Clinical trials: Obesity/Overweight
Heart Diseases, Cardiovascular Diseases
Strong People Strength Training Study
The Strong People Strength Training study aims to assess whether a community-based progressive strength training program can improve risk factors for diabetes and heart disease in older rural adults.
- Conditions
- Heart Diseases, Cardiovascular Diseases, Diabetes, Sedentary Lifestyle
- Trial name
- NCT04203563
- Testing
- Strong People Strength Training
- Where
- 6 sites in United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Cornell University
Time Restricted Feeding, Obesity, Abdominal
Efficacy and Feasibility of Time-restricted Eating on Cardiometabolic Health in Adults With Overweight/Obesity
In Spain, obesity epidemic is one of the leading contributors of chronic disease and disability. Obesity is associated with higher morbidity and all-cause mortality risk especially when fat is stored in the abdominal area (i.e.…
- Conditions
- Time Restricted Feeding, Obesity, Abdominal, Cardiometabolic Syndrome
- Trial name
- EXTREME (NCT05310721)
- Testing
- Early time-restricted eating, Late time-restricted eating, Self-selected time-restricted eating
- Where
- 2 sites in Spain
- Volunteers
- 197 people
- Sponsor
- Universidad de Granada
Weight Gain, Obesity
Chromium Piccolinate in the Prevention of Weight Gain Induced by Serotonergic Medications Initiated on Psychiatric Inpatient Units.
A majority of patients who suffer from mental illness are treated with serotonin regulating FDA approved medications. Some of these medications also block histamine transmission, increase blood prolactin levels, induce insulin…
- Trial name
- NCT00759993
- Testing
- chromium piccolinate
- Volunteers
- 60 people
- Sponsor
- State University of New York - Upstate Medical University
Childhood Obesity, Overweight and Obesity
Childhood Obesity - Prevention of Diabetes Through Changed Eating Patterns
The main purpose of the present study is to perform a 10 weeks dietary intervention study with a follow-up for 52 weeks in children from 7-14 years of age with overweight or obesity.
- Conditions
- Childhood Obesity, Overweight and Obesity, Adolescent Obesity, Adolescent Overweight
- Trial name
- COPE (NCT04522921)
- Testing
- Diet with a higher amount of protein (25E% per day), Increased follow-up contact after the 10-week intervention, Diet with a lower amount of protein (15E% per day)
- Where
- 2 sites in Denmark
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Schizophrenia
Bariatric Surgery in Patients With Schizophrenia
It is known that schizophrenia is associated with obesity in a significant number of patients and it implies a poor prognostic factor, with weight loss being important in this population.
- Trial name
- SCHIZOBAR (NCT06043206)
- Testing
- Bariatric Surgery
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Diabetes, Obesity
Healthy Eating and Active Living Taught at Home
The purpose of this research study is to evaluate two different Parents as Teachers curriculums taught by parent educators, during home visits.
- Trial name
- HEALTH (NCT01567033)
- Testing
- PAT Curriculum + Health Information
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
The purpose of this study is to evaluate tirzepatide within a real-world setting to assess body weight loss and incidence of type 2 diabetes in adults without diabetes who have obesity and at least one weight-related comorbid…
- Trial name
- NCT07247084
- Testing
- Tirzepatide, Standard of Care
- Where
- 30 sites in United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 2
C-Reactive Protein (CRP) in Obese Diabetic Women
The purpose of this study is to determine whether treatment with rosuvastatin for 6 months in obese type 2 diabetic women will improve their lipid profiles and thus prevent the progression to cardiovascular disease.
- Trial name
- NCT00262548
- Testing
- Rosuvastatin; improvement of lipid profile
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Obesity, Diabetes
The Effects of Carbohydrate Source on Food Intake, Blood Glucose and Gut Hormone Response in Healthy Children
This study will compare the effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children.
- Trial name
- NCT02499107
- Testing
- Rice treatment, Pasta treatment, Boiled and mashed potato treatment
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes Mellitus
A Study to Investigate Different Doses of 0382 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.
A Phase 2 study with two cohorts of differing doses designed to evaluate the efficacy, safety and pharmacokinetics (PK) of MEDI0382 in patients with Type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT03244800
- Testing
- MEDI0382
- Where
- 5 sites in Germany
- Volunteers
- 65 people
- Sponsor
- MedImmune LLC
Incretin Action, Obesity
Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.
Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism.
- Trial name
- NCT01232244
- Testing
- GLP-1 infusion, Glucagon infusion, Oxyntomodulin infusion
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Obesity, Social Dominance
Subjective Social Status and Energy Balance
Investigators examined the associations between SSS, energy balance, food intake and changes in body composition following a high calorie lunch for 2 weeks.
- Conditions
- Obesity, Social Dominance, Social Behavior, Eating Behavior
- Trial name
- NCT03510364
- Testing
- Dietary intervention
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Cardiovascular Risk Factors
Cocoa Extract-enriched Meals and Cardiovascular Risk in Older Population
Obesity prevalence in elderly populations has increased in the last years, and the reduction of overweight and obesity is a priority target in populations of all age ranges worldwide.
- Trial name
- NCT01596309
- Testing
- Cocoa extract
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Healthy, Obesity
Mitochondrial Function in Circulating Cells and Muscle Tissue
The main goal of this project is to determine whether mitochondrial function in circulating cells is related to that measured in the muscle fibers of the same subjects.
- Conditions
- Healthy, Obesity, Insulin Sensitivity, Women
- Trial name
- MitoWomen (NCT02700698)
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Hypertension, Hypercholesterolemia
Effects of Purple Vegetables on Cardiovascular Disease (CVD) Risk Factors
The hypothesis is that richly coloured purple vegetables, rich in polyphenolic compounds including anthocyanins will have higher antioxidant and other biological activities, than more lightly coloured versions of these foods.
- Conditions
- Hypertension, Hypercholesterolemia, Type II Diabetes, Obesity
- Trial name
- NCT01564498
- Testing
- vegetable
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Guelph
Obesity, Physical Activity
Reducing Television Viewing To Prevent Obesity in Hispanic Preschool Children
Obesity has been linked to the development of multiple cancers, and to poorer prognoses and higher mortality rates for certain pediatric and adult cancers.
- Conditions
- Obesity, Physical Activity, Sedentary Activity, Television Viewing
- Trial name
- NCT01216306
- Testing
- Television reduction curriculum
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Obesity, Oxidative Stress
Investigations of Botanicals on Food Intake, Satiety, Weight Loss, and Oxidative Stress
Despite widespread efforts to improve the treatment of obesity, only limited progress has been made. Calorie restriction (CR) has consistently been shown to produce weight loss, as well as delay the onset of age-related diseases…
- Trial name
- NCT01238887
- Testing
- Garcinia cambogia-derived hydroxycitric acid (2800 mg/day), Garcinia Cambogia derived Hydroxycitric Acid
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Florida
Endometrial Cancer, Obesity
Tirzepatide in Obesity-Driven Endometrial Cancer
LCCC2415 examines the antiproliferative effect of tirzepatide on the endometrium of endometrial cancer (EC). This is a pre-operative window clinical study.
- Trial name
- NCT07065552
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Intubation;Difficult, Obesity, Morbid
Face-to-face Intubation in Morbidly Obese
Introduction : In a typical endotracheal intubation, the patient is in the supine position, with the anesthetist standing behind his head and with adequate access to the head and neck of the patient.
- Trial name
- NCT04959149
- Testing
- AirTraq videolaryngoscope
- Where
- Poland
- Volunteers
- 76 people
- Sponsor
- Medical University of Lodz
Acute Pancreatitis, Obesity
The Course of Acute Pancreatitis in Patients With Different BMI Groups
In obese (OB) patients, the presence of an increased inflammatory state in the body due to the increase in abdominal adipose tissue and increase in the frequency of gallstones and lipid levels are expected to increase the…
- Conditions
- Acute Pancreatitis, Obesity, Body Weight
- Trial name
- NCT04901949
- Where
- Turkey (Türkiye)
- Volunteers
- 1,334 people
- Sponsor
- Bezmialem Vakif University