Clinical trials: Obesity, Overweight
Obesity, Overweight
Targeting DNA-methylation Fingerprints Linked to Ultra-Processed Foods Consumption to Prevent Non-communicable Diseases: the METHYL-UP Study
Non-communicable diseases (NCD) are the main health challenge in industrialized countries. However, these diseases are preventable if an intervention based on lifestyle is implemented at the population level.
- Trial name
- METHYL-UP (NCT05319327)
- Testing
- Nutritional intervention, Control
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- IMDEA Food
Insulin Resistance, Obesity
Novel Dietary Interventions for Treating Insulin Resistance
Clinical and rodent studies have demonstrated the impact of specific dietary factors in modulating inflammation-related diseases including insulin resistance, type 2 diabetes, and cardiovascular disease.
- Conditions
- Insulin Resistance, Obesity, Metabolic Syndrome
- Trial name
- NCT02006394
- Testing
- Fish Oil, Polyphenol Capsules, Corn Oil Capsules
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of California, San Diego
Obesity
Hybrid Argon Plasma Coagulation and Endoscopic Sleeve Gastroplasty Trial
This study is being done to evaluate the safety and effectiveness of combined Hybrid Argon Plasma Coagulation (HAPC) and Endoscopic Sleeve Gastroplasty (ESG) for weight loss and improvement in obesity-related co-morbidities…
- Trial name
- HAPCET (NCT05559866)
- Testing
- Apollo ESG with ERBE HAPC, Apollo ESG
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Obesity
A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
This study will look at how well semaglutide helps children and teenagers losing weight. This will be tested by comparing the effect on body weight in children and teenagers taking semaglutide in comparison to placebo, a "dummy"…
- Trial name
- STEP Young (NCT05726227)
- Testing
- Semaglutide
- Where
- 56 sites in United States, Austria and 8 more
- Volunteers
- 212 people
- Sponsor
- Novo Nordisk A/S
Obesity
Catgut Implantation at Acupoints for the Treatment of Simple Obesity
The primary objective of this multicenter randomized controlled trial is to evaluate treatment effectiveness of intervening simple obesity people with catgut implantation at preferred acupoints, which excludes placebo effect; the…
- Trial name
- NCT02936973
- Testing
- Real catgut implantation at acupoints
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Hubei Hospital of Traditional Chinese Medicine
Cardiovascular Diseases, Heart Diseases
Pawtucket Heart Health Program
To conduct a community-based research and demonstration project in cardiovascular disease prevention in the town of Pawtucket, Rhode Island.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypercholesterolemia, Hypertension
- Trial name
- NCT00005151
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cognitive Function and Mood, Cerebral Blood Flow
The Effects of Resveratrol Supplementation on Cognition, Cerebral Blood Flow, Microbiota and Systemic Inflammation.
Previous research shows that a diet high in fat has harmful effects on gut health. This increases the chance of developing obesity-related diseases (such as type 2 diabetes) and disrupts cognition and mood.
- Conditions
- Cognitive Function and Mood, Cerebral Blood Flow, Systemic Inflammation, Gut Microbiota
- Trial name
- NCT03448094
- Testing
- Resveratrol
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Pediatric Obesity
PrOtein and WEight Loss in teenageRs
The aim of the proposed study is to provide important data on weight loss efficacy in overweight and obese adolescents on an isocaloric higher protein diet vs a lower protein diet utilizing the U.S.
- Trial name
- POWER (NCT02079831)
- Testing
- Energy Restriction, Higher protein, Lower Protein
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Overweight, Obesity
Motivational Interviewing for Overweight and Obese Adults at Healthy Life Centers
Overweight and obesity are major public health problems associated with increased morbidity and mortality. Motivational interviewing is a patient-centered counseling approach that may improve lifestyle behaviors and weight…
- Trial name
- MI-HLC (NCT07745231)
- Testing
- Motivational Interviewing, Routine Nutrition Counseling
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Sakarya University
Obesity
Dopamine Action on Metabolism in Relation to Genotype
Obesity is a widespread disease with increasing prevalence and associated with serious secondary complications. So far, the origin of the disease, regardless of an existing positive energy balance, is not fully understood.
- Trial name
- NCT03525002
- Testing
- Bromocriptine
- Where
- 3 sites in Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
Central Obesity
Electro-acupuncture for Central Obesity
In this study, a 8-week, single blinded, randomized controlled clinical trial will be conducted to examine the efficacy and safety of body acupuncture in the treatment of central obesity in Hong Kong.
- Trial name
- NCT03815253
- Testing
- acupuncture
- Where
- Hong Kong
- Volunteers
- 168 people
- Sponsor
- Hong Kong Baptist University
Nutritional and Metabolic Diseases
Low-calorie Sweeteners and Adipose Signaling
The purpose of this study is to determine whether eight weeks of low-calorie sweetener (LCS) exposure exerts cardiovascular and/or metabolic effects among LCS-naïve overweight and obese adolescents and young adults.
- Trial name
- NCT03125356
- Testing
- Diet Soda
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- George Washington University
Overweight and Obesity, Healthy
A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants Receiving a Glucagon-like Peptide-1 (GLP-1) Agonist
Adult participants with BMI between 22 - 35 kg/m2 will be enrolled and randomized to receive either NG101 (20 mg twice daily [BID]) or placebo for 5 days beginning on Day 1.
- Trial name
- NCT06500429
- Testing
- NG101, Semaglutide Injectable Product
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Neurogastrx, Inc.
Endometrial Receptivity
Microbiome and Endometrial Receptivity in Obese Infertile Women
The objective of this project is the identification and quantification of the main bacterial communities present in the endometrial microbiota in obese infertile patients, to assess if there is an alteration of their composition…
- Trial name
- NCT03493529
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Obesity
The Natriuretic Peptide Response to Saline Infusion
The primary objective is to evaluate the overarching hypothesis that obese and black individuals have relatively lower circulating natriuretic peptide levels compared with lean and white individuals.
- Trial name
- NCT04223531
- Testing
- Normal Saline 0.9% Infusion Solution Bag
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity
Clinical Observation of Implementing the MedGem Into a Medical Specialty Practice
Due to common CVD diseases associated from obesity, medical providers are in a position to provide assistance. However, less than 10% of all patients receive any weight loss advice from physicians.
- Trial name
- NCT00489502
- Testing
- Brief Counseling, REE Assessment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Microlife
Diabetes Mellitus Type 2, Obesity
Local Measures to Prevent Diabetes in the Værnes Region.
This is a development project involving four different municipalities in Central Norway. The aim is to identify adults with overweight and with an increased risk of developing diabetes mellitus type 2, then to prevent the disease…
- Trial name
- VEND-RISK (NCT01135901)
- Testing
- Behavioural change programme
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Norwegian University of Science and Technology
Childhood Obesity
USDA Healthy Caregivers/Healthy Children: A Childhood Obesity Prevention Program
Background: Many unhealthy dietary and physical activity habits that foster the development of obesity are established by the age of five.
- Trial name
- HC2 (NCT01722032)
- Testing
- Childhood Obesity
- Volunteers
- 1,100 people
- Sponsor
- University of Miami
Cardiovascular Diseases, Hypertension
Dose-Response to Exercise in Women Aged 45-75 Years (DREW)
To investigate the effects of different amounts of exercise on both cardiorespiratory fitness and risk factors for cardiovascular disease in sedentary, overweight, mildly hypertensive, but healthy, postmenopausal women aged 45 to…
- Conditions
- Cardiovascular Diseases, Hypertension, Postmenopausal, Overweight or Obese
- Trial name
- DREW (NCT00011193)
- Testing
- Exercise
- Where
- 2 sites in United States
- Volunteers
- 464 people
- Sponsor
- Pennington Biomedical Research Center
Obesity
Effect of Resistance Training on Microvascular, Hemodynamic and Physical Parameters in Obese Adolescents
The purpose of this study is to investigate the effect os resistance training on microvascular reactivity, endothelial functions, inflammatory markers, blood pressure, heart rate, body composition and physical fitness in obese…
- Trial name
- NCT01692314
- Testing
- Resistance training
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
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