Clinical trials: Obesity /Overweight
Type 2 Diabetes
Exeantide in Type 2 Diabetes on Insulin
Exenatide has been shown to result in better glycemic control in type II diabetes patients. Obesity and diabetes are states of increased inflammation; exenatide is expected to lead to decreased inflammation by virtue of better…
- Trial name
- NCT01154933
- Testing
- exenatide 5 mcg, exenatide 10 mcg
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University at Buffalo
Obesity
Modifiable Predictors of Neural Vulnerabilities for Obesity
The purpose of this study is to examine patterns of neural activation in a priori selected brain regions associated with reward process during anticipation and delivery of appetizing food stimuli (milkshake sips) among young…
- Trial name
- NCT04522947
- Testing
- Milkshake fMRI
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Morbid Obesity
Laparoscopic Gastric Bypass vs LAP-BAND for Treatment of Morbid Obesity
PURPOSE Obesity is a growing problem in the United States. Severe obesity, known as "morbid obesity", is defined as being 100 pounds in excess of ideal body weight.
- Trial name
- NCT00247377
- Testing
- Gastric bypass surgery, Lap-Band
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- University of California, Irvine
Obesity Associated With Defects in Leptin-melanocortin Pathway
Long Term Extension Trial of Setmelanotide
This was a long-term extension trial to study the safety and tolerability of continued setmelanotide treatment in participants who had completed a previous clinical trial on treatment with setmelanotide for obesity associated…
- Trial name
- NCT03651765
- Testing
- Setmelanotide
- Where
- 27 sites in United States, Canada and 6 more
- Volunteers
- 205 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Obesity
Comparing a Virtual vs. Face to Face Weight Management Program Using Phentermine for Patients With Overweight or Obesity
This study will study the effects associated with the prescription of phentermine in a virtual setting, comparing with prescription of phentermine via a standard face-to-face visit for patients with obesity or overweight.
- Trial name
- NCT04614545
- Testing
- Phentermine 37.5 Mg, Dietary program, Exercise program
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cleveland Clinic
Obesity
Cardiometabolic Disease and Pulmonary Hypertension
This study will investigate if metformin can help people with obesity and high pressures inside their lung blood vessels. Metformin is approved by the U.S.
- Trial name
- NCT03349775
- Testing
- Metformin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Endometrial Cancer
Telehealth-Based Resistance Training Intervention for Endometrial Cancer Survivors
This 2-arm pilot trial will enroll 40 participants to test the feasibility, adherence, and benefits of a home-based strength training intervention for endometrial cancer survivors relative to a wait-listed control group.
- Trial name
- NCT03722030
- Testing
- Baseline Measures, Strength-Training, Mid-point Measures
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Obesity
The Effects of Oxytocin in Obese Adults
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in obese adults, ages 18-45 years old.
- Trial name
- NCT03043053
- Testing
- oxytocin nasal spray
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Massachusetts General Hospital
Obesity
Comparison of Supervised and Unsupervised Physical Activity Programs During a Weight Loss Intervention for Adults
Adults who are overweight or obese are typically prescribed a calorie-restricted diet and physical activity to promote weight loss and improve health.
- Trial name
- REACH (NCT02693132)
- Testing
- Supervised (SUP-PA), Unsupervised (UNSUP-PA), Step-based (STEP)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Hypertension, Diabetes
A Multi-center Trial of IMPaCT CHW Support for Chronically-ill Patients
This is a multi-center randomized controlled trial comparing the effectiveness of community health worker (CHW) vs. usual clinician support in helping chronically-ill patients with low socioeconomic status to improve their health…
- Conditions
- Hypertension, Diabetes, Obesity, Tobacco Dependence
- Trial name
- IMPaCT (NCT02347787)
- Testing
- IMPaCT, Usual care
- Volunteers
- 592 people
- Sponsor
- University of Pennsylvania
Severe Obesity
Enhancing Weight Loss Maintenance With GLP-1RA (BYDUREON™) in Adolescents With Severe Obesity
Long-term weight loss maintenance is seldom achieved by individuals with obesity owing to numerous biological adaptations involving appetite, satiety, and energy expenditure in the post- weight loss setting.
- Trial name
- NCT02496611
- Testing
- Weight loss with pharmacotherapy, Weight loss without pharmacotherapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Lean, Obese
In Vivo Leptin Signaling in Humans After Acute Leptin Administration
The purpose of this research study is to help us to better understand how leptin regulates blood sugar levels. Leptin is a recently discovered hormone, which is made in fat cells.
- Conditions
- Lean, Obese, Obese Diabetics
- Trial name
- NCT01275053
- Testing
- leptin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity, Hypercholesterolemia
Feasibility and Acceptability of a Beverage Intervention for Hispanic Adults
This study aims to 1) assess the feasibility and acceptability of a prescribed beverage intervention in 50 obese Hispanic adults ages 18-64 years over 6 weeks; and 2) assess preliminary effects of the beverage intervention on…
- Conditions
- Obesity, Hypercholesterolemia, Hyperglycemia, Hypertriglyceridemia
- Trial name
- NCT02911753
- Testing
- Mediterranean Lemonade, Green Tea, Flavored Water
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Obesity, Insulin Resistance
Increasing Cure Rate of Hepatitis C Therapy in Obese Hepatitis C Patients
The purpose of this study is to determine whether obese people do not respond to hepatitis C treatment as well as lean people. This research studies whether obese people will show higher sustained virologic response rate if they…
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome, Hepatitis C
- Trial name
- NCT00871845
- Testing
- Dietary and Lifestyle modification educational sessions
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Hossam Kandil
Obesity
Guided Self-help for Families With an Overweight Child
The purpose of this study is to evaluate whether a home based program can teach parents and moderately overweight kids who are of 8-12 years old with a BMI% between 85-97%, how to manage their child's weight.
- Trial name
- GSH (NCT01145833)
- Testing
- Immediate Treatment Group, Delayed Treatment Group
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
PreDiabetes, Obesity
Comparison of Outreach Methods to Encourage Enrollment in Diabetes Prevention and Weight Management Programs
Individuals with prediabetes are at increased risk for developing diabetes. Higher hemoglobin A1c's (6.1-6.4%) are associated with a high risk of developing diabetes.
- Trial name
- NCT03200535
- Testing
- EHR gaps, Bulk outreach, Dietician call
- Where
- United States
- Volunteers
- 6,588 people
- Sponsor
- Kaiser Permanente
Overweight, Obese
Location Initiated Individualized Texts for Adolescent Health (LIITAH)
The goal of this study is to test whether the mobile application (app.) helps adolescents make healthy food choices, decreasing calories purchased from restaurants, fewer number of visits to restaurants, and if it has an impact…
- Conditions
- Overweight, Obese, Healthy
- Trial name
- NCT03762135
- Testing
- Full version of the LIITah App., Partial App. (ELI and SNAP only)
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity, Atherosclerosis
Endothelial Dysfunction in Obese Children
The purpose of this study is to objectify the effect of diet and exercise on early markers of atherosclerosis in obese children.
- Trial name
- EDOC (NCT01461226)
- Testing
- Exercise training, Usual care
- Where
- 3 sites in Belgium
- Volunteers
- 61 people
- Sponsor
- University Hospital, Antwerp
Type 2 Diabetes Mellitus
Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Participants With Type 2 Diabetes
A Phase 2 study Comparing the effects on glucose control of MEDI0382 in combination with Dapagliflozin and Metformin compared to placebo in combination with Dapagliflozin and Metformin in overweight/obese participants with Type 2…
- Trial name
- NCT03444584
- Testing
- MEDI0382, Dapaglifozin, Metformin
- Where
- 8 sites in Germany, Hungary and 1 more
- Volunteers
- 49 people
- Sponsor
- MedImmune LLC
Obesity, Morbid
Positive Psychology Intervention for Patients Post-bariatric Surgery and Their Partners
The goal of this waitlist-control design, pilot randomized controlled trial is to test feasibility, acceptability, and preliminary efficacy of a remotely-delivered dyadic positive psychology intervention for patients 2 years…
- Trial name
- NCT05958615
- Testing
- Reimagining Us in the Context of Bariatric Surgery (ReConnect)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Larissa McGarrity, Ph.D.
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