Clinical trials: Obesity, Morbid
Morbid Obesity
Oseltamivir Pharmacokinetics in Morbid Obesity
This trial asks the question: do people of much greater than average body weight need more of a drug called oseltamivir than current recommendations suggest.
- Trial name
- OPTIMO (NCT01002729)
- Testing
- Patients with a BMI < 30 given Oseltamivir, Patients with a BMI > 40 given Oseltamivir
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Hypothermia, Morbid Obesity
The Efficacy of External Warming During Laparoscopic Bariatric Surgery
External warming is routinely used in general surgery to offset the deleterious effects of hypothermia. It entails deployment of a disposable, external heating blanket attached to a regulated hot-air pump.
- Conditions
- Hypothermia, Morbid Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03429205
- Testing
- No external heating used during surgery, External heating blanket used during surgery
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Atrial Fibrillation, Morbid Obesity
Bariatric Atrial Restoration of Sinus Rhythm
The objective of this study is to determine whether bariatric surgery followed by Atrial Fibrillation (AF) catheter ablation is superior to AF catheter ablation alone in the management of atrial fibrillation in patients with…
- Trial name
- BAROS (NCT04050969)
- Testing
- Bariatric surgery, Atrial Fibrillation (AF) Catheter Ablation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Morbid Obesity
Changes in Ingestive Behaviour Following Gastric Bypass
The gastric bypass procedure is known to be one of the most successful treatments for morbid obesity and Type 2 diabetes mellitus, and has been shown to decrease appetite, energy intake, body weight and glycemia both in the short…
- Trial name
- NCT03113305
- Where
- 2 sites in Ireland, United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Morbid Obesity
Impact of Reverse Trendelenburg on ONSD in Obesity Surgery
This prospective randomized controlled trial aims to investigate the effect of reverse Trendelenburg positioning applied before pneumoperitoneum on optic nerve sheath diameter (ONSD) and, consequently, intracranial pressure…
- Trial name
- ONSD (NCT07639502)
- Testing
- Pre-pneumoperitoneum Reverse Trendelenburg Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Obesity, Morbid, Diabetes Mellitus Type 2
Gut Hormone Profiling in Obese Patients With Type 2 Diabetes (MK-0000-134)
This study will examine changes in various gut-derived hormones in obese type 2 diabetic patients before and after elective bariatric surgery.
- Trial name
- NCT00957957
- Volunteers
- 22 people
- Sponsor
- Merck Sharp & Dohme LLC
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Lisdexamphetamine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03497169
- Testing
- Lisdexamfetamine Dimesylate
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Morbid Obesity
Bariatric Procedures and Changes in Incretins and Gastric Emptying
The study evaluates the gastric emptying by scintigraphy in patients that had bariatric surgery (RYGB of gastric sleeve) comparing patients with successful and unsuccessful weight loss and in patients before and after the…
- Trial name
- BIG (NCT02539641)
- Testing
- Gastric emptying scintigraphy, Determination of gut hormones
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Rijnstate Hospital
Childhood Obesity
Genetic Determinants and Clinical Consequences of Early-onset Severe Obesity
The aim of the present study is to identify new obesity-related genetic defects and determine their association with clinical manifestations in families with childhood-onset severe obesity.
- Trial name
- PeLi (NCT02645422)
- Volunteers
- 400 people
- Sponsor
- Helsinki University Central Hospital
Morbid Obesity
Efficacy of SASI Bypass in Super Obese Patients
Although previous studies investigated weight loss and improvement in comorbidities after SASI bypass, patients included in these studies had a BMI less than 50 Kg/m2.
- Trial name
- NCT04037670
- Testing
- SASI bypass
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Obesity, Weight Loss
Comparison of Weight Loss Programs for Individuals With Severe Obesity
The purpose of this study is to evaluate the effectiveness of a technology-based system (the Body Media FIT system) for enhancing weight loss in severely obese individuals (BMI: ≥ 40 kg/m2).
- Trial name
- NCT01330329
- Testing
- Standard behavioral treatment, SBT + technology system (SBT+FIT)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The Miriam Hospital
Type 2 Diabetes, Morbid Obesity
Diabetes Remission After RYGBP and RYGBP With Fundus Resection
The goal of this randomized clinical trial is to evaluate glycemic control in patients with morbid obesity and type 2 diabetes after Roux-en-Y gastric bypass (RYGBP) and RYGBP with fundus resection.
- Conditions
- Type 2 Diabetes, Morbid Obesity, Bariatric Surgery
- Trial name
- NCT05854875
- Testing
- Laparoscopic Roux en Y gastric bypass, Laparoscopic Roux en Y gastric bypass with fundus resection
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- University of Patras
Morbid Obesity
The Influence of Aerobic Endurance Training After Roux-en-Y-Gastric Bypass
The aim of this study was to assess the efficiency of aerobic physical exercise (APE) on weight loss, body composition and co-morbidities in patients after laparoscopic Roux-en-Y Gastric bypass (RYGBP).
- Trial name
- AET (NCT00875186)
- Testing
- aerobic endurance training
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Obesity
Metabolomic Fingerprint After Bariatric Surgery
Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity.
- Trial name
- NCT02480322
- Testing
- bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- eSwiss Medical & Surgical Center
Morbid Obesity
Laryngeal Masks for Bariatric Surgery
Obese people pose specific problems as far as the management of airway during surgery. The study aims to compare efficacy and safety of two LMA devices.
- Trial name
- NCT01724970
- Testing
- ProSeal, Supreme LMA
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Padova
Obesity
Deep Brain Stimulation for Human Morbid Obesity
The burden of morbid obesity to the circulatory, endocrine, and locomotor systems, as well as the psychological effects and related health-care costs, are well established in the medical literature.
- Trial name
- BLESS (NCT02232919)
- Testing
- Deep Brain Stimulation
- Where
- Brazil
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hospital do Coracao
Obesity, Morbid
Ultrasound-Guided Erector Spinae Plane Block Versus Modified Thoracoabdominal Block for Analgesia in Obese Patients
Obesity is a complex chronic disease that has become a major public health concern worldwide, with the prevalence of obesity increasing dramatically over the past few decades.
- Trial name
- NCT06841783
- Testing
- nerve block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Bariatric Surgery Candidate, Severe Obesity
Single Anastomosis Duodenal Ileal Bypass (SADI) for Sleeve Revision
The goal of this study is two part: 1) to add to the literature which is still somewhat sparse with numbers of patients undergoing the Single Anastomosis Duodenal Ileal Bypass (SADI) as a revision for laparoscopic sleeve…
- Trial name
- SADI (NCT04165694)
- Testing
- Single Anastomosis Duodenal Ileal Bypass (SADI)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Pulmonary Atelectasis, Respiratory Tract Diseases
Use of Positive Pressure in Morbidly Obese Patients Undergoing Reduction Stomach Surgery
The aim of this study was to investigate the effects of using positive pressure in the preoperative, intraoperative and postoperative morbidly obese individuals undergoing gastroplasty.
- Conditions
- Pulmonary Atelectasis, Respiratory Tract Diseases, Pathological Conditions, Signs and Symptoms
- Trial name
- NCT01786681
- Testing
- Positive pressure
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Morbid Obesity, Cesarean Delivery Affecting Fetus
Effect of CPAP on Fetal pH at Scheduled C-section in Morbidly Obese Women
The objective of our study is to evaluate the effect of CPAP on umbilical cord acid base status in morbidly obese women at the time of scheduled cesarean delivery.
- Trial name
- NCT04993651
- Testing
- CPAP
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Eastern Virginia Medical School