Clinical trials: Obesity, Adolescent, open to volunteers
Pediatric Obesity, Metabolic and Bariatric Surgery
Early Reinitiation of Semaglutide Post-Sleeve Gastrectomy in Youth
This is a Phase 3a, randomized, parallel-controlled trial designed to compare the early re-initiation of semaglutide, starting two weeks after sleeve gastrectomy, to standard care (no pharmacotherapy following surgery).
- Conditions
- Pediatric Obesity, Metabolic and Bariatric Surgery, Semaglutide
- Trial name
- NCT06934655
- Testing
- Semaglutide 2.4 mg
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Hospital Los Angeles
Pediatric Obesity
Use of Continuous Glucose Monitors in Children and Adolescents With Obesity
To study if continuous glucose monitors are feasible for use in children and adolescents with obesity.
- Trial name
- CGM (NCT06254768)
- Testing
- Continuous glucose monitor
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity (Disorder)
JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity
The Joule MARS study is a single center, randomized, open label clinical trial aiming to explore the metabolic adaptations that occur in response to weight management in adolescents with obesity.
- Trial name
- JOULE-MARS (NCT06852391)
- Testing
- Semaglutide Pen Injector, Behavioural Lifestyle Program (BLP)
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- McMaster University
Obesity and Overweight
Effect of Simulated Weight Loss on the Energy Cost of Locomotion in Overweight or Obese Adolescents
Current literature suggests that part of the energy response to weight loss is not due to changes in fat mass and lean mass, but rather to a homeostatic adaptation aimed at limiting or even preventing weight loss and preserving…
- Trial name
- DELOAD (NCT07155746)
- Testing
- Incremental walking exercise on an AlterG treadmill (anti-gravity)
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Emile Roux
Obesity/Therapy
Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity
Glucagon-like peptide 1 receptor agonists (GLP-1RA), such as Ozempic and Wegovy, have been rapidly adopted for the treatment of obesity in both youth and adults.
- Trial name
- PLASTIC (NCT07021937)
- Testing
- Semaglutide 1.7mg subcutaneous
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Overweight Adolescents, Underweight
Building Healthy Food Environment in Schools: Evaluating Co-created Interventions in Low Resource Settings. #BetterNutrition4Adolescent
The goal of this clinical trial is to learn if a multicomponent nutrition program developed together with the students, parents, teachers and canteen operators will improve nutrition status of adolescents.
- Conditions
- Overweight Adolescents, Underweight, Obese Adolescents
- Trial name
- NCT07332676
- Testing
- Multicomponent school nutrition intervention, Usual nutrition program
- Where
- 2 sites in India, Nepal
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Obese Adolescents, Mental Health
Co-creating School Community Intervention Program on Physical Activity to Increase Health Equity in Children and Adolescents
The goal of this observational and interventional study is to understand whether environmental and behavioral interventions can improve physical activity and health outcomes in children aged 12-16 years attending VDU Atžalynas…
- Trial name
- Connection (NCT07120516)
- Where
- Lithuania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sandra Andrusaityte
Health Behavior, Child Development
Dietary Modulation of Gut Microbiota in Overweight/Obese Adolescents and COVID-19 Infection
Probiotic intervention has been currently suggested to provide supportive benefits in promoting health, including alleviating disease symptoms, protecting against diarrhea and respiratory infection, affecting growth and…
- Conditions
- Health Behavior, Child Development, Adolescent Obesity
- Trial name
- DIVINE (NCT05623007)
- Testing
- Probiotics, Counselling on healthy eating, physical activity, and psychosocial stimulation
- Where
- Indonesia
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Obesity, Childhood
Stanford Healthy Goals Study
Past modest, transient and highly variable outcomes from many behavioral treatments for pediatric obesity may be, in part, because of the psychological barriers children with obesity face when trying to control their weight.
- Trial name
- NCT07839832
- Testing
- Wise interventions -- values self-affirmation and growth mindset -- plus usual care behavioral treatment, Education plus usual care behavioral treatment
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Obesity, Adolescent Obesity
Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents
The study plans to learn more about what happens to the body after bariatric surgery in people 12 to 24 years old. The study aims to understand why people respond differently to bariatric surgery and how to define success beyond…
- Conditions
- Obesity, Adolescent Obesity, Body-Weight Trajectory, Weight Loss Trajectory
- Trial name
- PRESSURE (NCT06575738)
- Testing
- Injectable semaglutide or injectable tirzepatide, Standard postoperative care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Obesity, Weight Gain
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
The goal of the study is to assess how tirzepatide impacts bodyweight and cardiovascular risk factors when used in conjunction with healthy nutrition and physical activity in adolescents with obesity and multiple weight related…
- Trial name
- NCT06439277
- Testing
- Tirzepatide
- Where
- 69 sites in United States, Argentina and 10 more
- Volunteers
- 300 people
- Sponsor
- Eli Lilly and Company
Class I Obesity, Pediatric Obesity
Virtual Housecalls: Redesigning Pediatric Primary Care Adolescent Obesity Treatment
This pragmatic randomized clinical trial tests a novel intensive health behavior and lifestyle intervention, conducted via telehealth, to treat class I adolescent obesity in pediatric primary care.
- Trial name
- VHC (NCT07246603)
- Testing
- Virtual Housecalls
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Adiposity, Childhood Obesity
Early Life Intervention in Pediatrics Supported by E-health
Childhood obesity in early life contributes to the development of specific NCDs, i.e. adult obesity. Unhealthy diet and low level of physical activity are lifestyle risk behaviors associated with chronic, systemic inflammation…
- Conditions
- Adiposity, Childhood Obesity, Adolescent Obesity, Non-communicable Disease
- Trial name
- ELIPSE-I (NCT06208345)
- Testing
- Life-Style app
- Where
- Switzerland
- Volunteers
- 148 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Severe Adolescent Obesity, Adolescent Obesity
Comparison of Day Hospitalization Versus Full-Time Hospitalization in the Treatment of Severe Adolescent Obesity
This multicenter prospective quasi-experimental study aims to compare the effectiveness of day hospitalization versus full-time hospitalization for adolescents with severe obesity.
- Conditions
- Severe Adolescent Obesity, Adolescent Obesity, Pediatric Obesity
- Trial name
- MAROSA (NCT07652190)
- Testing
- Day Hospital Multidisciplinary Care, Full-Time Inpatient Multidisciplinary Care
- Volunteers
- 126 people
- Sponsor
- Fondation Santé des Étudiants de France
Obesity & Overweight
Postprandial Thermogenesis in Obese Adolescents: Effect of Weight Loss
The prevention and management of pediatric obesity require a thorough understanding and consideration of the various components of energy balance (i.e., intake and expenditure) and their interactions.
- Trial name
- TEFAL (NCT07400159)
- Testing
- Anthropometric measurements, Body composition assessment, Leeds Foods Preference Questionnaire
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Emile Roux
Obesity Prevention, School Wellness Policy
Primary Prevention of Obesity in American Indian Youth in Rural Tribal Schools
The goal of this study is to learn if a culturally relevant health promotion curricula prevents obesity among 4th graders in rural tribal schools.
- Trial name
- NCT06864468
- Testing
- Health promotion curricula
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Childhood Obesity
Leipzig Childhood Obesity Study
The aim of this study is to identify polymorphisms that make children and adolescents more prone to obesity and metabolic dysfunction, as well as to identify biomarkers that are linked to causes and consequences of obesity.
- Trial name
- NCT04491344
- Where
- Germany
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Adolescents With Obesity, Adolescents With Overweight & Weight-related Comorbidities
A Study of Ecnoglutide Injection in Overweight or Obese Chinese Adolescents
The aim of the study is to evaluate the safety and efficacy of Ecnoglutide injection in overweight or obese Chinese adolescents
- Trial name
- NCT07836270
- Testing
- Ecnoglutide Injection
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Monogenic Obesity
A Multicenter Pharmacoepidemiological Cohort on Real Life Use of Semaglutide in Adolescents or Adults With Monogenic Obesity
Rare genetic forms of obesity, so called monogenic obesity are linked to alteration in energy balance involving hypothalamic pathways.
- Trial name
- ObGeSema (NCT06380426)
- Where
- 2 sites in France
- Volunteers
- 175 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Physical Activity, Childhood Obesity
The LEADS Trial (Linking Exericise for Advancing Daily Stress Management)
Chronic stressors have wide-reaching harmful effects on the physical, social, and psychological well-being of many African American (AA) families.
- Trial name
- LEADS (NCT07176234)
- Testing
- Treatment, Health Education
- Where
- 2 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of South Carolina