Clinical trials: Obesity, Prediabetes
Glucose Intolerance, Obesity
Clinical Trial to Assess the Effects of Candesartan on the Carbohydrate Metabolism of Obese Subjects
Hypothesis: The use of candesartan 16-32 mg/d for 6 months improves the carbohydrate metabolism, and decreases the plasmatic levels of adipocytokines and oxidative stress markers, in non diabetic, non hypertensive subjects with…
- Trial name
- ARAMIA (NCT00319202)
- Testing
- Candesartan
- Where
- Colombia
- Volunteers
- 56 people
- Sponsor
- Fundación Cardiovascular de Colombia
Diabetes, Obesity
A Study of the Function of Hormones Present In Taste Buds
The purpose of this study is to find out whether the hormones in the taste buds are affected by tasting and eating food, and also whether these hormone levels are affected by an increase in body weight or type 2 diabetes.
- Conditions
- Diabetes, Obesity, Pre-Diabetes, Metabolic Syndrome
- Trial name
- NCT00233298
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Obesity, Glucose Intolerance
Prevalence of Carbohydrate Intolerance in Lean and Obese Children
The prevalence of obesity in children is reaching epidemic proportions. Excess adiposity is more than just a cosmetic problem, having substantial metabolic consequences.
- Conditions
- Obesity, Glucose Intolerance, Diabetes, Acanthosis Nigricans
- Trial name
- NCT00000112
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Sleep Apnea, PreDiabetes
Technology-Supported Treatment of Sleep Apnea in Prediabetes
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular…
- Conditions
- Sleep Apnea, PreDiabetes, Overweight or Obesity
- Trial name
- TECH (NCT04225507)
- Testing
- Diet and exercise coaching, CPAP Treatment
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Chicago
Obesity, Prehypertension
Weight Inclusive and Adaptive Strategies to Enhance Cardiometabolic Health in Black Adults
The proposed 6-month pilot Sequential Multiple Assignment Randomize Trial (SMART) has two aims. The first and primary aim is to determine the feasibility of conducting a full-scale SMART to compare weight-focused (i.e., weight…
- Conditions
- Obesity, Prehypertension, Hypertension, PreDiabetes
- Trial name
- WISE Health (NCT06284681)
- Testing
- Weight-focused health coaching, Weight-neutral health coaching, Intensify lifestyle approach
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Alabama at Birmingham
Pre-diabetes, Overweight and Obesity
A Personalized Diet Study to Reduce Glycemic Exposure
The aim of this 2-phase, randomized clinical trial will be to examine the effects of two behavioral weight loss interventions on weight loss.
- Trial name
- NCT03336411
- Testing
- mHealth, Personalized mHealth
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Insulin Resistance, Abdominal Obesity
Pilot Study With GFT505 (80mg) in Patients With Insulin Resistance and Abdominal Obesity
The purpose of this study is to demonstrate the efficacy on insulin sensitivity of GFT505 at 80mg/d in male patients with insulin resistance and abdominal obesity. Evaluation will be made using a glucose clamp technique.
- Trial name
- NCT01271777
- Testing
- GFT505 80mg
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- Genfit
Obesity, Overweight
Hybridized Three Steps Intervention to Prevent Diabetes in Venezuela
The American Diabetes Association recommends implementing the Diabetes Prevention Program (DPP) in subjects with prediabetes. In the DPP, weight reduction was the main predictor of a lower incidence of type 2 diabetes (T2D), each…
- Conditions
- Obesity, Overweight, PreDiabetes, Diabetes Mellitus, Type 2
- Trial name
- HITS (NCT04927871)
- Testing
- Total Diet Replacement (TDR), Medical Nutritional Therapy (MNT), Diabetes Prevention Program 4 months
- Where
- 2 sites in Venezuela
- Volunteers
- 156 people
- Sponsor
- Foundation for Public Health and Epidemiological Research of Venezuela
PreDiabetes, Obesity
Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes
Purpose of the Study: This study is to learn more about how exercising at different times of the day (morning versus evening) affects metabolism of glucose in the body, sleep, activity outside of exercise, and other factors.
- Conditions
- PreDiabetes, Obesity, Inactivity/Low Levels of Exercise
- Trial name
- TExIS (NCT06292000)
- Testing
- AM Exercise, PM Exercise
- Where
- United States
- Sponsor
- University of Colorado, Denver
Insulin Sensitivity, Glucose Intolerance
The Effects of Sea Buckthorn and Strawberry on Postprandial Glycaemia, Insulinemia and Appetite
The effects of strawberry and sea buckthorn on postprandial glycaemia and insulinemia as well as on metabolic profiles were examined in overweight or obese male subjects.
- Trial name
- OPUS-WP3C (NCT02412995)
- Testing
- Meal sequence 1-2-3, Meal sequence 1-3-2, Meal sequence 2-3-1
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Prediabetic State, Overweight
Glucose Metabolism Effects of Vitamin D Supplementation in Prediabetes
Vitamin D deficiency is widespread throughout the world, and the deficiency has been associated with several chronic diseases, such as cardiovascular diseases and diabetes.
- Conditions
- Prediabetic State, Overweight, Obese
- Trial name
- VitDmet (NCT01479933)
- Testing
- Vitamin D3, Vitamin D 80
- Where
- Finland
- Volunteers
- 73 people
- Sponsor
- University of Eastern Finland
Overweight/Obesity, Prediabetes
Mobile Internet Healthcare and Three Disciplines Co-management Intervention for Overweight/Obese Prediabetic Patients
Diabetes mellitus is a chronic metabolic disease associated with a high rate of disability and mortality. Prediabetes is the intermediate stage from normal blood glucose to diabetes.
- Conditions
- Overweight/Obesity, Prediabetes, Weight Management
- Trial name
- NCT06147752
- Testing
- mobile internet healthcare and "co-management of three disciplines"
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Obesity, PreDiabetes
Reducing Cardiometabolic Risk and Promoting Functional Health in Older Adults With Obesity and Prediabetes
Obesity and pre-diabetes threatens the overall health and functional independence of older adults but lifestyle weight management for diabetes prevention, soon to be reimbursed by Medicare, can reduce this burden.
- Conditions
- Obesity, PreDiabetes, Aging
- Trial name
- Sustain-DPP (NCT03500640)
- Testing
- DPP Intensive: 30-minute calls, DPP Support: 15-minute calls
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Obesity, PreDiabetes
Network Meta-analysis of Intermittent Fasting and Cardiometabolic Risk
Intermittent fasting is a method of restricting calories over a defined period of time and includes regimens such as whole-day fasting, alternate-day fasting, and time-restricted feeding.
- Conditions
- Obesity, PreDiabetes, Diabetes, Hypertension
- Trial name
- NCT05309057
- Testing
- Intermittent Fasting
- Where
- 2 sites in Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Overweight, Obesity
PROTeIn-rich Meals to Control Glucose
The overall aim is to identify the dietary pattern for prevention and treatment of type 2 diabetes. The specific aim of this pilot project is to compare effects of two diets with different diurnal distribution of carbohydrates…
- Conditions
- Overweight, Obesity, Prediabetes, Type 2 Diabetes
- Trial name
- PROTIME (NCT06382480)
- Testing
- Diet with specific macronutrient composition.
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- German Institute of Human Nutrition
Arterial Stiffness, Dietary Modification
Egg Protein Hydrolysate and Vascular Function
The incidence of type 2 diabetes mellitus (T2DM) is rapidly growing. Patients with T2DM are at increased risk of developing long term micro- and macrovascular complications.
- Conditions
- Arterial Stiffness, Dietary Modification, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT01559896
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Impaired Glucose Tolerance, Abdominal Obesity
Pilot Study With GFT505 (80mg) in Patients Presenting With Impaired Glucose Tolerance and Abdominal Obesity.
The purpose of this study is to evaluate the efficacy of GFT505 80mg compared with placebo in improving Oral Glucose Tolerance Test (OGTT), in patients with impaired glucose tolerance and abdominal obesity, and to assess the…
- Trial name
- NCT01275469
- Testing
- GFT505 80mg
- Where
- 20 sites in France
- Volunteers
- 47 people
- Sponsor
- Genfit
PreDiabetes, Adolescent Obesity
SMART GOALS for Youth With Prediabetes
The goal of this study is to compare the impact of a SMART ((specific, measurable, attainable, realistic, or timely) Goal setting protocol on body weight, metabolic parameters (Hemoglobin A1c, lipids), diet quality and physical…
- Conditions
- PreDiabetes, Adolescent Obesity, Behavior, Health, Nutritional and Metabolic Diseases
- Trial name
- NCT06067451
- Testing
- SMART GOALS Setting Tool/ Protocol
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Northwell Health
Overweight or Obesity, Prediabetes or Diabetes
Remotely Delivered Resistance Training for Cardiometabolic Health Among Black Women
The purpose of this study is to collect preliminary data on the feasibility, acceptability, and potential effects of a novel, remotely delivered resistance training program.
- Conditions
- Overweight or Obesity, Prediabetes or Diabetes, Prehypertension (Elevated Blood Pressure) or Hypertension, Resistance Training
- Trial name
- OVERCOME-IT (NCT06360536)
- Testing
- Resistance Training
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Alabama at Birmingham
Insulin Resistance, Obesity
Efficacy of Lyophilized Dried Cornus Mas L. on Anthropometric and Biochemical Parameters in Insulin Resistance
The aim of this study is to determine the effect of 3 months supplementation of lyophilize dried cornelian cherry (Cornus mas L.) on women diagnosed with insulin resistance.
- Conditions
- Insulin Resistance, Obesity, PreDiabetes
- Trial name
- NCT05292300
- Testing
- Cornelian Cherry (Cornus mas L.), Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Marmara University