Clinical trials: Obesity, Infant
Maternal Obesity Complicating Pregnancy, Birth,or Puerperium, Gestational Diabetes Mellitus
An Early-customized Low Glycaemic-index (GI) Diet Prevents LGA Babies in Overweight/Obese Pregnant Women
High pre-pregnancy body mass index (BMI) and excessive gestational weight gain (GWG) are associated with many unfavourable maternal and neonatal outcomes.
- Conditions
- Maternal Obesity Complicating Pregnancy, Birth,or Puerperium, Gestational Diabetes Mellitus, Birthweight, Large for Gestational Age (LGA)
- Trial name
- NCT02750774
- Testing
- Low-glycemic index group, Standard Care Group
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Sleep Apnea, Central, Prader-Willi Syndrome
Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome
The aim of this study is to determine if treatment with Medical Air (21% oxygen in room air) compared to supplemental oxygen (100% oxygen) will lead to similar improvements in the central apnea-hypopnea index (CAHI) for infants…
- Trial name
- NCT03031626
- Testing
- Medical Air vs Oxygen
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- The Hospital for Sick Children
Childhood Obesity
The Bottle Optimization Testing Tiny Little Eaters Study
The researchers will study how babies respond to bottle nipples with different flow rates over a few days, and how this may affect how much milk they drink, their feeding patterns, and their sleep.
- Trial name
- BOTTLE (NCT07665983)
- Testing
- Feeding
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cystic Fibrosis-related Diabetes, Cystic Fibrosis
SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes
This will be a placebo-controlled, randomized, double blind, crossover study with a 4 week wash out period. Collect pilot data on the safety, tolerability, and feasibility of empagliflozin therapy in overweight/obese patients…
- Trial name
- NCT06149793
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Body Weight, Obesity & Overweight
Breastmilk and the Link to Overweight/Obesity and Maternal Diet in the Mother-breastmilk-child Triad
The prospective 5-month follow-up study will involve 150 mother-infant dyads grouped based on maternal baseline BMI category (normal weight, overweight, obesity).
- Conditions
- Body Weight, Obesity & Overweight, Human Milk/Breastfeeding, Body Composition
- Trial name
- BLOOM-Triad (NCT07457515)
- Where
- 4 sites in Canada, Poland
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Warsaw University of Life Sciences
Childhood Obesity, Infant Development
Unintentional Overfeeding of Formula Fed Infants
Although breast milk is recommended exclusively until 6 months of age, two-thirds of infants in the U.S. are fed infant formula.
- Trial name
- Whoa Baby (NCT02701868)
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Childhood Overweight
Effects of Lifestyle Intervention on Childhood Outcomes in LGA Infants
Large-for-gestational-age (LGA) infants have a higher risk of metabolic disease later in life, and their postnatal growth in early childhood may be associated with long-term adverse outcomes.
- Trial name
- NCT04661449
- Testing
- Comprehensive lifestyle intervention
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Obesity
The Sweet PEA Study: Effects of Diet During Pregnancy on Infant Growth and Development.
The purpose of the Sweet PEA Study is to determine whether diet during pregnancy has an effect on infant's growth, body composition, and brain development.
- Trial name
- NCT04674033
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Infant Formula, Growth
Lower Protein Intake and Long-term Risk of Obesity and Cardiovascular Disease
The primary objective of this study is to investigate if consumption of lower protein formula can slow the rate of weight gain of formula-fed infants between 3 and 12 months of age.
- Trial name
- BabyGrowth (NCT03456934)
- Testing
- Modified infant formula, Standard infant formula
- Where
- United Kingdom
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Obesity, Childhood, Obesity
Mother-Baby Study - Observational
The rate of weight gain in the first year of life is risk factor for future obesity. The study will test (1) a model of l mechanisms underlying the development of emotion, attachment, and nutritive intake; and (2) the association…
- Trial name
- NCT06039878
- Testing
- Bonding-Evoked Oxytocin, Distress Relieving Effects of Sucrose, Hedonic Response to Sucrose
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Overweight, Childhood, Obesity in Children
The Bloom Study - a Safe and Healthy Start in Life
The aim of the Bloom Study is to promote healthy weight development among infants through a home-based health promoting intervention implemented in the Danish setting of community health nurses.
- Trial name
- NCT06705400
- Testing
- Multi-behavioural
- Where
- Denmark
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Obesity, Obesity, Infant
Maternal Characteristics Associated With Child Growth and Adiposity
The goal of this observational study is to investigate the concentrations of leptin, insulin, liver expressed antimicrobial peptide 2 (LEAP2), and cortisol in plasma and breast milk and their relationship with eating behavior…
- Trial name
- NCT05798676
- Testing
- overweight/obesity
- Where
- Argentina
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri
Obesity
Optimising Protection for Pregnant Women and Infants With Maternal Vaccination
This study has been designed to investigate if: 1. BMI affects the immunogenicity of influenza and pertussis vaccines given during pregnancy. 2.
- Trial name
- OPTIWIN (NCT03457194)
- Testing
- Quadrivalent Influenza Vaccine, DTP Vaccine (Multiple Actives)
- Where
- Australia
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Women's and Children's Hospital, Australia
Adiposity, Breast Feeding
Mother and Infant Study Cohort (MISC)-
This study aims to explore breastfeeding and complementary feeding practices of mothers in the United Arab Emirates (UAE) and its relation to the early life determinants of obesity and non-communicable diseases (NCDs).
- Trial name
- NCT03578094
- Where
- United Arab Emirates
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Childhood Obesity
Grow2Gether Pilot Study
This is a randomized controlled pilot trial of a peer-based, social media intervention to prevent obesity in infants.
- Trial name
- NCT02037490
- Testing
- Grow2Gether
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- Children's Hospital of Philadelphia
Insulin Resistance, Obesity
Studying Infant Nutrition and Blood Sugar
The purpose of this study is to learn about how breast milk from mothers with insulin-resistance may be different. Investigators are specifically studying insulin concentrations in breast milk.
- Trial name
- NCT03524469
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Infant Obesity, Hepatic Steatosis
TREating Pediatric Obesity
The main aim of the study is to collect preliminary information on the feasibility and efficacy of a time restricted eating intervention in Spanish children and adolescents with obesity and metabolic comorbidities.
- Conditions
- Infant Obesity, Hepatic Steatosis, Metabolic Syndrome, Insulin Resistance
- Trial name
- TREPO (NCT05124847)
- Testing
- Standard Care, Time restricted eating
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Obesity, Weight Gain
Diet, Physical Activity and Breastfeeding Intervention on Maternal Nutrition, Offspring Growth and Development
NCDs are observed mostly in adults, however there is strong evidence that suggests NCDs origin early in life, thus the first 1000 days of life (conception to age 2yrs).
- Conditions
- Obesity, Weight Gain, Metabolic Diseases, Birth Weight
- Trial name
- NCT01916603
- Testing
- Normative Intervention
- Where
- Chile
- Volunteers
- 2,400 people
- Sponsor
- University of Chile
Iron Deficiency Anemia of Pregnancy
Adiposity and Iron Requirements in Pregnancy
This study aims to explore how body fat influences the response to either 25 or 50 mg of daily iron supplements during pregnancy.
- Trial name
- ADIPREG (NCT06425796)
- Testing
- Adiposity and Iron Requirements in Pregnancy (ADIPREG)
- Where
- 3 sites in United Kingdom
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal
Late Gestational Diabetes Mellitus Diagnosis in Obese Women
In the current work, we aim to perform a prospective study that will investigate the relationship between maternal obesity (BMI >30 kg/m2) and morbid obesity (BMI >35 kg/m2) with a late GDM diagnosis (>32 weeks), with an emphasis…
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal, Dystocia, Shoulder, Neonatal Jaundice
- Trial name
- NCT05510518
- Testing
- oral glucose tolerance test (OGTT)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Western Galilee Hospital-Nahariya