Clinical trials: Obesity, Prediabetes
Obesity, Overweight
Smart Technology for Weight Loss and Metabolic Health
The study will evaluate whether a technology-based lifestyle intervention program using primarily a smartphone platform is an acceptable and effective way for treating obesity.
- Conditions
- Obesity, Overweight, Prediabetes, Weight Loss
- Trial name
- NCT02742662
- Testing
- Wearable technology, smartscale, Smartphone applications, Standard Weight Management Visits
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Temple University
Prediabetes, Insulin Resistance
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity
This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.
- Conditions
- Prediabetes, Insulin Resistance, Overweight/Obesity
- Trial name
- MOTS-MET (NCT07505745)
- Testing
- MOTS-c (MDP), Route Subcutaneous injection, Regimen
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hudson Biotech
Pregnancy, Overweight and Obesity
Diabetes Prevention Program Feasibility Study of Breastfeeding
The purpose of this study is to learn about the impact of the Diabetes Prevention Program (DPP) coupled with intensive breastfeeding support to help overweight or obese pregnant women lose weight postpartum, improve their blood…
- Trial name
- NCT04021602
- Testing
- Diabetes Prevention Program, Breastfeeding Education, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Kansas Medical Center
Body Weight, Obesity
Meta-analysis of the Nordic Dietary Pattern on Cardiometabolic Risk and Cardiovascular Outcomes
The Nordic Diet is a dietary pattern rich in traditional Nordic foods, including berries, grains, and fatty fish common in northern Europe.
- Conditions
- Body Weight, Obesity, Overweight and Obesity, Obesity, Abdominal
- Trial name
- NCT04094194
- Testing
- Nordic diet
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Impaired Glucose Tolerance, Overweight
Acupuncture for Impaired Glucose Tolerance in Overweight/Obese Population
This is a prospective, multicenter, parallel-group, participants- and assessors-blinded randomized trial aiming to evaluate the effectiveness and safety of acupuncture in improving glucose metabolism for overweight/obese…
- Conditions
- Impaired Glucose Tolerance, Overweight, Obese, Prediabetic State
- Trial name
- NCT05347030
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Yan Yan
PreDiabetes, Obesity
Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes
Purpose of the Study: This study is to learn more about how exercising at different times of the day (morning versus evening) affects metabolism of glucose in the body, sleep, activity outside of exercise, and other factors.
- Conditions
- PreDiabetes, Obesity, Inactivity/Low Levels of Exercise
- Trial name
- TExIS (NCT06292000)
- Testing
- AM Exercise, PM Exercise
- Where
- United States
- Sponsor
- University of Colorado, Denver
Pre-diabetes, Overweight and Obesity
A Personalized Diet Study to Reduce Glycemic Exposure
The aim of this 2-phase, randomized clinical trial will be to examine the effects of two behavioral weight loss interventions on weight loss.
- Trial name
- NCT03336411
- Testing
- mHealth, Personalized mHealth
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Overweight and Obesity, Pre Diabetes
Time Restricted EATing (TREAT) Pilot Study
The TREAT Pilot is a 3 months open-label pilot study to examine the effect of restricting the duration of eating (Time Restricted EATing) in metabolically unhealthy adults with overweight or obesity.
- Trial name
- NCT03956290
- Testing
- TREAT pilot intervention
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Columbia University
Prediabetes, Diabetes
Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food
This pilot study aims to explore the potential benefits of consuming Greek bottarga (grey mullet fish roe) in individuals with at least one metabolic abnormality (low HDL cholesterol, high LDL cholesterol, high triglycerides…
- Conditions
- Prediabetes, Diabetes, High Cholesterol/Hyperlipidemia, Obesity & Overweight
- Trial name
- NCT06988462
- Testing
- Bottarga, Comparator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cambridge Health Alliance
Pre Diabetes, Overweight and Obesity
A Digital Therapy for Diabetes Prevention Among Overweight Adults in Terengganu, Malaysia
The modern world revolves around technology; unsurprisingly companies are leveraging the expertise of the digital tech industry to aid in the prevention of chronic diseases.
- Trial name
- NCT03997656
- Testing
- MyDiPP (Malaysia Diabetes Prevention Program), usual care
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Sultan Zainal Abidin
Pre-diabetes, Obesity
Healthy Living Partnerships to Prevent Diabetes in Veterans Pilot Study
Diabetes and obesity are both major public health concerns and the prevalence of diabetes is even higher in the patient population of the Veterans Administration.
- Trial name
- HELP Vets (NCT02835495)
- Testing
- HELP Vets Intervention, Individual Education Program
- Where
- 2 sites in United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Metabolic Syndrome
A Study to Explore the PK and PD of INV-202 in Metabolic Syndrome
INV-202-CL-105 is a phase 1B study to examine the safety and tolerability, as well as the pharmacokinetics (PK) pharmacodynamic (PD) effects of INV-202 in subjects with metabolic syndrome over 28 days.
- Trial name
- NCT05282446
- Testing
- INV-202
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Inversago Pharma Inc.
Diabetes, Obesity
Role of Methane in Glycemic Control
The purpose of this study is to determine how certain types of bacteria in the human gut may affect weight gain, and contribute to the development of diabetes.
- Trial name
- NCT01638429
- Testing
- Neomycin, Rifaximin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Impaired Glucose Tolerance, Type2 Diabetes
Influence of Preprandial Metformin Administration on Carbohydrate Absorption
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.
- Trial name
- METTIME (NCT04018105)
- Testing
- Oral glucose tolerance test (OGTT) with or without metformin
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Adipose Tissue, Brown, Brown Adipose Tissue
Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT).
This study investigates repetitive cold-water exposure on brown fat activity assessed by PET/CT scanning. Furthermore we will assess glucose control upon winter-swimming.
- Conditions
- Adipose Tissue, Brown, Brown Adipose Tissue, Uncoupling Protein 1, Cold Exposure
- Trial name
- WinterBAT (NCT03541096)
- Testing
- Winter Swimming, Control group
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Kristian Karstoft
Obesity, Prediabetic State
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.
The study aims to investigate the effects of oral inositols on insulin-resistance and metabolic variables (triglycerides, total cholesterol, HDL cholesterol) in children aged 8-12 years with obesity and insulin-resistance.
- Conditions
- Obesity, Prediabetic State, Dyslipidemias, Insulin Resistance
- Trial name
- ONIRICO (NCT05701813)
- Testing
- INOSITOLS, CELLULOSE
- Volunteers
- 56 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pre-diabetes, Obesity
Sub-Study of the PREVIEW Study Australia
The aim of this study is to investigate possible enduring effects of a standard 2-month weight loss program on appetite regulation, bone homeostasis and muscle strength in younger and older adults, as well as the impact of…
- Trial name
- NCT02030249
- Testing
- Low calorie diet administered from 0 to 2 months, High Protein / Low Glycaemic Index, Moderate Protein / High Glycaemic Index
- Where
- 3 sites in Australia
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Metabolic Syndrome
Dose Ranging Study of the Effects of Alpha Lipoic Acid on Oxidative Stress
Heart disease is the most common cause of death in the United States and it is commonly found in people with diabetes and high cholesterol.
- Trial name
- Alpha (NCT00857376)
- Volunteers
- 77 people
- Sponsor
- Johns Hopkins University
Pre-diabetes
Preventing Diabetes in the Deep South: Extending Partnerships and Adapting Interventions to Reach Rural Communities at High Risk.
Diabetes is responsible for a huge and growing burden of patient suffering and social costs, and the impact of this disease is shared disproportionately by minorities and in rural resource-challenged communities, particularly in…
- Trial name
- NCT04343872
- Testing
- Receive lifestyle modification alone, Metformin therapy
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
PreDiabetes, Adolescent Obesity
SMART GOALS for Youth With Prediabetes
The goal of this study is to compare the impact of a SMART ((specific, measurable, attainable, realistic, or timely) Goal setting protocol on body weight, metabolic parameters (Hemoglobin A1c, lipids), diet quality and physical…
- Conditions
- PreDiabetes, Adolescent Obesity, Behavior, Health, Nutritional and Metabolic Diseases
- Trial name
- NCT06067451
- Testing
- SMART GOALS Setting Tool/ Protocol
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Northwell Health