Clinical trials: Obesity; Overweight
Obesity, Overweight
Just-in-time Adaptive Intervention Messaging in a Digital Weight Loss Intervention for Young Adults
The purpose of this micro-randomized trial is to evaluate the effects of 7 types of intervention messages targeting specific behavior change techniques (i.e., BCT messages) delivered in "just-in-time" (JIT) moments on daily…
- Conditions
- Obesity, Overweight, Overweight and Obesity
- Trial name
- Nudge (NCT05625061)
- Testing
- Core Behavioral Weight Loss (BWL) Intervention, Behavior Change Technique 1 Message (Action Planning), Behavior Change Technique 2 Message (Discrepancy between Current Behavior and Goal)
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of North Carolina, Chapel Hill
Psoriasis, Plaque Psoriasis
Role of Insulin Action in Psoriasis Pathogenesis
The goal of this study is to collect more information from people with plaque psoriasis and to determine if insulin plays a role in the pathogenesis of psoriasis.
- Conditions
- Psoriasis, Plaque Psoriasis, Insulin Resistance, PreDiabetes
- Trial name
- NCT06242847
- Testing
- Oral glucose tolerance test (OGTT), Skin punch biopsy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Type 1 Diabetes, Obesity
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
The main purpose of this study is to find out how well and how safely tirzepatide works long-term in adults who have type 1 diabetes and obesity or overweight. Participation in the study will last about 20 months.
- Conditions
- Type 1 Diabetes, Obesity, Overweight
- Trial name
- SURPASS-T1D-2 (NCT06962280)
- Testing
- Tirzepatide
- Where
- 79 sites in United States, Argentina and 8 more
- Volunteers
- 465 people
- Sponsor
- Eli Lilly and Company
Obesity and Overweight, Overweight or Obese
Innovative Functional Product for Overweight and Obesity
The aim of this randomized, parallel, two-arm, placebo-controlled, quadruple-blind clinical trial is to evaluate the efficacy of a polyphenol-enriched functional product in individuals with overweight or obesity, focusing…
- Conditions
- Obesity and Overweight, Overweight or Obese, Overweight or Obese Adults, Obese Subjects
- Trial name
- NCT07044167
- Testing
- Polyphenol-enriched functional product, Control without active polyphenols
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Carmen Lucas Abellán
Overweight, Obesity
A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants When Injected Under the Skin.
The study is testing a new medicine (NNC0487-0111) for weight control in Chinese people with BMI between 24 kilogram per meter square (kg/m2) and 34.9 kg/m2.
- Trial name
- NCT07121153
- Testing
- NNC0487-0111 A
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Novo Nordisk A/S
Overweight/Obesity, Metabolic Health
Composite Dietary Antioxidant Index and Metabolic Health in Overweight/Obesity in U.S. Adults
This cross-sectional study draws on data from the National Health and Nutrition Examination Survey (NHANES) database. The primary objective is to investigate the associations between the Composite Dietary Antioxidant Index (CDAI)…
- Trial name
- NCT07291726
- Testing
- None (Observational)
- Where
- China
- Sponsor
- University-Town Hospital of Chongqing Medical University
Osteogenesis Imperfecta, Osteoporosis
REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)
This study evaluates bone mineral density (BMD) in pediatric patients aged 5-18 years with conditions negatively affecting bone health, using REMS (Radiofrequency Echographic Multi Spectrometry), a non-invasive and radiation-free…
- Conditions
- Osteogenesis Imperfecta, Osteoporosis, Hypogonadisms, Neoplasia
- Trial name
- NCT07412782
- Testing
- REMS
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS
Obesity & Overweight
Characterization and Phenotyping of Patients Who Are Offered Drug Therapy for Obesity
The study is multicenter and observational, consisting of a cross-sectional phase (V0) in which data will be collected from patients who are offered drug therapy, and a prospective longitudinal phase in which only patients who…
- Trial name
- DrugsOb1 (NCT07414043)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Overweight , Obesity, Energy Metabolism
Mapping Metabolic Organ Plasticity in Energy Adaptation
Brief Summary (Plain Language) Many people who lose weight experience a slowdown in their metabolism that is greater than expected.
- Trial name
- MAP (NCT07415213)
- Testing
- Calorie Restriction (CR), Time Restricted Eating (TRE), Resistance Training (RT)
- Where
- Israel
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Obesity & Overweight, Hair Loss
Scalp Hair Metabolomics in Severe Obesity
The purpose of this research study is to investigate how body weight and weight-loss surgery affect the natural chemicals found in scalp hair over time.
- Conditions
- Obesity & Overweight, Hair Loss, Metabolomics, Bariatric Surgery
- Trial name
- NCT07368842
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Obesity & Overweight
Effects of Exercise on Lipids and Endothelial Function in Youth
This study is for individuals who have a BMI that is at or above the 95th percentile and are participating in the Cincinnati Children's Hospital Healthworks! Structured weight loss program.
- Trial name
- NCT07409064
- Testing
- Exercise Program
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Muscle Wasting, Obesity & Overweight
Testing the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss.
The goal of this clinical trial is to learn if BIO101 treatment can improve the muscle strength of participants males and females, aged 18 to 84 years old, suffering from obesity (BMI≥30) or overweight (BMI ≥ 27) with one or more…
- Conditions
- Muscle Wasting, Obesity & Overweight, Obesity
- Trial name
- OBA (NCT07411378)
- Testing
- BIO101, Semaglutide
- Volunteers
- 164 people
- Sponsor
- Biophytis
Overweight and Obesity, Adolescent Obesity
The BEE-Power Study (Boosting Exercise for Excellent Pediatric Blood Pressure)
The goal of this study is to compare two types of exercises, isometric exercise (like squats and planks) and aerobic exercise (such as running), to see which one is more effective at improving blood pressure in teenagers aged 13…
- Conditions
- Overweight and Obesity, Adolescent Obesity, Exercise
- Trial name
- NCT06444464
- Testing
- Aerobic exercise, Isometric exercise
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Overweight, Obesity
SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial
Participants are being asked to participate in SELECT-LIFE study because participants take part in the SELECT trial. SELECT-LIFE study is a survey-based study that will start when the SELECT trial ends.
- Trial name
- SELECT-LIFE (NCT04972721)
- Testing
- No treatment given
- Where
- 38 sites in United States, Algeria and 22 more
- Volunteers
- 3,439 people
- Sponsor
- Novo Nordisk A/S
Cancer Survivorship, Obesity
BfedBwell Proof-of-Concept Pilot
This single-arm proof-of-concept pilot will assess the feasibility and acceptability of integrating a survivorship nutrition intervention (BfedBwell) into an existing clinical exercise oncology program (BfitBwell).
- Conditions
- Cancer Survivorship, Obesity, Overweight
- Trial name
- NCT06191666
- Testing
- Group-based education and discussion, Individual 1:1 counseling, Group based behavioral skills development and cooking demonstrations
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Psoriasis (PsO), Obesity & Overweight
Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis
This study will evaluate the effects of oral semaglutide in combination with topical corticosteroid/calcipotriol on clinical outcomes and metabolic inflammation in patients with plaque psoriasis and overweight/obesity and/or type…
- Conditions
- Psoriasis (PsO), Obesity & Overweight, Diabetes Mellitus - Type 2
- Trial name
- SEMAPSO (NCT07401992)
- Testing
- Semaglutide (Rybelsus®)
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Obesity & Overweight
Postprandial Thermogenesis in Obese Adolescents: Effect of Weight Loss
The prevention and management of pediatric obesity require a thorough understanding and consideration of the various components of energy balance (i.e., intake and expenditure) and their interactions.
- Trial name
- TEFAL (NCT07400159)
- Testing
- Anthropometric measurements, Body composition assessment, Leeds Foods Preference Questionnaire
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Emile Roux
Overweight , Obesity, Overweight or Obese Adults
Improving Weight Loss in Healthy Adults With Overweight and Obesity: An Artificial Intelligence-assisted Dietary Prediction and Prevention System With Continuous Glucose Monitoring
This study aims to examine the effectiveness of a novel dietary lapse prediction and prevention self-regulation app called the eating behaviour trigger-response inhibition program (eTRIP), and the addition of continuous glucose…
- Conditions
- Overweight , Obesity, Overweight or Obese Adults, Obesity, Overweight and/or Obesity
- Trial name
- NCT07395466
- Testing
- eTRIP, FatSecret
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- National University Health System, Singapore
Mild Cognitive Impairment, Overweight or Obesity
The Efficacy and Safety of Metformin Intervention in Elderly Overweight or Obesity With Mild Cognitive Impairment
The prevalence of cognitive impairment in elderly obese patients is high, and the burden on families and society is heavy. Early intervention for mild cognitive impairment (MCI) is of great value.
- Conditions
- Mild Cognitive Impairment, Overweight or Obesity, Elderly
- Trial name
- NCT07395960
- Testing
- Metfomin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Fudan University
Overweight and Obesity
The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health
This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years)…
- Trial name
- NCT07395973
- Testing
- ketogenic nutritional Supplement, non-ketogenic, isocaloric control
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center