Clinical trials: Obesity, Adolescent
Obesity, Childhood, Pediatric Obesity
Treatment Efforts Addressing Child Weight Management by Unifying Patients, Parents & Providers
The US Preventive Services Task Force (USPSTF) recommends that providers screen children aged 6 years and older for obesity and offer or refer them to a comprehensive behavioral intervention (≥26 hours over a period of up to 12…
- Conditions
- Obesity, Childhood, Pediatric Obesity, Childhood Obesity, Adolescent Obesity
- Trial name
- TEAM UP (NCT03843424)
- Testing
- eSOC program, FBT program
- Where
- 7 sites in United States
- Volunteers
- 1,460 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Adolescent Obesity, Pre Diabetes
- Trial name
- NCT05008276
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Petter Bjornstad
Obesity
New Moves - Obesity Prevention Among Adolescent Girls
The New Moves study will evaluate the impact of a school based program for inactive high school girls who are overweight or at risk for being overweight due to low levels of physical activity.
- Trial name
- NCT00250497
- Testing
- New Moves
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Overweight/Obesity, Adolescent
Oxfordshire Sedentariness, Obesity & Cardiometabolic Risk in Adolescents - a Trial of Exercise in Schools
Obesity is a major cardiovascular disease (CVD) risk factor that is rising fastest in children. Prevention of its damaging effects should begin earlier before they become irreversible.
- Trial name
- OxSOCRATES (NCT04118543)
- Testing
- Intervention Group
- Where
- United Kingdom
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cardiovascular Diseases
Effect of Exercise or Metformin on Nocturnal Blood Pressure and Other Risk Factors for CVD Among Obese Adolescents
The objective is to, among obese adolescents, study impact of regular physical activity or metformin therapy on nocturnal blood pressure and related cardiovascular disease risk factors.
- Trial name
- NCT00889876
- Testing
- Metformin group, Exercise
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Maria Sandberg Westerstahl
Overweight and Obesity, Adolescent Obesity
The BEE-Power Study (Boosting Exercise for Excellent Pediatric Blood Pressure)
The goal of this study is to compare two types of exercises, isometric exercise (like squats and planks) and aerobic exercise (such as running), to see which one is more effective at improving blood pressure in teenagers aged 13…
- Conditions
- Overweight and Obesity, Adolescent Obesity, Exercise
- Trial name
- NCT06444464
- Testing
- Aerobic exercise, Isometric exercise
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Childhood Obesity, Endothelial Dysfunction
Mechanisms of Atherogenesis During Post-prandial Time in Childhood Obesity
Childhood obesity is increasing at a fast pace, together with its complications. The aim of the present study is to assess several candidate triggering agents, mechanisms and intermediate phenotypes of atherosclerosis during the…
- Conditions
- Childhood Obesity, Endothelial Dysfunction, Inflammation, Insulin Resistance
- Trial name
- NCT01502826
- Testing
- standardized mixed meal
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Pediatric Obesity
Medications After Adolescent Bariatric Surgery
This study will assess the feasibility to assess practicality of early weight loss medication usage in adolescent patients post-VSG with inadequate weight loss.
- Trial name
- MAABS Protocol (NCT04572217)
- Testing
- Topiramate, Phentermine
- Where
- United States
- Sponsor
- Janey Pratt
Non-Alcoholic Fatty Liver Disease, Childhood Obesity
Clinical Epidemiology of NAFLD in Children and Adolescents
Background: Non-alcoholic fatty liver disease (NAFLD) is rapidly increasing alongside overweight and obesity, not only in adults but also in children and adolescents.
- Trial name
- LiverKids (NCT05526274)
- Testing
- Vibration-Controlled Transient Elastography (VCTE) with Controlled Attenuation Parameter (CAP)
- Where
- Spain
- Volunteers
- 2,866 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Prevention, Type2Diabetes
Dialectal Behaviour Therapy to Enhance Health Behaviour Change for Adolescents Living With Obesity (DIRECTION Trial)
This research is being conducted to evaluate emotion-focused therapy that incorporates elements of mindfulness, distress tolerance, and relationship support.
- Trial name
- NCT05338944
- Testing
- Dialectical behavioral therapy, Lifestyle
- Where
- 3 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Morbid Obesity, Obstructive Sleep Apnea Syndrome
LAGB as a Treatment for Morbid Obesity in Adolescents
Laparoscopic adjustable gastric banding (LAGB) has been used worldwide to help selected morbidly obese adults to lose weight. The FDA has approved LAGB only for patients 18 years or older.
- Conditions
- Morbid Obesity, Obstructive Sleep Apnea Syndrome, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01045499
- Testing
- Laparoscopic adjustable gastric banding (Allergan Lap Band)
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Jeffrey L Zitsman, MD
Bipolar Youth Treated With Second-generation Antipsychotics
SGA-induced Metabolic Syndrome in Bipolar Youth
The investigators tested the hypothesis that long-chain omega-3 (LCn-3) fatty acid supplementation will attenuate the adverse cardiometabolic effects of second-generation antipsychotics exposure in first-episode adolescent manic…
- Trial name
- NCT01858948
- Testing
- Omega, Quetiapine fumarate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Cincinnati
Obesity & Overweight
Effects of Exercise on Lipids and Endothelial Function in Youth
This study is for individuals who have a BMI that is at or above the 95th percentile and are participating in the Cincinnati Children's Hospital Healthworks! Structured weight loss program.
- Trial name
- NCT07409064
- Testing
- Exercise Program
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity, Overweight
Addressing Anxiety and Stress for Healthier Eating in Teens
Project ASSET will explore the preliminary efficacy of interpersonal therapy, when compared with cognitive behavioral therapy, for reducing anxiety symptoms, preventing excess weight gain, and reducing cardio-metabolic risk in…
- Conditions
- Obesity, Overweight, Anxiety, Mental Disorders
- Trial name
- ASSET (NCT05038033)
- Testing
- Interpersonal Psychotherapy (IPT), Cognitive Behavioral Theory (CBT)
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Metis Foundation
Cardiovascular Diseases, Heart Diseases
Obesity Prevention for Pre-Adolescents
To develop and evaluate, in a randomized controlled trial, a comprehensive obesity prevention program for third, fourth and fifth grade students.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00185978
- Testing
- diet, physical activity, reduced sedentary behavior
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Stanford University
Overweight, Obesity
Pediatric Obesity Weight Evaluation Registry (POWER) Study
The main objective of this study is to establish a national pediatric obesity registry known as POWER (Pediatric Obesity Weight Evaluation Registry).
- Trial name
- POWER (NCT02121132)
- Where
- 38 sites in United States
- Volunteers
- 4,276 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity & Overweight, Orthodontic Treatment
Impact of Increased Body Mass Index on Adolescent Fixed Orthodontic Treatment. A Prospective Longitudinal Study
The goal of this prospective observational study is to assess the influence of increased body mass index (BMI) on various oral health and orthodontic-related parameters in adolescents undergoing orthodontic therapy (OT) with…
- Trial name
- NCT07217756
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Liver Fat, Type 2 Diabetes
EXIT: Prospective Study of the Response to Exercise
Background : Regular exercise is a cornerstone in the prevention and the management of comorbidities. Unfortunately, the metabolic benefit of exercise training is not universal and varies among individuals.
- Trial name
- EXIT (NCT02204670)
- Testing
- Acute release of irisin after a single exercise session.
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Overweight, Pediatric Obesity
Clinical/Behavioral Approach to Overweight in Latino Youth
This randomized controlled trial tests the efficacy of a culturally and linguistically appropriate, evidence-based intervention to slow weight gain or promote weight loss among overweight 6-9 year old Mexican-American children.
- Trial name
- Luces (NCT02771951)
- Testing
- "Lights of Change", Usual Care
- Where
- United States
- Volunteers
- 297 people
- Sponsor
- San Diego State University
Overweight, Obesity
Effects of Intermittent Caloric Restriction in Youth With Cardiometabolic Risk
This is a randomized controlled pilot study to evaluate the effects of intermittent caloric restriction compared with low carbohydrate diet in youth with cardiometabolic risk.
- Conditions
- Overweight, Obesity, Cardiometabolic Risk
- Trial name
- NCT04011995
- Testing
- Intermittent caloric restriction, Low carbohydrate diet, Health education on reducing the cardiometabolic risk
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Children's Hospital of Fudan University