Clinical trials: Obesity & Overweight Sleep
Obesity, Sleep
The Impact of Phone Use on Everyday Outcomes
Participants will download a phone-tracking app for a week to track phone usage, providing objective data on usage patterns. Quantitative tasks and questionnaires will also be carried out before and after the tracking period.
- Conditions
- Obesity, Sleep, Depression, Anxiety
- Trial name
- NCT04303637
- Testing
- Phone use
- Where
- Singapore
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Metabolic Syndrome, PreDiabetes
Exercise, Sleep Quality and Nocturnal Fat Oxidation in Metabolic Syndrome
The purpose of the Exerci-Zzz Study is to learn more about how the time of day that exercise is performed influences sleep quality and fat metabolism overnight in adults with metabolic syndrome.
- Conditions
- Metabolic Syndrome, PreDiabetes, Hypertension, Obesity
- Trial name
- ExerciZzz (NCT04105218)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Obesity Hypoventilation Syndrome (OHS)
Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity [body mass index (BMI) ≥30 kg/m2], chronic daytime hypercapnia (PaCO2 >45 mm Hg), and sleep-apnea in the absence of other known causes of hypercapnia.
- Trial name
- NCT04835558
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Overweight and Obese Adults
Behavioral Weight Loss and Sleep Health Intervention
This is a 6-month single-arm pilot and feasibility study designed to examine if a behavioral weight loss (BWL) intervention with an added sleep health program (BWL+SLEEP) can achieve clinically meaningful weight loss and…
- Trial name
- DREAM (NCT07255287)
- Testing
- BWL+Sleep
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnoea, Obesity
Obstructive Sleep Apnoea and Adipose Tissue Dysfunction
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea.
- Conditions
- Obstructive Sleep Apnoea, Obesity, Hypoxia
- Trial name
- NCT02518633
- Testing
- Continuous positive airway pressure devices
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Obstructive Sleep Apnea, Obesity
Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea
The purpose of this study is to evaluate the effect and safety of tirzepatide in participants with moderate to severe obstructive sleep apnea and obesity who are both unwilling or unable to use Positive Airway Pressure (PAP)…
- Trial name
- SURMOUNT-OSA (NCT05412004)
- Testing
- Tirzepatide
- Where
- 58 sites in United States, Australia and 8 more
- Volunteers
- 469 people
- Sponsor
- Eli Lilly and Company
Diabetes Type 2, Overweight or Obesity
Effect of the Thrive AI Health App on Lifestyle Behaviors and Quality of Life
The goals of this randomized trial is to learn: 1. If the Thrive AI Health app will help adults improve their everyday habits (diet, exercise, and sleep). 2.
- Trial name
- NCT07376655
- Testing
- App
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Cardiometabolic Syndrome, Type 2 Diabetes
Circadian Intervention to Improve Cardiometabolic Health
The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD).
- Conditions
- Cardiometabolic Syndrome, Type 2 Diabetes, Sleep, Time Restricted Feeding
- Trial name
- TOCS (NCT05943626)
- Testing
- Circadian Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity
Sleep Timing on Energy Intake and Energy Expenditure
Studies in healthy young adults have shown that abnormal and undesirable physiological changes are a result of chronic sleep curtailment, with implications on inflammatory status, blood glucose regulation, circulating free fatty…
- Trial name
- NCT05096585
- Testing
- Delayed bedtime sleep restriction, Early wake sleep restriction
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity, Pregnancy
Sleep Apnea, Obesity and Pregnancy
Main objective: Determine the prevalence of obstructive sleep apnea syndrome (OSA) in late pregnancy in a population of obese patients .
- Trial name
- GOS (NCT02029859)
- Testing
- Polygraphic examination
- Where
- 4 sites in France
- Volunteers
- 205 people
- Sponsor
- University Hospital, Rouen
Obstructive Sleep Apnea, Obesity
Comparison of Apnea-Hypopnea Index in Patients With or Without Preventive Oxygen Therapy After Bariatric Surgery
The best perioperative strategy for obstructive sleep apnea (OSA) in bariatric surgery remains unclear. A strategy is to monitor patients and administer preventive oxygen therapy during the first postoperative night.
- Conditions
- Obstructive Sleep Apnea, Obesity, Bariatric Surgery Candidate
- Trial name
- OXYBAR (NCT06432933)
- Testing
- No preventive oxygen therapy (2L), Preventive oxygen therapy (2L) standard care
- Where
- Netherlands
- Volunteers
- 153 people
- Sponsor
- Rijnstate Hospital
Insulin Resistance
Effect of 10-day Overnight Hypoxia Treatment on Whole Body Insulin Sensitivity (SLEEP HIGH Study)
The purpose of this study is to look at how a reduction in oxygen levels (hypoxia) influences insulin sensitivity and carbohydrate metabolism.
- Trial name
- SLEEP HIGH (NCT01872533)
- Testing
- Hypoxia Exposure
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Obstructive Sleep Apnoea Syndrome
Study of Eating Behaviour and Sense of Taste Before and After Treatment With Nocturnal Continuous Positive Airway Pressure in Overweight Patients With Obstructive Sleep Apnea Syndrome.
Obstructive sleep apnea (OSA) is characterized by a repeated partial or complete obstruction of the airway that results in a intermittent hypoxia and sleep disturbance.
- Trial name
- GOUSAS (NCT03701737)
- Testing
- questionnaires, wrist actimeter, Blood samples
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Sleep Apnea Syndromes, Metabolic Syndrome
Evaluating of the Impact of a Connected and Non-intrusive Device in Improving the Screening of Sleep Apnea Syndrome and the Addressing of Potentially Pathological Patients in Hospital Environment
Diabetes, obesity and metabolic syndrome are closely linked to sleep apnea syndrome. Indeed, diabetic and/or obese patients present an increased risk of sleep apnoea syndrome (SAS), with a prevalence estimated at between 10 and…
- Conditions
- Sleep Apnea Syndromes, Metabolic Syndrome, Diabetes, Obese
- Trial name
- AMELIAS (NCT06141967)
- Testing
- WITHINGS Sleep Analyzer
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Obstructive Sleep Apnea, Obesity
Sibutramine Versus Continuous Positive Airway Pressure (CPAP)in Obstructive Sleep Apnea (OSA) Patients
The primary objective of this study is to observe if Sibutramine is effective in improving the symptoms and signs of sleep apnea in obese patients.
- Conditions
- Obstructive Sleep Apnea, Obesity, Hypertension
- Trial name
- NCT00729963
- Testing
- Sibutramine, CPAP
- Volunteers
- 45 people
- Sponsor
- Laval University
Sleep Apnea, Obstructive, Obesity
A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight
The purpose of the studies is to evaluate the efficacy and safety of eloralintide in participants with moderate-to-severe obstructive sleep apnea and obesity or overweight.
- Conditions
- Sleep Apnea, Obstructive, Obesity, Overweight
- Trial name
- ENLIGHTEN-3 (NCT07369011)
- Testing
- Eloralintide
- Where
- 115 sites in United States, Australia and 9 more
- Volunteers
- 800 people
- Sponsor
- Eli Lilly and Company
Sleep Deprivation, Obesity
Sleep and Metabolism
The goal of this study is to uncover sleep and circadian mechanisms contributing to adverse metabolic health. The protocol is a 21 day (7 outpatient days, 14 inpatient days) mechanistic randomized-crossover study designed to…
- Conditions
- Sleep Deprivation, Obesity, Glucose Intolerance, Weight Gain
- Trial name
- SAM (NCT05775627)
- Testing
- Sleep Restriction
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Diabetes Mellitus, Hypertension
Safety and Efficacy of Xenical in Children and Adolescents With Obesity-Related Diseases
Obesity is a condition affecting one-third off the U.S. population and is a major risk actor for the development of Type 2 diabetes, hyperlipidemia (increased levels of fat in the blood), hypertension (high blood pressure), and…
- Conditions
- Diabetes Mellitus, Hypertension, Metabolic Disease, Obesity
- Trial name
- NCT00001723
- Testing
- Orlistat
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jack Yanovski
Obesity
Sleep, Exercise and Insulin Sensitivity
Insufficient or disrupted sleep, lack of physical activity and poor diet are linked with obesity and are now potential targets to combat obesity.
- Trial name
- NCT03556410
- Testing
- sleep, exercise
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
PreDiabetes, Obesity
Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes
Purpose of the Study: This study is to learn more about how exercising at different times of the day (morning versus evening) affects metabolism of glucose in the body, sleep, activity outside of exercise, and other factors.
- Conditions
- PreDiabetes, Obesity, Inactivity/Low Levels of Exercise
- Trial name
- TExIS (NCT06292000)
- Testing
- AM Exercise, PM Exercise
- Where
- United States
- Sponsor
- University of Colorado, Denver