Clinical trials: Obesity, Overweight
Diabetes, Obesity
Influence of Bariatric Surgery on Serum Levels of 26RFa
The 26RFa was recently discovered in the hypothalamus. In rodents it seems to be related to glucose metabolism and obesity. However, no data exists in obese patients or in patients with diabetes.
- Trial name
- RFa-Ba-S (NCT01982019)
- Testing
- Meal test taking and hormones measure including 26RFa
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Rouen
Obesity
ENDOPLY System in Humans: a Pilot Study
Prospective, non-randomized study aimed at defining the initial pattern of gastric plication with the ENDOPLY System, and assess feasibility, ergonomics and safety of the device Prospective, single-centre, open label, consecutive…
- Trial name
- NCT06292728
- Testing
- ENDOPLY System
- Where
- Czechia
- Volunteers
- 10 people
- Sponsor
- ENDOPLY
Morbid Obesity
Glucose Homeostasis Pre and Post Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery: Roux-en-Y gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the clinical trial.
- Trial name
- RB (NCT00981500)
- Testing
- gastric bypass, gastric banding, sleeve gastrectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
PTSD, Overweight and Obesity
I MOVE!+UP: Piloting an Integrated Weight Management Program for Veterans With PTSD
This study seeks to test I MOVE!+UP, which integrates individual evidence-based psychotherapy for PTSD with behavioral weight management among Veterans with a Body Mass Index of at least 30 and meeting criteria for current PTSD.
- Trial name
- NCT05755100
- Testing
- I MOVE!+UP
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Puget Sound Health Care System
Healthy Newborn Infants
Resilience to Antibiotic-induced Obesogenic Microbiota: Discovering Mechanism of Microbiota Modulation
The aim is to study whether the microbiota of children who are exposed to antibiotics at birth could be modified by synbiotic supplement and thereby reduce the risk of obesity, chronic diseases and respiratory tract infections.
- Trial name
- ReCoverHealth (NCT06974994)
- Testing
- Synbiotic Supplement
- Where
- Finland
- Volunteers
- 125 people
- Sponsor
- Turku University Hospital
Prostate Cancer, Obesity
How Does Prostate Cancer Metastasize? Studying the Role of Secreted Packages (Exosomes) From Fat Tissue in Lean and Obese Patients
The investigators will be collecting prostate and fat tissue from participants undergoing radical prostatectomy to culture and study in the laboratory.
- Trial name
- EXOPRO (NCT04167722)
- Testing
- Robotic Radical Prostatectomy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Pregnancy, Overweight and Obesity
Pregnancy Exercise Mode Effect on Childhood Obesity
The overall objective of this proposal is to conduct a longitudinal prospective study of overweight/obese (OW/OB) pregnant women and their offspring to determine which prenatal exercise mode will have the greatest impact on…
- Trial name
- NCT04805502
- Testing
- Exercise Modes
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Morbid Obesity
Extended Pouch Roux-en-Y Gastric Bypass Study
Morbid obesity is an increasing medical problem in the western countries. It's related to comorbidities as diabetes mellitus, hypertension, OSAS, arthrosis and hypercholesterolemia.
- Trial name
- NCT02218957
- Testing
- Extended Pouch RYGB, Standard RYGB
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Rijnstate Hospital
Overweight or Obesity
Effect of Akkermansia Muciniphila Akk11 on Metabolic and Gut Health in Overweight and Obese Subjects
To assess the efficacy and safety of the use of probiotics as a food supplement compared to placebo in regulating body metabolism and gut microbiota in overweight or obese subjects.
- Trial name
- NCT06653101
- Testing
- Probiotic
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Obesity, Weight Loss
Auricular Acupressure Integrated With Mobile Device for Weight Reduction
Obesity is a common global health problem. A three-arm randomised waitlist-controlled feasibility trial is proposed. A total of 59 subjects (19-21 subjects per arm) will be recruited.
- Conditions
- Obesity, Weight Loss, Mobile Application, Ear Acupressure
- Trial name
- NCT03442712
- Testing
- Auricular acupressure plus smartphone App, Auricular acupressure
- Where
- Hong Kong
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Obesity, Leptin Deficiency
Effect of Triticum Aestivum on Appetite, Ghrelin, Leptin, Adiponectin Hormonal Axis in Patients With Obesity
Obesity represents one of the major health problems worldwide; it is clear that current approaches to address obesity are largely unsuccessful.
- Conditions
- Obesity, Leptin Deficiency, Ghrelin, Adiponectin
- Trial name
- NCT06496100
- Testing
- Triticum Aestivum
- Where
- Mexico
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Insulin Resistance, Obesity
Studying Infant Nutrition and Blood Sugar
The purpose of this study is to learn about how breast milk from mothers with insulin-resistance may be different. Investigators are specifically studying insulin concentrations in breast milk.
- Trial name
- NCT03524469
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Obesity, Morbid, NASH
The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Ketosis and Ketoacidosis
Background: Ketosis after bariatric surgery is a metabolic process that occurs when the body breaks down fat for energy because of not getting enough carbohydrates.
- Conditions
- Obesity, Morbid, NASH, Ketosis, Keto Acidosis
- Trial name
- NCT06338969
- Testing
- Carbohydrate Restriction after a Gastric Bypass
- Where
- Kazakhstan
- Volunteers
- 150 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Atrial Fibrillation, Obesity and Obesity-related Medical Conditions
Metabolic Surgery for Atrial Fibrillation Elimination
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030.
- Trial name
- METSAFE (NCT07027969)
- Testing
- Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ali Aminian
Weight Loss, Obesity
A Trial to Test an Acceptance-based Therapy Program Among Adolescent Girls With Overweight/Obesity
The purpose of this study is to investigate the effects of an acceptance-based therapy weight loss intervention compared with enhanced care for adolescents.
- Conditions
- Weight Loss, Obesity, Overweight
- Trial name
- NCT04484831
- Testing
- ABT Weight Loss Intervention, Enhanced Care
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Florida
Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom
Chronic hypercapnic respiratory failure (CHRF) in the context of Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS) is associated with increased mortality.
- Conditions
- Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome (OHS), Nasal High Flow
- Trial name
- NCT05167201
- Testing
- Nasal High Flow
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Obesity and Diabetes Mellitus, Type 2
A Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Severely Obese Participants With Type 2 Diabetes Mellitus
The purpose of this study is to assess the effects of JNJ-64565111 compared with placebo in severely obese Type 2 Diabetes Mellitus (T2DM) participants after 12 weeks of treatment on: the percentage change in body weight from…
- Trial name
- NCT03586830
- Testing
- JNJ-64565111 Dose Level 1, JNJ-64565111 Dose Level 2, JNJ-64565111 Dose Level 3
- Where
- 27 sites in United States
- Volunteers
- 196 people
- Sponsor
- Janssen Research & Development, LLC
Overweight/Obesity, Metabolic Syndrome
Effects of Cranberry on Gut and Metabolic Health
The consumption of plant-based foods, particularly berries, has been associated with improved health due to their high content of bioactive compounds.
- Conditions
- Overweight/Obesity, Metabolic Syndrome, Insulin Resistance, Microbiota
- Trial name
- CRANOS (NCT07460856)
- Testing
- Cranberry beverage
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Laval University
Obesity
Family-based Outcome Results
Many obesity related risk factors are strikingly apparent in minority populations. Mexican-American children have the highest rates of overweight.
- Trial name
- NCT04132245
- Testing
- behavioral intervention, Obesity prevention intervention trial
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Obesity
Targeting Obesity With the Probiotic Lactiplantibacillus Plantarum IMC 510 (PRO-Weight-Control Study)
In recent decades, the prevalence of obesity has reached epidemic proportions, with the number of overweight or obese individuals continuing to increase worldwide.
- Trial name
- NCT05358301
- Testing
- Probiotic
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
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