Clinical trials: Obesity /Overweight
Obesity
Daily Habits & Consumer Preferences Study
The study will use a between-subjects design in a sample of individuals with BMI greater than or equal to 28 from the Los Angeles community (N=330). Participants will be randomly assigned to a weight stigma vs.
- Trial name
- NCT05402137
- Testing
- Weight stigma intervention
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity, Hypertension
The Effects of Metformin on Blood Vessel Structure and Function
The purpose of this study is to evaluate whether the drug Metformin has beneficial effects on the blood vessels of individuals with the Metabolic Syndrome (MeS).
- Conditions
- Obesity, Hypertension, Hypercholesterolemia, Hyperglycemia
- Trial name
- NCT00105066
- Testing
- Metformin
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- National Institute on Aging (NIA)
Asthma, Obesity
Role of Cysteinyl Leukotrienes in the Pathogenesis of Asthma in Obesity
The purpose of this study is to examine whether there are higher levels of cysteinyl leukotrienes in obese subjects than in non-obese subjects.
- Trial name
- NCT01158573
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obese With Comorbidities, Overweight With Comorbidities
Study for Multiple Doses of HM15136(Efpegerglucagon) in Obese or Overweight Subjects With Comorbidities
The planned period of each cohort is 22 weeks including subject screening, treatments for 12 weeks, and follow up period.
- Conditions
- Obese With Comorbidities, Overweight With Comorbidities, Type2 Diabetes
- Trial name
- NCT04167553
- Testing
- HM15136
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Incomplete Reversal of Neuromuscular Block
Sugammadex ED90 Dose in the Obese Patients
The purpose of this study is to determine the minimum effective dose of sugammadex, an antagonist of neuromuscular blockade used during anesthesia practice, in obese patients, considering that sugammadex is indicated in adults…
- Trial name
- NCT02568345
- Testing
- sugammadex ED90
- Volunteers
- 31 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Healthy
Pharmacokinetics of Voriconazole in Obese Subjects
Obese subjects may require a higher fixed oral maintenance dosing regimen of voriconazole compared to normal weight subjects to achieve comparable plasma exposures. The current study is designed to address this issue.
- Trial name
- NCT01030653
- Testing
- Voriconazole low dose, Voriconazole high dose
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Manjunath Prakash Pai
Obesity, Obesity, Childhood
Healthy Homes, Healthy Habits
The purpose of this study is to evaluate whether an intervention targeting healthy habit development reduces the risk and prevalence of obesity in low-income mothers and children.
- Conditions
- Obesity, Obesity, Childhood, Obesity; Familial
- Trial name
- HABITS (NCT03433456)
- Testing
- Home visitation + HABITS program, Standard home visitation program
- Where
- United States
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Overweight, Obese
Ideas Moving Parents and Adolescents to Change Together (IMPACT)
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institute of Health (NIH) has sponsored a consortium of four sites across the United States, entitled Childhood Obesity Prevention and Treatment Research…
- Trial name
- IMPACT (NCT01514279)
- Testing
- HealthyCHANGE, SystemCHANGE
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Case Western Reserve University
Obesity, Pain
Intravenous Acetaminophen Use With Bariatric Surgery on Morbidly Obese Patients
Bariatric patients usually require the use of either intravenous or oral opioid medications. The use of opioids, however, is often associated with side-effects such as nausea, sedation pruritus, urinary retention and respiratory…
- Trial name
- NCT01527942
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Trinity Health Of New England
Obesity
Communicating Risk Information for Obesity
This study will examine the impact of providing genetic risk information for obesity on people's attitudes and beliefs about obesity, health behaviors and weight outcomes.
- Trial name
- NCT01355224
- Testing
- Genetic, Lifestyle
- Where
- United States
- Volunteers
- 798 people, healthy volunteers welcome
- Sponsor
- Boston University
Obesity
Effect of GLP-1 Receptor Agonism After Sleeve Gastrectomy
Observational studies suggest that bariatric surgery is the most effective intervention for weight loss. Comparative effectiveness of Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG) demonstrate that RYGB is…
- Trial name
- NCT03115424
- Testing
- Saxenda, RYGB
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity, Insulin Resistance
Correction of Vitamin D Levels and Its Effect on Insulin Resistance and Weight Gain in Obese Youth
Vitamin D deficiency is extremely common in obese youth. In our obese population followed in the Endocrinology clinic at Children's Medical Center Dallas, vitamin D levels were inversely correlated with a measure of insulin…
- Conditions
- Obesity, Insulin Resistance, Vitamin D Deficiency
- Trial name
- NCT02168660
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Perrin C White, MD
Pediatric Obesity
Quincy Family, Youth & Technology For Lifestyle Change (FYT-4-LIFE) Study
To date, approaches that show the most promise for preventing and/or reversing the course of childhood obesity involve the delivery of intensive lifestyle interventions within a family-based context, emphasizing the necessity of…
- Trial name
- QFYT (NCT02324361)
- Testing
- Physical Activity, Evidence-based information on healthy family routines
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Feeding Behavior, Obesity
Neuronal and Behavioral Effects of Implicit Priming in Obese Individuals
The overall goals of this project are to determine the impact of an implicit priming intervention, designed to alter food perceptions, on both brain responses to food and on food intake behaviors in overweight/obese individuals.
- Conditions
- Feeding Behavior, Obesity, Overweight
- Trial name
- NCT02347527
- Testing
- Active Implicit Priming, Control Implicit Priming
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Metabolic Syndrome
Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment
To determine whether the combination of ezetimibe and simvastatin improves biomarkers of atherothrombosis compared to simvastatin alone in patients with the metabolic syndrome.
- Trial name
- NCT00819403
- Testing
- simvastatin, ezetimibe/simvastatin
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Obesity, Visceral, Obesity; Endocrine
Study of Lipolysis of Visceral Reserve Fat Using Tecar Therapy.
The Scope of this study is to assess the visceral and subcutaneous fat loss in patients having Tecar (Radiofrequency) Therapy and its effects on other anthropometric variables, adipokines and inflammation.
- Trial name
- NCT06377358
- Testing
- Tecar Therapy
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CAPENERGY MEDICAL, SL
Obesity, Vitamin D Deficiency
Efficacy of Vitamin D Supplementation in Bariatric Surgery Patients
As the use of bariatric surgery for treatment of extreme obesity adults continues to rise, clinicians must be aware of pre-existing nutritional deficiencies in overweight and obese patients.
- Trial name
- NCT01385098
- Testing
- Vitamin D3 and Calcium
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Vadim Sherman, MD
Obesity, Healthy
Sympathetic Activation in Obesity
The primary objective of this study is to determine whether sympathetic nervous system (SNS) activity in white adipose tissue (WAT) and brown adipose tissue (BAT), skeletal muscle and brain is altered in individuals with obesity…
- Trial name
- NCT04946552
- Testing
- PET Scan, Mixed Meal Test, Muscle sympathetic nerve activity (MSNA)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Food Preferences, Obesity
Online Food and Beverage Labels and Vending Machine Selections
The aim of this study is to compare the impact of 5 different types of front of package (FOP) food and beverage labels: 1) calorie labels [control], 2) green labels on healthy foods, 3) red/yellow/green labels on less…
- Conditions
- Food Preferences, Obesity, Weight Gain
- Trial name
- VLO (NCT05432271)
- Testing
- Exposure to calorie information, Exposure to healthy labels only, Exposure to healthiness information
- Where
- United States
- Volunteers
- 8,145 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity
Peripheral Pharmacodynamics of Phentermine-Topiramate in Obese Patients
Our overall goal is to determine the effect of Phentermine and Topiramate ER on gastric emptying, gastric accommodation, satiety, and satiation in obese participants.
- Trial name
- NCT01834404
- Testing
- Phentermine-Topiramate ER
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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