Clinical trials: Obese Subjects
Obese
A Study of Distal Jejunal-release Dextrose in Obese Participants
The primary purpose of the study is to evaluate the efficacy and safety of APHD-012 (distal jejunal-release dextrose [Aphaia technology, AT]) in obese participants.
- Trial name
- NCT05385978
- Testing
- APHD-012, APHD-012P
- Where
- 9 sites in Georgia, Germany and 1 more
- Volunteers
- 150 people
- Sponsor
- Aphaia Pharma US LLC
Type 2 Diabetes, Obesity
Exercise Training and Cardiovascular Function in Obesity and in Type 2 Diabetes
Obesity and diabetes increase cardiovascular risk by complex and incompletely known mechanisms. The aims of this study are : 1. to compare cardiac and vascular functions at rest and during exercise in 4 groups of age-matched men…
- Trial name
- NCT00264589
- Testing
- 8 weeks individualized training program
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Nutritional Intervention, Nutritional and Metabolic Diseases
Comparison of Postprandial Inflammation in Lean and Obese Subjects
The purpose of this study is to quantify the systemic inflammatory and metabolic response of lean subjects and obese subjects to the ingestion of three caloric doses of a high-fat meal.
- Conditions
- Nutritional Intervention, Nutritional and Metabolic Diseases, Obesity
- Trial name
- NCT01446068
- Testing
- High-fat meal
- Where
- 2 sites in Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Agroscope Liebefeld-Posieux Research Station ALP
Asthma
Oral Probiotic Administration to Modulate the Airway Microbiome in Obese Asthmatic Subjects
Obesity is a major health concern in the Deep South resulting in a growing number of metabolic disorders that strain the resources of our healthcare system. Obesity is recognized as a major risk factor for asthma.
- Trial name
- NCT03157518
- Testing
- Seeking Health Probiota Bifido
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
PreDiabetes, Blood Glucose, High
Investigation of Cinnamon Spice on Glucose Tolerance in Subjects With Pre-diabetes
This study aims to determine whether the effectiveness of cinnamon spice capsules vs. placebo capsules on glucose tolerance in prediabetic subjects who are overweight or obese.
- Trial name
- CINNII (NCT04342624)
- Testing
- Cinnamon
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Overweight and Obesity
A Research Study of How NNC0174-0833 Behaves in Chinese Volunteers Who Are Normal Weight, Overweight or With Obesity
The aim of this study is to look at how the study medicine behaves in participants body and how it is removed from their body. The study compares three different doses of the study medicine in Chinese healthy men.
- Trial name
- NCT05254158
- Testing
- NNC0174 0833
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Obesity
To Determine Tolerability to Glucagon Infusion in Obese Subjects
To further understand the tolerability of glucagon.
- Trial name
- GIO (NCT02817659)
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity
A Study To Examine The Efficacy And Safety Of Pramlintide+Metreleptin In Obese Subjects
Following screening, eligible subjects will be enrolled into a 6-week Low Calorie Diet (LCD) lead-in period. Subjects who lose at least 2% of their body weight at the end of the 6-week LCD lead-in period will be randomized to 1…
- Trial name
- NCT01235741
- Testing
- Pramlintide+Metreleptin
- Where
- 18 sites in United States
- Volunteers
- 213 people
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus
A Single and Multiple-Dose Study of MK-8521 in Healthy and Obese Males (MK-8521-002)
This study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of MK-8521. Part 1 primary hypothesis: Administration of single subcutaneous (SC) doses of MK-8521 is sufficiently safe and well- tolerated…
- Trial name
- NCT02055547
- Testing
- MK-8521 35μg, MK-8521 100μg, MK-8521 125μg
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Obesity
Polyglucosamine L112 in Overweight and Obese Subjects
This research proposes as its main purpose to evaluate the effectiveness of the intake of Polyglucosamine at a dose of 3 g / day on weight loss in a group of subjects suffering from overweight and mild obesity (BMI between 25 and…
- Trial name
- NCT05022732
- Testing
- Polyglucosamine L112
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Type 2 Diabetes Mellitus
Study To Investigate The Safety And Metabolism Of GSK376501 In Overweight Subjects
This study represents the second Phase 1 study with GSK376501 and the goal is to further evaluate its safety and tolerability. The way the human body processes GSK376501 will also be determined.
- Trial name
- NCT00495014
- Testing
- GSK376501
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Overweight and Obesity
Efficacy and Safety of Glucosanol™ in Body Weight Reduction
It was proven in a previous clinical study that Glucosanol™ is effective and safe in reducing weight in the overweight and obese.
- Trial name
- NCT02930668
- Testing
- Glucosanol 350mg, Glucosanol 500mg
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Obesity, Nutritional Intervention
Postprandial Blood Cell Transcriptome of Normal Weight and Obese Subjects to 3 Caloric Doses of a High-fat Meal
The study will quantitatively evaluate the metabolic response of normal weight and obese subjects to three high-fat meals differing in caloric dose by analysing the postprandial blood transcriptome.
- Trial name
- NCT01995110
- Testing
- high-fat meal A, high-fat meal B, high-fat meal C
- Where
- 2 sites in Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Agroscope Liebefeld-Posieux Research Station ALP
Obesity, Overweight
Study to Examine Safety, Tolerability and Effect on Body Weight of Subcutaneous AC2307 in Obese or Overweight Subjects
A randomized, double-blind, placebo-controlled, parallel-group, dose-ranging study to examine the safety, tolerability, and effect on body weight of subcutaneous AC2307 in obese or overweight subjects.
- Trial name
- NCT00785408
- Testing
- AC2307
- Where
- 18 sites in United States
- Volunteers
- 273 people
- Sponsor
- AstraZeneca
Diabetes, Hypertension
FFA Hypertension and Inflammation in Lean and Obese Subjects
Although a large number of obese patients develop high blood pressure, the cause is unknown. The purpose of this study is to look at the effect of high fatty acids (a type of fat) in the development of high blood pressure in…
- Conditions
- Diabetes, Hypertension, Obesity
- Trial name
- FFAADA (NCT00721617)
- Testing
- Intralipid 20%, Normal Saline, Oral fat load
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Obesity
Relationship Between Skeletal Muscle Mass and Interventricular Septum Thickness in Apparently Healthy Overweight and Obese Subjects
The study was aimed at investigating the relationship between skeletal muscle mass and interventricular septum thickness in overweight and obese subjects (BMI≥25)
- Trial name
- NCT04264091
- Testing
- Observational
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Metabolic Syndrome X
Effects the Glycemic Index on Metabolic Risk Markers
Recent population studies have shown that the glycemic index (GI) of food products is positively associated with the risk of developing type 2 diabetes and cardiovascular disease (CVD).
- Trial name
- NCT00695825
- Testing
- Low GI+high GI, High GI+low GI
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity
A Study to Characterise the Physiology of Weight Loss and Regain Under Dietary, Behavioural and Pharmacological Interventions in Healthy Obese Subjects
Approximately 60 obese, but otherwise healthy, subjects will be assessed in this benchmark study to investigate the physiological changes associated with weight loss and regain.
- Trial name
- NCT01597609
- Testing
- sibutramine
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity
Effects of Plasmalogen on Obese Subjects
This is a 12-week, randomized, double-blind, placebo-controlled study to evaluate the effects of scallop-derived plasmalogen on brain fatigue, body weight and changes in blood plasmalogen in obese subjects aged 20-75 years old.
- Trial name
- NCT03295188
- Testing
- Plasmalogen
- Where
- Japan
- Volunteers
- 83 people
- Sponsor
- Japanese Plasmalogen Society
Obesity; Excess Calories, Overweight and Obesity
Efficacy and Safety of Litramine in 1 Year Weight Loss Study
To evaluate the efficacy of Litramine in reducing body weight in the context of an energy-restricted diet in overweight and moderately obese subjects
- Conditions
- Obesity; Excess Calories, Overweight and Obesity, Weight Loss
- Trial name
- NCT03227276
- Testing
- Litramine
- Where
- Germany
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- InQpharm Group