Clinical trials: Obesity, Prediabetes
Overweight or Obesity, Pregnancy
DPP Feasibility Study of Breastfeeding - eMOMS 2.0
The purpose of this study is to investigate the impact of a comprehensive intervention that combines breastfeeding support with a diabetes prevention-based program (DPP) on postpartum weight retention and lactation duration among…
- Trial name
- NCT06372860
- Testing
- Diabetes Prevention Program, Breastfeeding, Usual Care
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Kansas Medical Center
PreDiabetes, Overweight and Obesity
Social Determinants and a Diabetes Prevention Program Tailored for African Americans
African Americans (AAs) have rates of diabetes mellitus (DM) twice that of Whites and are disproportionately affected by leading risk factors for DM - obesity and low-income.
- Trial name
- FIT4ALL (NCT05301413)
- Testing
- Culturally Tailored Diabetes Prevention Program, Culturally Tailored DPP Enhanced with Socioeconomic Supports, Diabetes Prevention Program
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Type 2 Diabetes
Application and Effectiveness Analysis of Internet-based Diabetes Prevention Program
This study was conducted to test the possibility of preventing or delaying the development of type 2 diabetes in individuals with impaired glucose tolerance and elevated fasting plasma glucose concentrations by internet-based…
- Trial name
- NCT01085682
- Testing
- Lifestyle counseling, Standard care
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Diabetes Mellitus, Type 2, PreDiabetes
Continuous Glucose Monitoring in Diabetes and Prediabetes
Evaluate the use of brief serial real time continuous monitoring (RT-CGM) as a behavior modification tool in obese patients with prediabetes and diabetes.
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Obesity
- Trial name
- NCT03805412
- Testing
- DEXCOM G6 RT-CGM
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Nicole Ehrhardt, MD
Diabetes, Pre-diabetes
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.
The objective of this clinical trial is to explore whether L-arginine supplementation with 3.32g/day may enhance antioxidant defenses in overweight and obese patients with pre-diabetes and metabolic syndrome, possibly providing…
- Conditions
- Diabetes, Pre-diabetes, Metabolic Syndrome
- Trial name
- L-BIOARG (NCT06686069)
- Testing
- bioarginina zero
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Federico II University
GDM, Insulin Resistance
In Vitro Fertilization Impact on Metabolic Parameters
A quantitative prospective cohort study will be conducted, where blood samples will be collected at different timings during the IVF protocol, to assess the impact of fertility medications on metabolic parameters of patients…
- Conditions
- GDM, Insulin Resistance, Glucose Intolerance, PCOS
- Trial name
- IVF (NCT03426228)
- Testing
- HbA1C
- Where
- United Arab Emirates
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Obesity, Overweight
The Influence of Physical Activity on the Gut Microbiome of Pre-Diabetic Adults
The present study is a 100-participant randomized controlled 2-arm parallel trial that employs a metagenomic approach to examine how 8 weeks of supervised moderate-intensity treadmill walking exercise (MWE) for 30-45 min 3…
- Conditions
- Obesity, Overweight, Overweight and Obesity, PreDiabetes
- Trial name
- NCT04931836
- Testing
- Physical Activity Intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Minnesota
Overweight and Obesity, PreDiabetes
The Effect of Appethyl® vs Placebo on Human Health (Appethyl)
The study will be conducted as a 26-week double-blinded randomized placebo-controlled trial of Appethyl® vs placebo in 100 overweight/obese (BMI ≥25.0-35.9 kg/m^2) men and women between 18-65 years with prediabetes (fasting…
- Trial name
- NCT05095038
- Testing
- Appethyl®
- Where
- Denmark
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Overweight, Pregnancy
A Low Glycemic Load Diet During Pregnancy in Overweight Women
This study will compare the effects of a low glycemic load versus standard diet for pregnancy on outcomes related to risk for obesity, diabetes, and heart disease in both mother and infant.
- Trial name
- NCT00364403
- Testing
- Low glycemic load, Low fat diet
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Type 2 Diabetes, PreDiabetes
Butyrate-enriched Triglyceride and Diabetes Prevention
A body of animal studies as well as observational studies in humans demonstrated that butyrate is one SCFA that has pronounced positive effects on body weight control, inflammation, and insulin resistance.
- Conditions
- Type 2 Diabetes, PreDiabetes, Obesity
- Trial name
- NCT06384313
- Testing
- butyrate/hexanoate-enriched triglycerides
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Metabolic Syndrome
Time Restricted Feeding to Reduce Weight and Cardiometabolic Risk
The obesity rate in Malaysia is higher than the average world obesity rate. Central obesity is a component of metabolic syndrome (MetS) which is also made up of dyslipidemia, impaired glucose tolerance, and hypertension.
- Conditions
- Obesity, Metabolic Syndrome, Pre Diabetes
- Trial name
- NCT04243746
- Testing
- Time Restricted Feeding, Standard Care
- Where
- Malaysia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- RCSI & UCD Malaysia Campus
Prediabetes, Obesity
The Effect of Hypocaloric Diet Associated With tDCS on Weight Loss and Metabolic Profile
To compare four weeks of transcranial direct current stimulation (tDCS) versus placebo associated with a reduced caloric diet on weight loss, glycemic control and regulators of hunger and satiety in overweight or obese subjects…
- Conditions
- Prediabetes, Obesity, Weight Loss, Diabetes
- Trial name
- NCT02683902
- Testing
- Active tDCS, Hypocaloric diet
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Prediabetes
Effects of Coffee Consumption on Metabolic Markers in Adults With Prediabetes and Obesity
Epidemiological studies have shown an inverse association between coffee consumption and risk of type 2 diabetes. However, the randomized controlled trials in prediabetes are limited to evaluate the effects of coffee.
- Trial name
- NCT06330727
- Testing
- Coffee capsule, Corn starch capsule
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Metabolic Syndrome, Overweight
Effects of Lignan-rich Diet on Cardiometabolic Risk Factors
Diet plays an important role in relation to prevention of type 2 diabetes, cardiovascular disease and certain cancers. Studies have shown that diets with high whole-grain content could decrease the risk of these lifestyle related…
- Conditions
- Metabolic Syndrome, Overweight, Central Obesity, Impaired Glucose Tolerance
- Trial name
- NCT02987595
- Testing
- Whole-grain rye, high lignan, Whole-grain wheat, low lignan
- Where
- Sweden
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Swedish University of Agricultural Sciences
PreDiabetes, Obesity
Intermittent Eating on Glucose Homeostasis in Prediabetes
Prediabetes is a high-risk state for diabetes development, lifestyle modification is the cornerstone of diabetes prevention. Two novel types of intermittent fasting recently have received more attention: the 5:2 diet and…
- Trial name
- NCT05717387
- Testing
- Time-restricted eating, The 5:2 diet
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Prediabetes, Type 2 Diabetes
Effect of Totum-63, Active Ingredient of Valedia, on Glucose and Lipid Homeostasis on Subjects With Prediabetes
Given the data on the active ingredients of Totum-63, this research aims to evaluate the effect of its chronic consumption (24 weeks) on glucose and lipid homeostasis and especially on fasting plasma glucose in volunteers with…
- Conditions
- Prediabetes, Type 2 Diabetes, Hypertriglyceridemia, Obesity
- Trial name
- TOTUM-63 TWO (NCT02868177)
- Testing
- Totum-63
- Where
- 6 sites in France, Ireland and 2 more
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Diabetes, Pre Diabetes
Jockey Club Precision Prevention Programme on Young Onset Diabetes
This is a community-based implementation program consisting of multiple components delivered by a multidisciplinary team to detect and prevent young onset diabetes with precision and value using biogenetic markers, digital tools…
- Conditions
- Diabetes, Pre Diabetes, Hypertension, Dyslipidemia
- Trial name
- NCT06693934
- Testing
- Risk assessment with biogenetic and clinical test to predict diabetes risk, Oral glucose tolerance test (OGTT) and cardiovascular-kidney-metabolic (CKM) risk factors, Medication
- Where
- Hong Kong
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Juliana CN Chan
Obesity, Prediabetes
ADRB3 Signaling Pathway in Human Adipose Tissue
This study will examine the gene expression of the adrenergic Beta-3 receptor (ADRB3) regulation in human subcutaneous adipose tissue before and after treatment with mirabegron, an ADRB3 agonist.
- Trial name
- NCT05634174
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Continuous Glucose Monitoring, Prediabetic State
Effect of Real-time Continuous Glucose Monitoring System in Overweight or Obese Adults With Prediabetes
In Korea, 5 million adults aged 30 years or older have diabetes. The development and expansion of Korea's economy and society, has led to dramatic chances in people's lifestyle and diet habits, and an increase in life expectancy.
- Conditions
- Continuous Glucose Monitoring, Prediabetic State, Obesity
- Trial name
- NCT04099550
- Testing
- RT-CGM, SMBG
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Overweight, Obesity
Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study)
Type 2 diabetes and prediabetes, which are mainly caused by a lack of physical activity and excess weight, put people at an increased risk of cardiovascular disease.
- Conditions
- Overweight, Obesity, Type 2 Diabetes, Prediabetes
- Trial name
- SHAPE3 (NCT00928005)
- Testing
- Weight loss diet, Weight loss diet plus exercise
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University