Clinical trials: Obesity
Obesity; Chronic Kidney Disease; Albuminuria
Study on the Efficacy and Safety of Initial Combination of Finerenone and Semaglutide in Non-Diabetic Adult Patients With Obesity Complicated by Chronic Kidney Disease With Albuminuria
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate whether starting finerenone together with semaglutide provides an additional reduction in urinary albumin-to-creatinine ratio…
- Trial name
- NCT07849348
- Testing
- Finerenone, Semaglutide
- Volunteers
- 266 people
- Sponsor
- Peking University People's Hospital
Obesity
A Study to Assess Safety, Tolerability, and Pharmacokinetics of MEDI0382 in Non-diabetic Obese Participants
This is a Phase 1, randomized, blinded, placebo-controlled study in up to approximately 51 non-diabetic obese participants with a body mass index (BMI) ≥ 35 kg/m^2.
- Trial name
- NCT03625778
- Testing
- MEDI0382
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- MedImmune LLC
Polycystic Ovary Syndrome, Overweight and Obesity
Lifestyle Intervention in Pregnant Women With PCOS
Polycystic ovarian syndrome (PCOS) is the most common reproductive disorder in women of childbearing age and is also associated with metabolic abnormalities including obesity, type 2 diabetes, dyslipidemia, etc.
- Conditions
- Polycystic Ovary Syndrome, Overweight and Obesity, Gestational Diabetes
- Trial name
- NCT04216485
- Testing
- Intensive Lifestyle Intervention, Standard Care
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Capital Medical University
Obesity
Exercise as a Buffer Against Stress-induced Overeating
The purpose of this study is to examine the psychological benefits of chronic exercise as well as the effects of exercise training on eating behaviors and stress-induced overeating in overweight and obese women.
- Trial name
- NCT02936076
- Testing
- Exercise intervention, Delayed exercise intervention
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Obesity, Inflammation
Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage
The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation.
- Trial name
- NCT04275674
- Where
- Taiwan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Obesity
Body Composition Outcomes in MS Patients
Objectives The objective of this project is to generate pilot data substantiating our hypothesis that advanced body composition measurement tools will provide more accurate and clinically relevant data on the outcomes of…
- Trial name
- BCOMS (NCT07530718)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pennington Biomedical Research Center
Body Weight, Insulin Resistance
The Effects of Calorie Restriction With or Without Metformin on Weight and Insulin Resistance
This is a study to: Determine the difference between strong hypo-energetic "standard diet advice" and modest hypo-energetic "personal diet advice"; and Determine the influence of insulin-insensitivity on obesity and weight…
- Trial name
- NCT00134290
- Testing
- metformin, "standard diet advice", "personal diet advice"
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University Hospital, Ghent
Overweight and Obesity
A Trial Comparing Two Approaches to Weight Loss
This study compared the recently developed Transforming Your Life (TYL) weight loss program to the Diabetes Prevention Program (DPP), considered the "Gold Standard" in behavioral weight loss treatment.
- Trial name
- NCT02671110
- Testing
- Transforming Your Life, Diabetes Prevention Program
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Robert Carels
Obesity, Overweight
Use of a Mobile Application by Parents to Prevent Obesity in Their Children Apply for Your Health
Background. Lifestyles that promote a positive energy balance increase the prevalence of obesity. Due to the magnitude of this problem, community-level strategies are required on how to provide families with useful information to…
- Trial name
- NCT07376252
- Testing
- Applícate por tu salud
- Where
- Mexico
- Volunteers
- 743 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Obesity, Chronic Kidney Diseases
Comparison of the Efficacy and Safety of SGLT2i and GLP-1 Receptor Agonists in Obese Patients With Kidney Disease
The goal of this clinical trial is to exploring the changes in 24-hour urinary protein and renal function in obese patients with kidney disease after the application of sodium glucose cotransporter 2 inhibitors (SGLT2i) and…
- Trial name
- NCT06344247
- Testing
- RAS inhibitors：Losartan®️/Valsartan®️, dapagliflozin：Forxiga®️, simagliptin：Forxiga®️
- Where
- China
- Volunteers
- 48 people
- Sponsor
- RenJi Hospital
PREG1, Obesity
Pilot Study: Identification of a Multi-omic Predictive Signature for Preterm Birth in Obese African American Women
1. Determine if the stool or vaginal microbiome and urinary metabolite profiles in a pregnant obese population of African American women differ from their pregnant non-obese counterparts 2.
- Trial name
- NCT03181555
- Testing
- Exploratory
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Baylor University
Inflammation, Obesity
Omega-3 Supplementation Decreases Inflammation and Fetal Obesity in Pregnancy
Randomized, double-blind placebo controlled trial of fish oil to decrease inflammation in pregnancy.
- Conditions
- Inflammation, Obesity, Pregnancy, Fetal Growth
- Trial name
- NCT00957476
- Testing
- Omega-3 Fish Oil
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Obesity
The Impact of a Pre-Operative Exercise Program on Fitness Outcomes Following Bariatric Surgery
BACKGROUND: Obesity is a global epidemic and Canada has one of the highest obesity rates in westernized countries. Obesity has many health related complications, including high blood pressure, high cholesterol, diabetes, sleep…
- Trial name
- NCT02010489
- Testing
- 12 week Exercise Program
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Obesity, Healthy
Effect of Bile Acids on Satiety, Cell Function and Body Weight in Patients With Obesity and Abnormal Satiety Phenotype
The purpose of this research is to study the effect of the study drug (a conjugated bile acid dietary supplement) or placebo on cell function, hormones and body weight.
- Trial name
- NCT05314374
- Testing
- Ileocolonic-release conjugated bile acid
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy, Obesity
A Study to Compare How 2 Different Formulations of Survodutide Are Taken up in the Body When Given by Injection in Healthy Men and Women With and Without Overweight or Obesity
The main objective of this trial is to establish the bioequivalence of survodutide in a pre-filled syringe (reference product [formulation A]) and in a vial (test product [formulation B2]) in male and female trial participants…
- Trial name
- NCT07768813
- Testing
- Survodutide formulation A, Survodutide formulation B2
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Obesity, Students
Improving Healthy Nutrition and Physical Activity Behaviors of University Students
There are many descriptive studies in the literature on health behaviors of university youth.However, there are a limited number of model-based interventional studies explaining the development of positive health behaviors of…
- Trial name
- NCT04195516
- Testing
- web based training,individual counseling, using reminders
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Morbid Obesity
Nonsurgical Reversible Obesity Treatment (NROT1)
The present study relates to apparatus and methods that can be applied using non-invasive techniques for effectively reducing nutrient absorption in the small intestines of obese people.
- Trial name
- NROT1 (NCT05420506)
- Testing
- NROT1
- Volunteers
- 20 people
- Sponsor
- Yeditepe University
Hypercholesterolemia, Hypertension
Evaluating "Health at Every Size"(HAES) as an Alternative Obesity Treatment Model
Increasingly more individuals are trying to lose weight. Indeed, many women, regardless of their size, experience a life-long battle and preoccupation with their weight.
- Conditions
- Hypercholesterolemia, Hypertension, Depression, Diabetes Mellitus, Type 2
- Trial name
- NCT00074633
- Testing
- Health at Every Size (HAES), Diet (Traditional, moderate energy restriction)
- Where
- 2 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Effects of GLP-1 RAs on Weight and Metabolic Indicators in Obese Patients
This studay evaluates the effect of the glucagon-like peptide-1 (GLP-1) receptor agonist,including Liraglutide,Exenatide and Exenatide Microspheres for Injection,in the treatment of subjects who are overweight or obese.
- Trial name
- NCT03671733
- Testing
- Liraglutide, Exenatide, Exenatide Microspheres for Injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xiangya Hospital of Central South University
Stress, Eating Behavior
Stress Reactivity Study in Adolescents
The goal of this study was to examine the glucocorticoid and behavioral responses to a psychological stressor in obese African-American and non-Latino white adolescents.
- Trial name
- SRAS (NCT03997149)
- Testing
- Acute Laboratory Stressor, Low affect video
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan