Clinical trials: Obesity Associated Disorder
Obesity (BMI>30), Neuroinflammation
Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP/NPY and POMC Pathways in Mexican Population With Obesity
This clinical trial will determine whether taking ascorbic acid (vitamin C), α-tocopherol (vitamin E), or both together can lower markers of brain inflammation and change the expression of neuropeptides in Mexican adults with…
- Trial name
- NCT07782411
- Testing
- Ascorbic acid (Vitamin C), tocopherol alpha, Ascorbic acid + tocopherol alpha
- Where
- Mexico
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Autonomous University of Morelos
Diet Habit, Pollution; Exposure
Children's Health Study Diet and Air Pollution
This study is built upon the existing data in the Children's Health Study to examine the longitudinal association between childhood exposure to air pollutants and changes in diet among adolescents.
- Conditions
- Diet Habit, Pollution; Exposure, Child Obesity
- Trial name
- CHS DIET (NCT03379298)
- Volunteers
- 3,142 people, healthy volunteers welcome
- Sponsor
- University of Southern California
MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
Efficacy of 12-week Daytime Restricted Eating on Hepatic Steatosis of Obesity
The objective of this study is to demonstrate that an < or equal to 8-hour time-restricted eating (i.e., fasting for at least 16 hours every day), not focusing on reducing caloric intake, reduces intra-hepatic fat in patients…
- Trial name
- CHRONOSTEATOSI (NCT07378072)
- Testing
- Time Restricted Eating, Usual care only
- Where
- 9 sites in France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Metabolism and Nutrition Disorder, Liver Diseases
The Effect of Vegetarian Diet on Patients With Metabolic Associated Fatty Liver Disease
In this study, 18-60 years old patients with metabolic associated fatty liver disease（MAFLD） will be recruited to test the intervention effect of vegetarian diet.
- Conditions
- Metabolism and Nutrition Disorder, Liver Diseases, Obesity, Diet, Healthy
- Trial name
- NCT05443581
- Testing
- dietary intervention
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD
Chronic kidney disease (CKD) is the progressive damage to kidney function, associated with an increased risk of cardiovascular diseases, such as stroke or myocardial infarct, particularly in the most severe stages of CKD, in…
- Conditions
- Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 1, Chronic Kidney Disease Stage 2
- Trial name
- ADIPO-CKD (NCT07309094)
- Testing
- GLP-1 receptor agonist, SGLT2 inhibitor, Tirzepatide
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Cardenal Herrera University
Physical Inactivity, Obesity
Factors Associated With Physical Inactivity Among Adolescents
Despite the acknowledgment that physical activity is important for health, there are still few population-based or school-based studies that uses the current physical activity guidelines for adolescents.
- Conditions
- Physical Inactivity, Obesity, Overweight
- Trial name
- FAPIA (NCT01137227)
- Where
- Brazil
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Metabolic Dysfunction-associated Steatotic Liver Disease
Advanced Fibrosis Detection for MASLD in Primary Care
This proposal evaluates the implementation of a novel, non-interruptive, electronic health record alert for metabolic dysfunction-associated steatotic liver disease (MASLD) fibrosis risk assessment in primary care patients with…
- Trial name
- NCT07159386
- Testing
- EHR alert
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Medical University of South Carolina
Obesity, Overweight
Low Carbohydrate and Conventional Diets Associated to Resistance Training on Muscle Fitness and Health Markers
The purpose of this study was to compare the effects of two different diets (low carbohydrate - LCD and conventional - CONV) on body composition, strength performance, muscle mass and biomarkers of health in overweight adults…
- Trial name
- LCD-RT (NCT01096836)
- Testing
- macronutrient and energy manipulation
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Gama Filho
Hypertriglyceridemia, Obesity
Setmelanotide in a Single Patient With Partial Lipodystrophy
The objective of this single patient study is to assess the safety and efficacy of setmelanotide as a treatment of severe metabolic abnormalities resulting from LD, especially refractory hypertriglyceridemia leading to recurrent…
- Trial name
- NCT03262610
- Testing
- Setmelanotide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Overweight and Obesity, Inflammation
Prognostic Value of SII and SIRI in Obesity-Related Metabolic Complications
This observational study aims to evaluate the diagnostic and prognostic value of the systemic immune-inflammatory index (SII) and the systemic inflammation response index (SIRI) in individuals with overweight or obesity.
- Conditions
- Overweight and Obesity, Inflammation, Metabolic Syndrome
- Trial name
- SIMO-PRO (NCT07431593)
- Testing
- Nutritional counselling
- Where
- Croatia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Prader-Willi Syndrome
Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injuries Behavior Associated With Prader-Willi Syndrome
This is a placebo-controlled clinical trial to assess the utility of Guanfacine Extended Release (GXR) in the management of patients with Prader Willi Syndrome (PWS) who have significant aggression or self-injury.
- Trial name
- NCT04066088
- Testing
- Guanfacine extended release (GXR)
- Where
- United States
- Sponsor
- NYU Langone Health
Overweight and Obesity, Endothelial Dysfunction
Influence of Walnut Intake on Vascular Function and Metabolism
This study seeks to confirm and extend previous finding that four weeks of daily intake of 40 g of walnuts improve microvascular function, increasing the reactive hyperemia index (RHI), effects which were greatest in individuals…
- Conditions
- Overweight and Obesity, Endothelial Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03900403
- Testing
- Walnut Intake
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis