determine whether the level of FOXA2 expression in fat tissue is a biomarker of insulin resistance.
- Trial name
- NCT00229268
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity, Diabetes Mellitus, Type 2
A Study on Efficacy and Safety of Topiramate OROS Controlled-Release in Obese, Type 2 Diabetic Subjects Managed With Diet or Metformin
The purpose of this study is to evaluate the effectiveness and safety of a topiramate controlled-release formulation in the treatment of obese, type 2 diabetic patients managed with diet alone or combined with metformin.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Diabetes Mellitus, Adult-Onset
- Trial name
- NCT00231647
- Testing
- topiramate
- Volunteers
- 113 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Metabolic Syndrome X
Effects the Glycemic Index on Metabolic Risk Markers
Recent population studies have shown that the glycemic index (GI) of food products is positively associated with the risk of developing type 2 diabetes and cardiovascular disease (CVD).
- Trial name
- NCT00695825
- Testing
- Low GI+high GI, High GI+low GI
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes, Obesity
Resveratrol in Type2 Diabetes and Obesity
The main objective of this study is to investigate the effect of resveratrol (plant derived food supplement) on inflammatory mediators and insulin resistance at the cellular and molecular level in obese non diabetic and type 2…
- Conditions
- Type 2 Diabetes, Obesity, Insulin Resistance
- Trial name
- NCT01158417
- Testing
- Resveratrol 40 mg oral three times a day, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Obesity
Study of the Blood Levels and Effects of ATL-962 on Fat Excretion in Obese Subjects
The purpose of this study is to investigate the amount of metabolites of ATL-962 in the blood and to investigate the effect of ATL-962 on the amount of fat that is excreted in the faeces in subjects who are obese
- Trial name
- NCT00148382
- Testing
- ATL-962
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Alizyme
Obesity&T2D
Bioequivalence Study of GZR18 Injection Before and After CMC Change
This is an open-label, randomized, single-dose, parallel comparison bioequivalence study conducted in healthy adult male subjects.
- Trial name
- NCT07355738
- Testing
- GZR18 injection A, GZR18 injection B
- Where
- China
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Gan & Lee Pharmaceuticals.
Obesity
Efficacy and Safety Study of Sibutramine in Overweight Non-Diabetic Malaysian Population
The primary objective of this study was to evaluate the efficacy and the safety of sibutramine vs. placebo in combination with a hypocaloric diet on weight-loss in overweight and obese Malaysian subjects.
- Trial name
- NCT00677391
- Testing
- Sibutramine
- Volunteers
- 103 people
- Sponsor
- Abbott