Clinical trials: Obesity (BMI > 35), open to volunteers
Obese
Mechanical Ventilation in Obese Surgical Patients
The purpose of this study is to evaluate whether an intraoperative positive end-expiratory pressures (PEEP) setting strategy aimed at minimizing the mechanical power delivered to the lungs via transpulmonary pressure improves…
- Trial name
- NCT07774065
- Testing
- Standard PEEP (8 cmH₂O)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Normal Healthy Adults
A Research Study to Evaluate BLX-0871 in Healthy Adults
This study will test an oral medicine called BLX-0871, which is being developed to improve metabolic health by activating AMP-activated protein kinase (AMPK), a key regulator of energy balance.
- Trial name
- NCT07140081
- Testing
- BLX-0871
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Biolexis Therapeutics
Obesity (BMI > 35), Difficult Airway
Ultrasound vs Clinical Parameters for Difficult Airway Prediction in Obesity
Obesity is associated with anatomical changes in the upper airway that increase the risk of difficult laryngoscopy and difficult mask ventilation during anesthesia.
- Conditions
- Obesity (BMI > 35), Difficult Airway, Difficult Airway Intubation, Difficult Mask Ventilation
- Trial name
- NCT07528677
- Testing
- Airway Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Normal Healthy Volunteer, Safety After Oral Intake
A Research Study to Evaluate BLX-7006 in Healthy Adults
This study will test an oral medicine called BLX-7006, which acts like the hormone Glucagon-like Peptide-1 (GLP-1) to help control blood sugar and body weight. Current GLP-1 medicines are given by injection.
- Trial name
- NCT07140055
- Testing
- BLX-7006
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Biolexis Therapeutics
Obesity (BMI > 35) and Diabetes Mellitus, Obesity (BMI > 35) and Dyslipemia
Preoperative Optimization With Tirzepatide, Ketogenic Diet, or Standard Care Before One Anastomosis Gastric Bypass Surgery
This study compares three preoperative strategies before one anastomosis gastric bypass(OAGB) for severe obesity. Participants will be assigned to receive either tirzepatide medication for 60 days, a ketogenic diet for 4 weeks…
- Conditions
- Obesity (BMI > 35) and Diabetes Mellitus, Obesity (BMI > 35) and Dyslipemia, Obesity (BMI > 35) and High Blood Pressure
- Trial name
- OPTI-OAGB (NCT07622992)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- Mario Musella MD
Obesity (BMI > 35)
The OB-WELL Project, a Randomized Controlled Trial of an Internet-Based Self-Help System for Psychological Support in Obesity
Objective: This study aims to evaluate the feasibility and effectiveness of the OB-WELL program, an internet-based self-help intervention grounded in the principles of Cognitive Behavioral Therapy (CBT) and Brief Strategic…
- Trial name
- NCT07476599
- Testing
- BST Internet-based intervention, CBT Internet-based intervention
- Where
- Italy
- Volunteers
- 224 people
- Sponsor
- Catholic University of the Sacred Heart
Obesity (BMI > 35)
Preserving Muscle Mass During Incretin-Induced Weight Loss
Treatment with incretin-based obesity medications leads to clinically meaningful weight loss and reduced cardiometabolic risk. However, the weight lost includes not only adipose tissue but also skeletal muscle, which may impair…
- Trial name
- INCRETraIN (NCT07761923)
- Testing
- Unilateral Resistance Training
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Overweight/Obesity (BMI: 27 and 35 kg/m2)
tVNS and Obesity-related Mechanisms
The overarching goal of the project is to assess whether transcutaneous Vagus Nerve Stimulation (tVNS) induced reduction of central and peripheral inflammation is associated with tVNS induced changes in mood and motivation in a…
- Trial name
- NCT06954844
- Testing
- Transcutaneous non-invasive vagus nerve stimulation (tVNS), Low intensity stimulation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Obesity (BMI > 35), Obesity (BMI > 35) and Diabetes Mellitus
HUGO-SLEEVE: Evaluating the Feasibility of Robotic Sleeve Gastrectomy With a New Platform
Severe obesity is a chronic condition that can lead to a range of serious health problems. One common treatment option is sleeve gastrectomy, a weight-loss operation in which the size of the stomach is reduced.
- Conditions
- Obesity (BMI > 35), Obesity (BMI > 35) and Diabetes Mellitus, Obesity (BMI > 35) and Dyslipemia, Obesity (BMI > 35) and High Blood Pressure
- Trial name
- NCT07884994
- Testing
- Sleeve Gastrectomy using Hugo RAS platform
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Obesity (BMI > 35), Bariatric Surgery
Digital Follow-Up and Nursing Education in Bariatric Surgery Patients
This randomized controlled experimental study aims to evaluate the effect of a PHP-MySQL database-based digital follow-up system combined with structured nursing education on quality of life, body mass index (BMI), and exercise…
- Trial name
- DigiBarQoL (NCT07457034)
- Testing
- Structured Nursing Education and Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Okan University