Clinical trials: Obesity, Overweight
Obesity, Overweight
A Dose-Range Study of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity
Phase 2 clinical study will evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of various aleniglipron (GSBR-1290) dose regimens compared with placebo in participants living with obesity or overweight with ≥ 1…
- Conditions
- Obesity, Overweight, Chronic Weight Management
- Trial name
- ACCESS II (NCT06703021)
- Where
- 10 sites in United States
- Volunteers
- 85 people
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
ARDS, Human, Obesity, Morbid
Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
The goal of this clinical trial is to test a personalized intervention aiming to optimize the mechanical ventilator settings in morbidly obese patients suffering from moderate to severe Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- TGV-MOA (NCT06119516)
- Testing
- Esophageal pressure-guided strategy,
- Where
- 5 sites in France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy, Overweight
Nutrition Intervention for the Promotion of Healthy Weight Gain During Pregnancy
The purpose of this study is to determine if twice monthly interaction with a registered dietitian from 6-16 weeks gestation through 6 months postpartum will help women who are overweight or obese gain weight during pregnancy…
- Conditions
- Pregnancy, Overweight, Obesity
- Trial name
- NCT01056406
- Testing
- Nutrition Education
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Overweight
Barriers to Effective Weight Loss in Overweight Adolescents
The current study aims to investigate the impact of a comprehensive, team-based, family-centered, lifestyle modification program on body weight, metabolic abnormalities, fitness measures, and self-esteem in overweight adolescents…
- Trial name
- TEENS (NCT00562263)
- Testing
- Lifestyle modification
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Obesity
The Leisure-time Activity and Nutrition Program
The purpose of this investigation is to conduct an 8-week pilot study to examine the effects of two different leisure-time activity prescriptions on dietary intake, leisure-time activities, and weight loss in 30 adults receiving…
- Trial name
- LEAN (NCT01142206)
- Testing
- Dietary, Physical Activity, TV Watching + Physical Activity
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Obesity, Binge Eating Disorder
Binge Eating Self-help Treatment for University Students
BEST4US compares the effectiveness of two forms of self-help interventions that target college students, ages 18 years to 22 years, who report binge eating.
- Trial name
- BEST4US (NCT01888406)
- Testing
- Guided Self-Help, Pure Self-Help
- Where
- 2 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Francine Rosselli
Food Selection
Evaluating the Effectiveness of Within Versus Across-Category Front-of-Package Lower-Calorie Labelling on Food Demand
The important role that diet plays in health and disease is well established, as is its association with rising rates of obesity-a phenomenon of increasing concern in Singapore.
- Trial name
- NCT04165447
- Testing
- Front-of-pack labeling strategy
- Where
- Singapore
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Obesity
Reducing Health Disparities in Childhood Obesity
In this study, we will address cost barriers to participating in summer programs and hypothesize this will lead to marked improvements in children's obesogenic behaviors and a reduction in excessive, unhealthy weight gain over…
- Trial name
- NCT04072549
- Testing
- Free Summer Programming
- Where
- 2 sites in United States
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Obesity
The Irisin and Metabolic Exercise Training Study
It has been established that greater amounts of vigorous intensity physical activity lead to improved health outcomes. Interestingly, the response of biologically active substances, called myokines, differs according to exercise…
- Trial name
- iMET (NCT03514238)
- Testing
- High Intensity Interval Aerobic Exercise (HIIT), Continuous Moderate Aerobic Exercise (MOD), Control Sitting Condition (C)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Type 2 Diabetes Mellitus, Obesity
Effect of Gastric Bypass Surgery on Diabetes Status and Microvascular Complications in Obese Type 2 Diabetic Patients
This study evaluates the long-term benefits of Roux-en-Y gastric bypass (RYGB) on type 2 diabetes mellitus, focussing on the prevalence and predictors of T2DM improvement and remission after RYGB, and subsequently relapse of type…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Diabetic Retinopathy, Diabetic Nephropathy
- Trial name
- NCT02625649
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- University of Aarhus
Sleep, Sleep Apnea
Research Framework Exploring Sleep Health
This is a digital health study in which participants are recruited to collect sleep and activity data from digital activity trackers.
- Conditions
- Sleep, Sleep Apnea, Obesity, Mood
- Trial name
- REFRESH (NCT05197738)
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Overweight/Obesity
Snacking Effects on the Brain Response to Foods and Satiety During Dieting
This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.
- Trial name
- NCT07428187
- Testing
- Snack Type 1: Walnuts, Snack Type 2: Pretzels
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Obesity, Overweight
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
Study ASC30-301 (AURORA-1) is a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study to investigate the long-term efficacy, safety, and tolerability of three maintenance doses of once-daily oral…
- Conditions
- Obesity, Overweight, Chronic Weight Management
- Trial name
- AURORA-1 (NCT07743463)
- Testing
- ASC30 tablets A1
- Where
- 122 sites in United States, Canada and 5 more
- Volunteers
- 3,003 people
- Sponsor
- Ascletis Pharma (China) Co., Limited
Overweight and Obesity, Overweight
Piloting a Reinforcement Learning Tool for Individually Tailoring Just-in-time Adaptive Interventions
The purpose of this pilot study is to conduct a 12-week pilot feasibility study testing usability of a reinforcement learning model (AdaptRL) in a weight loss intervention (ADAPT study).
- Conditions
- Overweight and Obesity, Overweight, Obesity
- Trial name
- NCT05751993
- Testing
- ADAPT
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Overweight, Memory Disorder
Translation of Obesity and Cognitive Program by Lay Health Educators
Obesity is a major public health problem among older adults, with 31% of non-institutionalized older persons (60 years+) in the US obese and projections indicating that this will rise to 40% by 2010.
- Trial name
- Coaches (NCT01377506)
- Testing
- lifestyle counseling, Cognitive Training
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Non-alcoholic Steatohepatitis (NASH)
A Study to Assess Safety, Tolerability, PK and PD of AZD2693 in Non-alcoholic Steatohepatitis Patients
This study is intended to investigate the safety and tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD2693, following subcutaneous (SC) administration of multiple ascending doses in participants with…
- Trial name
- NCT04483947
- Testing
- AZD2693
- Where
- 16 sites in United States
- Volunteers
- 74 people
- Sponsor
- AstraZeneca
Sarcopenic Obesity, Obesity
Molecular Mechanisms Underpinning Sarcopenic Obesity
The coexistence of obesity and sarcopenia results in sarcopenic obesity, a high-risk geriatric condition associated with metabolic perturbations and several co-morbidities.
- Conditions
- Sarcopenic Obesity, Obesity, Sarcopenia, Aging
- Trial name
- NCT06120647
- Testing
- Essential amino acids (EAA)
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- The Swedish School of Sport and Health Sciences
Healthy, Overweight and Obesity
Effect of Acute Intake of Meals Containing Higher vs. Lower Energy From Protein on DIT
The objective of this trial is to assess the effects of acute intake of mixed meals containing higher vs. lower energy from protein on diet induced thermogenesis (DIT) in adults with overweight or obesity.
- Trial name
- NCT06494449
- Testing
- Higher protein, Lower protein
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Childhood Overweight
Effects of Lifestyle Intervention on Childhood Outcomes in LGA Infants
Large-for-gestational-age (LGA) infants have a higher risk of metabolic disease later in life, and their postnatal growth in early childhood may be associated with long-term adverse outcomes.
- Trial name
- NCT04661449
- Testing
- Comprehensive lifestyle intervention
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Childhood Obesity
Effectiveness of an IMB-based Intervention for Reducing Sweetened Beverages Consumption in Preschool Children
Sugar-sweetened beverages and over consumption of 100% fruit juice add unneeded calories to the diets of children, potentially leading to overweight.
- Trial name
- NCT03957148
- Testing
- Sugar-sweetened beverage reduction education for preschool children
- Where
- United States
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- UConn Health
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