Clinical trials: Obese Subjects
Appetite Regulation, Obesity
Effect of Oligofructose on Appetite in Overweight Subjects
This study seeks to look into the effects of oligofructose supplementation on appetite, energy intake, and body weight and body composition in overweight subjects.
- Trial name
- NCT00912197
- Testing
- Oligofructose
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Overweight, Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD)
A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease （MAFLD）
This is a multicenter, randomized, open-label Phase 3 clinical study comparing the efficacy and safety of IBI362 9 mg QW versus Semaglutide 2.4 mg QW in overweight or obese (BMI≥27kg/m2) MAFLD subjects.
- Trial name
- NCT06884293
- Testing
- IBI362, semaglutide
- Where
- China
- Volunteers
- 479 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Hypertension
Safety and Efficacy Study of BMS-823778 to Treat Uncontrolled High Blood Pressure in Overweight and Obese Patients
The purpose of this study is to determine whether BMS-823778 is safe and effective in the treatment of hypertension in overweight and obese patients.
- Trial name
- NCT01602367
- Testing
- BMS-823778
- Where
- 35 sites in United States, Colombia and 3 more
- Volunteers
- 7 people
- Sponsor
- Bristol-Myers Squibb
Hypertriglyceridemia, Overweight or Obesity
Intermittent Fasting in Hypertriglyceridemic Overweight or Obese Subjects
some studies have shown similar effects of intermittent fasting and continuous caloric restriction on body weight and plasma lipid profile, but there is still a wide controversy.
- Trial name
- NCT04143971
- Testing
- intermittent fasting diet, low calorie diet
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shahid Beheshti University
Healthy Subjects, Obesity
Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or Without Diabetes
The phase 1 portion of the study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of TLC-6740 after single- and multiple-ascending doses in healthy subjects.
- Conditions
- Healthy Subjects, Obesity, Type 2 Diabetes
- Trial name
- NCT05822544
- Testing
- TLC-6740 Oral Solution, TLC-6740 Tablet, Drug Metabolizing Enzyme
- Where
- 4 sites in New Zealand
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- OrsoBio, Inc
Bstructive Sleep Apnea (OSA) and Obesity
A Phase III Study Evaluating the Efficacy and Safety of HRS9531 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity
A Phase III Study Evaluating the Efficacy and Safety of HRS9531 Injection in Subjects with Obstructive Sleep Apnea (OSA) and Obesity
- Trial name
- NCT06974851
- Testing
- HRS9531
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Obesity
Effects of Mobile Application-based Lifestyle Counselling on Body Weight Loss in Obese Subjects
The aim of the trial is to study the effect of a mobile application-based lifestyle change program on body weight loss in adult subjects with obesity.
- Trial name
- NCT04558801
- Testing
- Mobile application-based lifestyle change program
- Where
- Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Obesity, Overweight
A Study of Tirzepatide in Overweight and Very Overweight Participants
The main purpose of this study is to measure the effect of tirzepatide on food intake in participants who are overweight or very overweight.
- Trial name
- NCT04311411
- Testing
- Tirzepatide, Liraglutide
- Where
- 3 sites in United States
- Volunteers
- 114 people
- Sponsor
- Eli Lilly and Company
Obesity
Effect of Coffee and Agave Inulin-based Beverage on Appetite in Adults With Obesity.
Nutritional treatment is key in managing obesity; however, the lack of fullness or satiety signals may affect adherence to this treatment.
- Trial name
- NCT06527209
- Testing
- Coffee and agave inulin-based beverage (A), Control beverage (B)
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Obesity
Enteroendocrine Cells Before and After Sleeve Gastrectomy
Morbidly obese patients exhibit impaired secretion of satiation hormones which may contribute to the development of obesity. Bariatric surgery is associated with weight loss and dramatic increase in the secretion of satiation…
- Trial name
- NCT02589587
- Testing
- sleeve gastrectomy, no intervention
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Prediabetic State
Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Pre-Diabetic Subjects
Branching chain amino acids (BCAA) have both beneficial and detrimental effects of on metabolism have been established and therefore warrants further investigation.
- Trial name
- BCAA (NCT02684565)
- Testing
- BCAA High Protein supplement, BCAA Low Protein supplement
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Obesity
Effect of Bitter in Overweight Female Volunteers
We want to investigate whether an acute administration of hydroxychloroquine sulphate affects hedonic food intake, appetite related sensations and gastrointestinal hormone release in overweight female subjects.
- Trial name
- PLAQOW (NCT04005781)
- Testing
- Hydroxychloroquine sulphate
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Insulin Resistance
Study In Patients With Insulin Resistance
Fluid management study in patients with insulin resistance.
- Trial name
- NCT00197132
- Testing
- Avandia
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- GlaxoSmithKline
Stroke, Hypertension
DELPHI in Subjects at Risk for Stroke and Dementia
The DELPhi system is a software device that is used for the noninvasive evaluation of brain plasticity and connectivity. The DELPhi software uses EEG and TMS devices as accessories.
- Conditions
- Stroke, Hypertension, Diabete Mellitus, Dyslipidemias
- Trial name
- NCT03884647
- Testing
- DELPhI system
- Where
- 4 sites in United States, Israel
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Obesity
TIFACT Study - Tissue Factor Expression by Adipose Tissue in Extremely Obese Subjects.
Tissue factor is the main activator of coagulation cascades. Excessive tissue factor expression is made responsible of thrombosis in a number of clinical situations including thrombosis in contact with atherosclerotic plaques.
- Trial name
- NCT00379704
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes, Morbid Obesity
Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study
Glycaemia, insulin secretion and action in morbidly obes subjects with type 2 diabetes after sleeve gastrectomy ond Roux-en-Y gastric bypass: A randomised single centre study.
- Trial name
- OSEBERG (NCT01778738)
- Testing
- Bariatric surgery, either gastric bypass surgery or sleeve gastrectomy, Sleeve gastrecomy, Bastric bypass
- Where
- Norway
- Volunteers
- 125 people
- Sponsor
- Sykehuset i Vestfold HF
Overweight and Obesity
Dietary Intervention With Probiotic Pasta and Evaluation of the Effects on Metabolic and Inflammatory Status
This study aims to investigate the effects of daily consumption for 4 weeks of a probiotic durum wheat pasta vs a conventional durum wheat pasta without probiotics on fasting metabolic parameters and inflammatory status, on gut…
- Trial name
- ProPas (NCT04962633)
- Testing
- Probiotic Pasta, Control Pasta
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Metabolic Syndrome
The Effect of Metamin 3D on the Lipid and Glucose in Subjects With Metabolic Syndrome
To evaluate the effect of Metamin 3D on improvement of glucose and lipid on Taiwanese subjects with metabolic syndrome.
- Trial name
- NCT01120873
- Testing
- Metamin 3D
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Taichung Veterans General Hospital
Supplementation, Obesity
Clinical Trial to Analyze the Efficacy of a Supplement Extracted From Persimmon on Overweight / Obesity.
Randomized, controlled, double-blind clinical trial, with two parallel branches depending on the product consumed (experimental product and placebo product) and single-center, to measure the efficacy of a supplement extracted…
- Trial name
- PERSOB (NCT05750342)
- Testing
- Experimental Product Caqui
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Prader-Willi Syndrome, Obesity
Double-Blind, Placebo Controlled, Phase 3 Trial of ZGN-440 (Beloranib) in Obese Subjects With Prader-Willi Syndrome
The purpose of this study is to evaluate efficacy and safety of ZGN-440 (beloranib) in obese adolescent and adult subjects with Prader-Willi Syndrome.
- Trial name
- bestPWS (NCT02179151)
- Testing
- ZGN-440 for Injectable Suspension
- Where
- 15 sites in United States
- Volunteers
- 108 people
- Sponsor
- Zafgen, Inc.