Clinical trials: Obesity, Prediabetes
Prediabetes, Obesity & Overweight
Human Pilot Study for the Investigation of the Role of Bilberry and Olive Bioactives on Oxidative Stress Parameters and Inflammatory Markers.
Numerous plant-based foods contain bioactive compounds, in particular polyphenols, which have antioxidant, anti-inflammatory, and metabolic regulatory effects.
- Conditions
- Prediabetes, Obesity & Overweight, Inflamation, Oxidative Stress
- Trial name
- BIOTRANSFORM (NCT07659028)
- Testing
- supplementation, food
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Obesity, Pre-diabetes
The Effect of Time-Restricted Eating in Cardiometabolic Health
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day.
- Trial name
- NCT04484987
- Testing
- 9 hours daily eating window, 15 hours daily eating window
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, Davis
Sedentary Behavior, Mild Cognitive Impairment
The DURATION Study: reDUcing sedentaRy behAviour to Maintain cogniTIve functiON.
Rationale: Older adults spend the majority of their time in sedentary behaviours (SB). High amounts of SB have been correlated with reduced cognitive performance.
- Conditions
- Sedentary Behavior, Mild Cognitive Impairment, Glucose Intolerance, Overweight and Obesity
- Trial name
- NCT04323423
- Testing
- interrupting sedentary behaviour with light physical activity
- Where
- Canada
- Sponsor
- Western University, Canada
Prediabetic State, Life Style
PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes
Nearly half of adults in the United States have or are at risk of developing type 2 diabetes. The overall goal of this community-engaged research is to examine the efficacy of an innovative couple-based lifestyle intervention to…
- Conditions
- Prediabetic State, Life Style, Intervention Study, Social Support
- Trial name
- PT2T (NCT06690788)
- Testing
- Individual intervention condition (PreventT2), Couple-based intervention condition (PreventT2 Together; couple-based adaptation of 2021 PreventT2; approved by the CDC in November 2022 as an Alternate Curriculum for use in the NDPP)
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- University of Utah
Type 2 Diabetes, Obesity, Prediabetes
The Influence of Glucose Flux on Fat Synthesis in a Whole Body Calorimeter
The study is carried out to find out the inclusion of high and low glycaemic index foods to daily meals and how they impact 24 hour blood glucose fluctuations and energy regulation.
- Trial name
- NCT02631083
- Testing
- Breakfast, lunch, snack and dinner
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)
The undercarboxylated fractions of the two vitamin K-dependent proteins osteocalcin and matrix Gla protein have been shown to play key roles in type 2 diabetes and cardiovascular disease (at least in mouse models).
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Prediabetes
- Trial name
- NCT01972113
- Testing
- Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Diabetes Mellitus, Type 2, Insulin Resistance
The Acute T-Rex (Timing of Resistance Exercise) Study
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Glucose Intolerance, Sleep Disturbance
- Trial name
- NCT06366399
- Testing
- Resistance Exercise Timing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Obesity, Diabetes
Studying the Effect of Capsinoids on Brown Fat Using Infrared Thermal Imaging.
The primary hypothesis of this study is that consumption of capsinoids increases brown adipose tissue activity, detectable by infrared thermal imaging.
- Conditions
- Obesity, Diabetes, Impaired Glucose Tolerance
- Trial name
- NCT01961674
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity, Prediabetic State
Physical Activity and Obesity
The purpose of the study is to see if a twelve-week exercise intervention in overweight or obese subjects with pre-diabetes or early disease course type 2 diabetes can lead to improved skeletal muscle capillary blood flow by…
- Conditions
- Obesity, Prediabetic State, Sedentary Lifestyle
- Trial name
- NCT02060240
- Testing
- High Activity
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Pre-diabetes, Overweight and Obesity
Timing Exercise Training as Strategy to Improve Insulin Sensitivity and Substrate Metabolism in Men and Woman With Pre-diabetes
n a retrospective analysis of an exercise training program performed either in the morning or afternoon, we found that the afternoon training group improved their peripheral insulin sensitivity and fasting plasma glucose levels…
- Trial name
- Timed Training (NCT06014684)
- Testing
- Timing of exercise
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity
Physical Activity Following Surgery Induced Weight Loss
The primary objective of this study will be to determine the effects of physical activity in patients during substantial surgery-induced weight loss.
- Trial name
- NCT00692367
- Testing
- Physical Activity
- Where
- 2 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Overweight and Obesity, PreDiabetes
Effects of Yogurt With Spirulina on Cardiometabolic Risk Markers
The effects of yogurt with spirulina consumption compared to conventional yogurt (without spirulina) on several cardiometabolic and anthropometric parameters in individuals at risk of cardiovascular disease
- Conditions
- Overweight and Obesity, PreDiabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06114563
- Testing
- Spirulina yogurt, Conventional yogurt
- Where
- Greece
- Volunteers
- 64 people
- Sponsor
- Agricultural University of Athens
Metabolic Syndrome, Diabetes Mellitus, Type 2
Induced and Controlled Dietary Ketosis as a Regulator of Obesity and Metabolic Syndrome Pathologies
Original research article entitled Induced and Controlled Dietary Ketosis as a Regulator of Obesity and Metabolic Syndrome by Madeline Gibas for consideration for publication in a clinical journal.
- Conditions
- Metabolic Syndrome, Diabetes Mellitus, Type 2, Pre Diabetes
- Trial name
- NCT03047447
- Testing
- Dietary Ketosis: Regulator of Obesity and Metabolic Syndrome
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristlecone Behavioral Health, Inc.
Overweight and Obesity, Diabetes Mellitus, Type 2
AI-Driven Metabolic Cohort in Overweight/Obese Chinese Adults
The goal of this observational cohort study is to delineate the five-year dynamic trajectories of metabolic phenotypes in Chinese adults with overweight or obesity, with or without type 2 diabetes, focusing on transition rates…
- Conditions
- Overweight and Obesity, Diabetes Mellitus, Type 2, Prediabetic State, Metabolic Syndrome
- Trial name
- COMET-AI (NCT07584330)
- Where
- China
- Volunteers
- 2,800 people
- Sponsor
- Zhujiang Hospital
Cardiovascular Diseases, Overweight
Enhancing Mental and Physical Health of Women Veterans
Women Veterans are the fastest growing segment of VA users. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able…
- Conditions
- Cardiovascular Diseases, Overweight, Obesity, Smoking
- Trial name
- EMPOWER (NCT05050266)
- Testing
- EBQI, REP
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Obesity, Type 2 Diabetes (T2D)
A Retrospective Real-World Cohort Study
The primary objectives are to determine the prevalence and overlap of major cardiometabolic diseases, identify multimorbidity clusters, and characterize demographic, clinical, laboratory, and treatment patterns across the cohort…
- Conditions
- Obesity, Type 2 Diabetes (T2D), Prediabetes, Cardiovascular Disease (CVD)
- Trial name
- SCALA-TK-CM (NCT07781371)
- Testing
- No treatment given
- Where
- Denmark
- Volunteers
- 100,000 people
- Sponsor
- Novo Nordisk A/S
Pediatric Obesity, Insulin Resistance
Study of Post-meal Blood Sugar Peaks in Association With Vascular Disease in Childhood Obesity
The main purpose of this study is to determine whether treatment with acarbose attenuates post-prandial glycemic excursions in non-diabetic/pre-diabetic obese children as determined by continuous glucose monitoring systems…
- Conditions
- Pediatric Obesity, Insulin Resistance, Impaired Glucose Tolerance, Cardiovascular Disease
- Trial name
- NCT00846521
- Testing
- Acarbose
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
PreDiabetes, Obesity
The Time-Restricted Intake of Meals Study
TRIM is a randomized, controlled feeding study to evaluate if eating earlier in the day vs. later in the day impacts weight and glucose homeostasis.
- Trial name
- TRIM (NCT03527368)
- Testing
- Time-restricted feeding, Usual feeding pattern
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pre Diabetes, Obesity
Study of the Food Order Behavioral Intervention in Prediabetes
Investigators have previously shown that eating carbohydrates after protein or vegetables resulted in reduced glucose and insulin excursions over 180 min in patients with T2DM and in individuals with prediabetes as well.
- Trial name
- NCT03896360
- Testing
- Food order behavioral intervention plus standard care, Standard Care
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Weill Medical College of Cornell University
Lifestyle-related Condition, Obesity
MyLife: A Digital Health Coaching Program
Lifestyle behaviors such as sleep, diet, and physical activity, are implicated in a number of chronic conditions including hypertension, obesity, diabetes, heart failure, and obstructive sleep apnea.
- Conditions
- Lifestyle-related Condition, Obesity, Sedentary Lifestyle, PreDiabetes
- Trial name
- NCT03529903
- Testing
- Health Coaching
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles