Clinical trials: Obesity
Feasibility and Acceptability of the TOPS Program, Obesity
TOPS for African American Breast Cancer Survivors
For women diagnosed with breast cancer, dietary, weight loss, and physical activity have been linked with clinically significant weight loss; decreased risk of death; reduced risk of breast cancer recurrence; fewer cardiovascular…
- Conditions
- Feasibility and Acceptability of the TOPS Program, Obesity, Breast Cancer, Weight Loss
- Trial name
- NCT04741802
- Testing
- TOPS
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Duke University
Obesity Prevention
A Web-Based Healthy Living Training for Promotores
The goal of this clinical trial is to test a new web-based promotora de salud/ community health worker (CHW) training. This training is designed to provide CHWs with the knowledge and skills to effectively implement a healthy…
- Trial name
- NCT06627439
- Testing
- Comadres Saludables, Control
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- ISA Associates, Inc.
Obesity
Study to Evaluate ARD-101 in Adults With Obesity
The purpose of this study is to evaluate safety and efficacy of twice-daily ARD-101 in obese subjects with a body mass index (BMI) of 30-45 kg/m2.
- Trial name
- NCT05121441
- Testing
- ARD-101
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Aardvark Therapeutics, Inc.
Overweight and Obesity
Circadian Timing, Information Processing and Energy Balance Study
This study design will test biological and behavioral mechanisms in the cross-sectional analyses and determine the prospective effects of circadian alignment and sleep on changes in cardiometabolic risk factors.
- Trial name
- TIME (NCT04759755)
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity, Weight Loss
Behavioral Mechanism of Energy Compensation With Exercise
Over 70% of Americans are either overweight or obese, putting them at risk for many chronic diseases including diabetes. Exercise is commonly used as a weight loss and weight loss maintenance strategy.
- Conditions
- Obesity, Weight Loss, Eating Behavior
- Trial name
- NCT04651218
- Testing
- exericse
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kyle Flack
Morbid Obesity, Metabolic Syndrome X
Randomized Comparison of Laparoscopic Sleeve Gastrectomy and Gastric Bypass for Morbid Obesity
Bariatric surgery is the most effective treatment for morbid obesity. Roux-en-Y gastric bypass (RYGB) is a bariatric procedure with known safety and effectiveness.
- Conditions
- Morbid Obesity, Metabolic Syndrome X, Diabetes Mellitus, Dyslipidemia
- Trial name
- NCT01806506
- Testing
- Laparoscopic sleeve gastrectomy, Roux-en-Y Gastric Bypass
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Medical University of Warsaw
Obesity, Insulin Resistance
Protection Against Insulin Resistance in Obesity
The overall goal of this project is to identify factors that "protect" some obese adults from becoming insulin resistant. Identifying mechanisms that help protect some obese adults from developing insulin resistance could lead to…
- Trial name
- PAIR (NCT02717832)
- Testing
- hyperinsulinemic-euglycemic clamp
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity
Virtual Lifestyle Management: Prevention Through the UPMC Patient Portal
Diabetes affects 18 million Americans and costs over $132 billion in both direct treatment and lost productivity per year. It is known that weight loss, improved diet and increased exercise can result in improvement in glucose…
- Trial name
- NCT00409786
- Testing
- Virtual Lifestyle Management (VLM)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Obesity, Status Post Sleeve Gastrectomy
Liraglutide (Saxenda(R)) in Adolescents With Obesity After Sleeve Gastrectomy
Background: Metabolic Bariatric Surgery, including a surgery called vertical sleeve gastrectomy, is the most effective weight loss treatment for severe obesity.
- Trial name
- NCT04883346
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sarcopenia, Gait Disorders in Old Age
A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT)
The main objective of the study is to evaluate the effect of two daily doses of BIO101 versus placebo on mobility function as measured by gait speed using the 400MW test.
- Conditions
- Sarcopenia, Gait Disorders in Old Age, Muscle Weakness
- Trial name
- SARA-INT (NCT03452488)
- Testing
- BIO101
- Where
- 22 sites in United States, Belgium
- Volunteers
- 233 people
- Sponsor
- Biophytis
Non-alcoholic Fatty Liver Disease (NAFLD), Non-alcoholic Steatohepatitis (NASH)
A Study to Evaluate Safety and Pharmacodynamic Efficacy of 0382 in Obese Subjects With NAFLD/NASH.
A Phase 2 study with 4 treatment groups of two differing doses and matched placebos designed to evaluate the safety (including hepatic safety), tolerability and pharmacodynamic effects of two dose levels of MEDI0382 in obese…
- Trial name
- NCT04019561
- Testing
- MEDI0382 high dose, MEDI0382 low dose
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 74 people
- Sponsor
- MedImmune LLC
Obesity, Aging
Semaglutide Use in Elderly Obese Patients
This is a single-center, prospective, controlled, randomized and open label study to investigate the effect of the semaglutide addition to standard of care weight loss intervention (personalized lifestyle and exercise) in elderly…
- Trial name
- NCT05302596
- Testing
- Semaglutide Pen Injector
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Pediatric Obesity, Childhood Obesity
A Pharmacokinetic Study Comparing VI-0521 With Placebo in Obese Adolescents
The primary objective of this study is to describe the pharmacokinetic profiles of VI-0521 in obese adolescents.
- Trial name
- NCT02714062
- Testing
- VI-0521 Mid Dose, VI-0521 Top Dose
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- VIVUS LLC
Type 2 Diabetes, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight
This is a study of tirzepatide in participants with type 2 diabetes who have obesity or are overweight. The main purpose is to learn more about how tirzepatide affects body weight. The study will last 79 weeks (22 visits).
- Conditions
- Type 2 Diabetes, Overweight, Obesity
- Trial name
- SURMOUNT-2 (NCT04657003)
- Testing
- Tirzepatide
- Where
- 75 sites in United States, Argentina and 6 more
- Volunteers
- 938 people
- Sponsor
- Eli Lilly and Company
Heart Failure With Preserved Ejection Fraction (HFpEF) and Diabetes Mellitus, Type 2
Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes
This study will look at how participants' daily life is affected by their heart failure. The study will also look at the change in participants' body weight.
- Trial name
- STEP HFpEF DM (NCT04916470)
- Testing
- Semaglutide
- Where
- 180 sites in United States, Argentina and 14 more
- Volunteers
- 617 people
- Sponsor
- Novo Nordisk A/S
Obesity, Insulin Resistance
Vitamin D Supplementation to Obese Chinese Males
Hypothesis: Oral Supplementation of Vitamin D can Reduce Hypersecretion of Parathyroid Hormone and Insulin Resistance in Obese Chinese Males.
- Trial name
- NCT01781169
- Testing
- Oral supplementation of vitamin D
- Where
- China
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Metastatic Breast Cancer, Obesity
Technology-Supported Physical Activity Intervention for Metastatic Breast Cancer Survivors: Fit2ThriveMB
This study will test the feasibility and acceptability of increasing PA in metastatic breast cancer (MBC) patients using a smartphone app, fitbit and coaching.
- Trial name
- NCT04129346
- Testing
- Fit2ThriveMB App, Fitbit, Physical Activity Coaching Calls
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Northwestern University
Binge-Eating Disorder, Obesity
Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Specialist Treatment
This study will test the effectiveness of cognitive-behavioral therapy as a specialist treatment for binge eating disorder (BED) in patients with obesity.
- Trial name
- NCT03063606
- Testing
- Cognitive-Behavioral Therapy (CBT), NB Medication (on-going from acute treatment)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Endotracheal Intubation, Rapid Airway Management Positioner
Evaluation of the Rapid Airway Management Positioner
The purpose of this study is to determine if the Rapid Airway Management Positioner (RAMP, AirPal, Center Valley, PA) is a useful positioning device for direct laryngoscopy and tracheal intubation in obese patients undergoing…
- Trial name
- RAMP (NCT00581230)
- Testing
- Laryngoscopy with RAMP, Laryngoscopy without RAMP
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity, Overactive Bladder
Trospium Chloride XR in Obese Female Patients With Overactive Bladder
This study evaluated the effectiveness of trospium chloride extended release (XR) in obese female patients with overactive bladder (OAB). Patients received either placebo and trospium chloride XR or placebo only.
- Conditions
- Obesity, Overactive Bladder, Incontinence
- Trial name
- NCT00932022
- Testing
- Trospium Chloride, Extended Release (XR)
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Allergan
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