Clinical trials: Obesity (BMI>30)
Pregnancy Related, Obesity
Misoprostol Dosing in BMI Greater Than 30
The investigators are performing a randomized controlled-trial investigating if 50mcg (compared to 25 mcg) of vaginal misoprostol reduces the time from induction start to delivery in obese women.
- Conditions
- Pregnancy Related, Obesity, Labor Onset and Length Abnormalities
- Trial name
- MD30 RCT (NCT05262738)
- Testing
- 50 Micrograms Vaginal Misoprostol (Intervention), 25 Micrograms Vaginal Misoprostol (Control)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Texas at Austin
Asthma, Allergic, Asthma
IL13 Signaling in Allergic Asthma
This study will investigate the role of dupilumab in the treatment of asthma with comorbid obesity. It is hypothesized that in airway epithelial cells, unique transcriptomic and proteomic expression patterns distinguish allergic…
- Conditions
- Asthma, Allergic, Asthma, Obesity
- Trial name
- NCT05478824
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Prediabetes, Obesity (Body Mass Index >30 kg/m2)
Behavioral Approach for Latinas Addressing Nutrition, Cravings, and Eating Patterns to Prevent Type 2 Diabetes
Adapt the Regulation of Cues (ROC) treatment program for Latinas to see if it can treat prediabetes and prevent developing of Type 2 Diabetes and reduce weight.
- Trial name
- BALANCE (NCT07478263)
- Testing
- Regulation of Cues
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Obesity and Cardiovascular Risk, Insulin Resistance
Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)
Obesity is a chronic disease of global public health concern, contributing to cardiovascular disease, type 2 diabetes and certain cancers.
- Conditions
- Obesity and Cardiovascular Risk, Insulin Resistance, Obesity (Body Mass Index >30 kg/m2)
- Trial name
- MOWRI (NCT07297290)
- Testing
- Metformin
- Where
- 2 sites in Nigeria
- Volunteers
- 220 people
- Sponsor
- University Of Nigeria Teaching Hospital
Obese Patients (BMI ≥ 30 kg/m²), Obese Patients
Modifications to Gastric Sleeve: Implications for GRED and Quality of Life
This is a prospective randomized clinical trial evaluating the impact of antrum and fundus calibration during laparoscopic vertical gastrectomy (VG) on postoperative gastroesophageal reflux disease (GERD), quality of life, and…
- Conditions
- Obese Patients (BMI ≥ 30 kg/m²), Obese Patients, Obese Patients With Bariatric Surgery, Obese With Comorbidities
- Trial name
- NCT07070908
- Testing
- Antrum calibration, Fudus calibration, No antrum calibration
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital San Juan de Dios Tenerife
Overweight (BMI > 25), Obesity (Body Mass Index >30 kg/m2)
Real-World Two-Year Weight Loss Outcomes With Breath Biofeedback
The goal of this retrospective observational study is to evaluate the real-world durability of weight loss among adults with overweight or obesity who used the Key to Health breath-biofeedback mHealth program.
- Conditions
- Overweight (BMI > 25), Obesity (Body Mass Index >30 kg/m2), Obesity & Overweight
- Trial name
- NCT07430618
- Testing
- Breath acetone biofeedback device with mHealth program
- Where
- Canada
- Volunteers
- 11,524 people
- Sponsor
- University of British Columbia
Obesity (BMI>30), Metabolically Healthy Obesity
Plasma Taurine in Older Women With Obesity: Impact of Metabolic Phenotype and Combined Exercise
Population aging has been accompanied by a rise in obesity and other chronic diseases, increasing cardiovascular risk particularly among women, who exhibit a higher prevalence in older age groups compared to men.
- Conditions
- Obesity (BMI>30), Metabolically Healthy Obesity, Metabolically Unhealty Obese
- Trial name
- non applicable (NCT07711899)
- Testing
- Physical Training of 16 weeks
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Central Abdominal Bulging
Safety and Efficacy Study of LIPO-202 for the Reduction of Central Abdominal Bulging in Obese Subjects
This is a multi-center, randomized, placebo-controlled, double-blind study evaluating the safety and efficacy of LIPO-202 for the reduction of central abdominal bulging in obese subjects.
- Trial name
- NCT02568319
- Testing
- LIPO-202
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- Neothetics, Inc
Hypertension ,Pregnancy, Diabetes During Pregnancy
Impact of Exercise Prescription on Obstetric and Neonatal Outcomes
The aim of this study is to assess the impact of structured physical activity with smartwatch remote monitoring on glycemic control, blood pressure control, obstetric complications and neonatal outcomes in women with GDM, chronic…
- Conditions
- Hypertension ,Pregnancy, Diabetes During Pregnancy, Obesity (BMI>30)
- Trial name
- NCT07678944
- Testing
- Physical activity plan, Women who received information but did not engaged in a physical activity routine
- Where
- Portugal
- Volunteers
- 310 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Obesity
The ABEL Feasibility Study (Adherence, Better Health, Exercise and Life Satisfaction)
The ambition of the ABEL feasibility study is to test new "green prescription" follow-up models that can get more women with obesity, regularly active, with improved health and physical fitness.
- Trial name
- NCT05792657
- Testing
- High dosage in-person exercise coaching, Medium dosage in-person exercise coaching., Low dosage in-person exercise coaching
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Norges idrettshøgskole
Obesity (BMI Equal to or >30), Immune Function
Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles
The purpose of this intervention study is to investigate the effects of daily egg intake on markers of gut health, high-density lipoprotein (HDL), metabolic, and immune cell profiles in adults with body mass indexes (BMI) in…
- Conditions
- Obesity (BMI Equal to or >30), Immune Function, HDL, Gut Microbiome
- Trial name
- NCT07844616
- Testing
- Egg whites, Whole eggs
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Obesity (BMI>30), Obesity & Overweight
Allurion Gastric Balloon PAS
The primary purpose of this study is to confirm the safety profile results for the Allurion Gastric Balloon System (AGBS).
- Trial name
- NCT07684664
- Testing
- Active Elipse Device
- Volunteers
- 250 people
- Sponsor
- Allurion Technologies
Obesity, Healthy
Effect of Bile Acids on Satiety, Cell Function and Body Weight in Patients With Obesity and Abnormal Satiety Phenotype
The purpose of this research is to study the effect of the study drug (a conjugated bile acid dietary supplement) or placebo on cell function, hormones and body weight.
- Trial name
- NCT05314374
- Testing
- Ileocolonic-release conjugated bile acid
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertension
A Clinical Study to Compare Combination of Aliskiren+ HCTZ to Irbesartan+ HCTZ or Amlodipine+ HCTZ or HCTZ Alone in Obese Hypertensive Not Responsive to HCTZ 25 mg
To evaluate the blood pressure lowering effects of the combination of aliskiren 300 mg and HCTZ 25 mg in obese patients with essential hypertension inadequately treated with HCTZ 25 mg, compared to irbesartan or amlodipine with…
- Trial name
- NCT00219115
- Testing
- aliskiren
- Where
- 2 sites in United States, Germany
- Volunteers
- 493 people
- Sponsor
- Novartis
Obesity/Therapy, Obesity (Body Mass Index >30 kg/m2)
Virtual Reality Training on Balance, Postural Stability, Mobility and Quality of Life in Obese Patients
The aim of this study will be to evaluate the effect of adding Virtual reality training to balance exercise program on improving Balance, Postural Stability, mobility and Quality of life in obese patients.
- Trial name
- NCT07006870
- Testing
- Virtual Reality plus Balance Exercise Training, Balance Exercise Training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Diabetes Mellitus, Metabolic Surgery
Metabolic Surgery; Gastric Bypass vs Sleeve Gastrectomy; Efects Over Type 2 DM With Bad Metabolic Control (MSO1CT)
The aim of the study is to compare the efficacy of laparoscopic gastric bypass versus vertical gastrectomy for the resolution of DM in patients with BMI 30-35.
- Conditions
- Diabetes Mellitus, Metabolic Surgery, Sleeve Gastrectomy, BPGY
- Trial name
- MSO1CT (NCT03891056)
- Testing
- metabolic surgery
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitario Doctor Peset
Obesity (BMI>30), Immune Abnormalities
NutrImmune: Precision Nutrition to Improve Immunity in Individuals With Obesity
Obesity is a complex health condition defined by the World Health Organization (WHO) as an excess of body weight that may be harmful to health.
- Conditions
- Obesity (BMI>30), Immune Abnormalities, Low-grade Inflammation
- Trial name
- NutrImmune (NCT07850206)
- Testing
- Mixed test meal, Biological sampling, Questionnaires
- Where
- 4 sites in France, Germany and 1 more
- Volunteers
- 168 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity Complicating Childbirth
Weekly Antepartum Testing in Women With BMI 30-40 and Neonatal Outcomes
The purpose of study is to evaluate whether weekly antenatal testing in pregnant women with body mass index (BMI) 30-40 in the third trimester is associated with earlier delivery when compared to growth ultrasounds every 4 weeks.
- Trial name
- NCT04180566
- Testing
- Ultrasound Examination, Antenatal Testing (biophysical profile)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
Orthopedic Procedures, Obesity
Effect of BMI on Postoperative Morbidities of Orthopaedic Procedures
Obesity is associated with poor surgical outcome and complications. The literature does not provide a comprehensive view on the effect of body mass index (BMI) on perioperative outcomes in orthopedic surgeries.
- Trial name
- BMIORTHO (NCT04827888)
- Testing
- Orthopaedic surgery
- Where
- Lebanon
- Volunteers
- 76,189 people
- Sponsor
- American University of Beirut Medical Center
Obese Patients (BMI ≥ 30 kg/m²), Anxiety
Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity.
Obese individuals are a particularly vulnerable population for mental health problems, especially depression and anxiety. The aim of this study is to evaluate whether the intake of a synbiotic, composed of prebiotics and…
- Conditions
- Obese Patients (BMI ≥ 30 kg/m²), Anxiety, Depressive Disorder
- Trial name
- NCT06901739
- Testing
- Synbiotic
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Celia Bañuls