Clinical trials: Obesity & Overweight
Prader-Willi Syndrome
PWS European Blood Bank for Infants and Controls From 0 to 48 Months
The present project aims to determine the underlying mechanisms for the switch from failure to thrive to excessive weight gain and hyperphagia with impaired satiety in PWS.
- Trial name
- NCT02529085
- Testing
- blood samples
- Where
- 6 sites in Belgium, France and 4 more
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Obesity, Endothelial Dysfunction
Effects of Body Mass Index on the Hyperemic Response to Regadenoson
We will test the hypothesis that a single dose of Regadenoson will produce equivalent degrees of coronary hyperemia in patients of widely different body size.
- Conditions
- Obesity, Endothelial Dysfunction, Decreased Vascular Flow
- Trial name
- NCT00859833
- Testing
- Adenosine, Regadenoson
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Opioid Use, Bariatric Surgery Candidate
Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery
The goal of this clinical trial is to compare the effects of Opioid Free Anesthesia (OFA) with and without volatile anesthetics (in this case desflurane) in patients undergoing bariatric surgery.
- Conditions
- Opioid Use, Bariatric Surgery Candidate, TCI Eleveld, Obesity
- Trial name
- NCT07568938
- Testing
- opioid free anesthesia, Opiod Free Anesthesia with TCI ELEVELD
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- G.Gennimatas General Hospital
Hepatitis
S-Adenosylmethionine Therapy for Non-Alcoholic Steatohepatitis
The purpose of this study is to examine the effect of S-adenosylmethionine therapy in those patients with non-alcoholic liver disease in the form of steatohepatitis (NASH).
- Trial name
- NCT00108589
- Testing
- S-adenosylmethionine
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Obesity
Assessment of the Impact of Body Position on Diaphragmatic Excursion in Obese Patients to Improve Proactice in Respiratory Kinesitherapy
The EXDECHO study is the first randomized study evaluating the effect of four body positions on diaphragmatic excursion in obese patients by ultrasound.
- Trial name
- EXDECHO (NCT05372250)
- Testing
- Measurement of the diaphragmatic excursion according to the position of the body by ultrasound
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Central Hospital, Nancy, France
Obesity
Signature Diagnostic of Non-alcoholic Steatohepatitis (NASH) by Infrared Light Spectroscopy
Evaluation of the diagnostic performance of an algorithm developed to detect metabolic profiles specific of non-alcoholic steatohepatitis NASH and based on the reading of a blood sample's infrared spectra
- Trial name
- SIGNALS (NCT03978247)
- Testing
- NASHMIR
- Where
- Belgium
- Volunteers
- 382 people
- Sponsor
- Diafir
Obesity, Anesthesia
Optimal Anesthesia for Morbidly Obese Patients
Obese patients have a higher risk of anesthesia compared to the non-obese, including difficult intubation, rapid desaturation, difficult vascular access, and delayed recovery from anesthesia.
- Trial name
- NCT04395248
- Testing
- Exploring potential risk factors of difficult intubation using ultrasound, Radial artery catheterization using ultrasound guidance or blind palpation, Comparing the effectiveness of preoxygenation between high-flow nasal cannula and facemask
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Anxiety, Obesity
Obesity and Mindful Eating in Patients With Anxiety
Background: Obesity is chronic disease with high prevalence rates, functional disability and difficult long-term management. Anxiety is one of the most common psychological disorders in obesity, and when associated with other…
- Conditions
- Anxiety, Obesity, Eating Behavior, Mindfulness
- Trial name
- OMETA (NCT06087185)
- Testing
- Mindful Eating, Video Group
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obesity, Morbid, Bariatric Surgery Candidate
Trends and Safety in Revisional Bariatric Surgery in Italy
Background: Revisional bariatric surgery (RBS) represents a further solution for patients who experience an inadequate response following initial bariatric surgery or significant weight regain following an initial satisfactory…
- Conditions
- Obesity, Morbid, Bariatric Surgery Candidate, Remission, Complication,Postoperative
- Trial name
- NCT05194943
- Testing
- revisional bariatric surgical procedures
- Where
- 11 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Roma La Sapienza
Childhood Obesity
Testing Digital Technologies to Help Families Build Healthy Habits
The current study is a randomized pilot trial to test the feasibility of a psychoeducational virtual reality experience to increase motivation for behavior change among children with overweight or obesity.
- Trial name
- NCT04845568
- Testing
- Virtual Reality Experience
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Washington University School of Medicine
Prediabetes, Obesity
Veterans Achieving Weight Loss and Optimizing Resilience-Using Protein
Diabetes is a major health concern in obese older Veterans, especially in those who are African American. The negative impact of diabetes on muscle and physical function contributes to metabolic as well as physical decline and is…
- Trial name
- VALOR-UP (NCT03835416)
- Testing
- Foods rich in high quality protein
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- VA Office of Research and Development
Obesity
High Density Lipoprotein Turnover
The objective of the study is to evaluate the effect of Rimonabant 20mg in comparison to placebo, on HDL and VLDL lipoprotein kinetics, over a 12 months period.
- Trial name
- NCT00408148
- Testing
- Rimonabant
- Where
- 4 sites in Australia, Finland and 2 more
- Volunteers
- 64 people
- Sponsor
- Sanofi
Body Weights and Measures, Body Weight in the Overweight and Obese Class - I Population
Machine Learning and 3D Image-Based Modeling for Real-Time Body Weight and Body Composition Estimation During Emergency Medical Care. Study 3
The goal of this randomized controlled clinical trial is to compare standard methods of weight estimation and drug dose calculations against weight estimates and dose calculations using a 3D camera weight estimation system in…
- Conditions
- Body Weights and Measures, Body Weight in the Overweight and Obese Class - I Population, Drug Dose, Weight Estimate
- Trial name
- NCT06645548
- Testing
- Weight estimation using 3D camera
- Sponsor
- Florida Atlantic University
Overweight/Obesity, Metabolic Health
Composite Dietary Antioxidant Index and Metabolic Health in Overweight/Obesity in U.S. Adults
This cross-sectional study draws on data from the National Health and Nutrition Examination Survey (NHANES) database. The primary objective is to investigate the associations between the Composite Dietary Antioxidant Index (CDAI)…
- Trial name
- NCT07291726
- Testing
- None (Observational)
- Where
- China
- Sponsor
- University-Town Hospital of Chongqing Medical University
Diabetes, Hypertension
Mobile Phone-based Intervention for Promoting Healthy Habits and Weight Loss
A self administered 16 weeks plus follow up study to explore the efficacy of mobile phone driven apps for stress reduction coupled with guidance for healthy living among obese and overweight populations.
- Conditions
- Diabetes, Hypertension, Pre-diabetes, Overweight
- Trial name
- NCT02621008
- Testing
- Stress Reduction& Healthy living
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Eco Fusion
Heart Failure, Obesity
WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise
The goal of this study is to define how treatment of obesity impacts cardiometabolic performance during exercise in patients with established HFpEF or at risk for HFpEF.
- Conditions
- Heart Failure, Obesity, Weight Loss, Heart Failure With Preserved Ejection Fraction
- Trial name
- WTLOSS-EX (NCT06576050)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Obesity
Clinic-based Nasopharyngoesophagogastroscopy Following Bariatric Surgery
This study aims to determine that this new technology, nasopharyngoendoscopy, is just as effective in diagnosing problems as the current gold standard.
- Trial name
- EGScan (NCT01602991)
- Testing
- clinic-based nasopharyngoendoscopy, Standard Endoscopy
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dennis Hong MD
Obesity
Using Partners to Enhance Long-Term Weight Loss
This study involves an evaluation of the role of domestic partner support in a comprehensive weight loss initiation and maintenance program.
- Trial name
- Partner2Lose (NCT03801174)
- Testing
- Partner-assisted intervention, Patient-only intervention
- Where
- United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Obesity, Polycystic Ovary Syndrome
Treatment of Obesity With Topiramate in Patients With Polycystic Ovary Syndrome
Treatment of obesity related to Polycystic Ovary Syndrome with topiramate or placebo to assess improvement of clinical and laboratory parameters after 6 months of follow-up
- Conditions
- Obesity, Polycystic Ovary Syndrome, Hyperandrogenism
- Trial name
- NCT04453306
- Testing
- Topiramate
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Metabolic Syndrome X
Clinical Trial of Chinese Formula AMP-1915 on Metabolic Syndrome
The purpose of this study is to determine whether the Chinese formula AMP-1915 has effect on Metabolic Syndrome (MS) in MS patients. Half of patients received AMP-1915, while the other half received placebo.
- Trial name
- NCT02605655
- Testing
- AMP-1915
- Volunteers
- 60 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine