Clinical trials: Obesity Overweight
Obesity, Overweight
A Study of TG103 Injection in the Management of Non-diabetic Overweight or Obesity
This study is a randomized, double-blind, placebo-controlled, parallel phase 2 study to evaluate efficacy, safety, pharmacokinetic characteristics and immunogenicity of TG103 injection for weight management in non-diabetic…
- Trial name
- NCT06226090
- Testing
- TG103 7.5 mg, TG103 15 mg, TG103 22.5 mg
- Where
- China
- Volunteers
- 314 people
- Sponsor
- CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.
Low Physical Activity Level, Central Obesity
Physical Activity on Prescription in Overweight Older Adults
This randomized controlled study evaluates the effect of individualized physical activity on prescription (PAP) in older overweight adults.
- Conditions
- Low Physical Activity Level, Central Obesity, Metabolic Syndrome
- Trial name
- NCT02320760
- Testing
- Physical activity on prescription
- Volunteers
- 102 people
- Sponsor
- Karolinska Institutet
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hyperlipidemia, Obesity
Metabolic Health Benefits of Dairy Protein
The purpose of this study is to evaluate the effects of regular low fat diary consumption on markers of cardiovascular (CV) and metabolic (cardiometabolic) health including body composition (% body fat, body weight), blood…
- Trial name
- NCT01761955
- Testing
- High Dairy
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Obesity
A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity
Background: Obesity affects 1 in 5 children in the United States. Childhood obesity often persists into adolescence and adulthood.
- Trial name
- NCT07437976
- Testing
- Weight loss intervention, No Weight loss intervention
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Obesity, Postoperative Pain
Laparoscopic Bariatric Surgery and Erector Spinae Plane Block
The aim of the study is to evaluate the effect of erector spinae plane (ESP) block on postoperative analgesic consumption in patients undergoing laparoscopic bariatric surgery
- Conditions
- Obesity, Postoperative Pain, Bariatric Surgery
- Trial name
- NCT04189289
- Testing
- ESP block group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Antalya Training and Research Hospital
Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time
Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery
This is a multicentre, investigator-blinded, randomised controlled trial evaluating whether the use of oral metoclopramide before surgery can reduce the amount of residual gastric content in patients who are taking glucagon-like…
- Conditions
- Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time, Preoperative Risk Assessment, Obesity (Disorder)
- Trial name
- GEM-GLP1RA (NCT07100691)
- Testing
- Metoclopramide
- Where
- 2 sites in Ireland
- Volunteers
- 80 people
- Sponsor
- Mater Misericordiae University Hospital
Obesity, Adolescent, Stress
Ethnic Influences on Stress, Energy Balance and Obesity in Adolescents
The study will examine the mechanisms linking race, stress and biobehavioral factors to energy balance and obesity in both natural and controlled environments in African-American and Caucasian adolescent females.
- Conditions
- Obesity, Adolescent, Stress, Physical Activity
- Trial name
- NCT03369691
- Where
- United States
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Type 2 Diabetes, Overweight
Effects of Replacing Diet Beverages With Water on Weight Loss and Plasma Glucose Control in Type 2 Diabetes
The purpose of the present study is to evaluate the effect of replacing diet beverages with water on weight loss and biochemical indicators for insulin sensitivity and cardiometabolic risk factors of diabetic obese and overweight…
- Conditions
- Type 2 Diabetes, Overweight, Obese
- Trial name
- NCT02412774
- Testing
- DBs at the end of the main meal + Diet, Water at the end of the main meal+ Diet
- Where
- Iran
- Volunteers
- 81 people
- Sponsor
- Novindiet Clinic
Adiposity
Myokine Identification Following Acute Exercise
Exercise stimulates a cascade of responses within the human body. For example, exercise results in the release of proteins into the circulation which communicate with cells and organs throughout the body.
- Trial name
- NCT06223035
- Testing
- Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
OBESITY
The Effect Of Planned Educatıon Based On The Health Improvement Model
The aim of this study is to determine the effect of planned education based on the health promotion model on lifestyle behaviors and weight management in obese secondary school students.
- Trial name
- NCT05577325
- Testing
- control group will be followed without health education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Ayse Yilmaz
Type 2 Diabetes, Overweight or Obesity
Effect of Low-calorie Diets With Different Macronutrient Composition and Macronutrient Distribution in Shift Workers With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
Background and Aims: Shift work, particularly involving night shifts, is associated with increased risk of metabolic disturbances such as type 2 diabetes mellitus (T2DM).
- Conditions
- Type 2 Diabetes, Overweight or Obesity, PreDiabetes
- Trial name
- NCT06912555
- Testing
- Diet
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad de Zaragoza
Obesity
To Investigate the Safety, Tolerability and Pharmacodynamics of GSK2890457 in Healthy Volunteers and Subjects With Type 2 Diabetes
This study is the first administration of GSK2890457 in humans. The study will be conducted in 3 parts: - Part A (conducted at a single investigative site) will determine the safety and tolerability of GSK2890457 alone in healthy…
- Trial name
- NCT01725126
- Testing
- GSK2890457, Metformin, Liraglutide
- Where
- 3 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity
Influence of Carboxypeptidase D (CPD) Gene on Body Weight and Fat Mass Reduction by Perindopril in Obese Subjects
The primary objective of this study is to evaluate the Carboxipeptidase D (CPD) genotyping as a predictive biomarker of body weight and/or fat mass reduction in obese patients treated with perindopril.
- Trial name
- GPD-01-01 (NCT02777489)
- Testing
- Perindopril
- Where
- 13 sites in Portugal
- Volunteers
- 140 people
- Sponsor
- Gene PreDiT
Obesity, Pharmacokinetics
Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations
This study will find how weight affects the dosing of a drug called sulfamethoxazole and trimethoprim. Currently, the amount of sulfamethoxazole and trimethoprim a patient receives is the same regardless of the patient's weight.
- Conditions
- Obesity, Pharmacokinetics, MRSA, Tuberculosis
- Trial name
- NCT01167452
- Testing
- Sulfamethoxazole/trimethoprim
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Gestational Diabetes, Hyperglycemia
Gestational Metabolic Abnormalities and Maternal and Infant Nutrition and Health
Childhood obesity is on the rise and is a major risk factor for type 2 diabetes later in life. Recent evidence indicates that abnormalities that increase risk for diabetes may be initiated early in infancy.
- Conditions
- Gestational Diabetes, Hyperglycemia, Insulin Resistance, Obesity
- Trial name
- NCT01405547
- Where
- Canada
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Anthony Hanley
Obstructive Sleep Apnea, Obesity
Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese
This study evaluates the effectiveness of intraoral appliance in the treatment of obstructive sleep Apnea Syndrome in class III obese in comparison to an adjustable silicone appliance.
- Trial name
- NCT03517150
- Testing
- mandibular advancement device
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Pre-diabetes, Obesity
Vascular Function, Endothelin, and Inflammation in Pre-diabetic Obesity Versus Lean Healthy Controls
Aims: 1. Does inflammation contribute importantly to concurrent defects in vascular and metabolic dysfunction in human pre-diabetic obesity? 2.
- Trial name
- NCT00837590
- Testing
- Chronic salsalate, Acute Salsalate
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity & Overweight
Retrospective Evaluation of Sibutramine-Topiramate Therapy for Obesity in Real-World Outpatient Practice
This retrospective real-world cohort study aims to evaluate the effectiveness, safety, and tolerability of the combination of sibutramine and topiramate in the treatment of obesity and overweight associated with metabolic…
- Trial name
- SIBUTAMATE (NCT07588750)
- Testing
- Sibutramine + Topiramate
- Where
- Brazil
- Volunteers
- 278 people
- Sponsor
- Falquetomed
Obese Patients
Intragastric Balloon for Treatment of Overweight and Obesity: Which is the Best Filling Volume?
TITLE: Randomized study conducted in a single center, with the aim of comparing the three main filling volumes of the intragastric balloon in overweight or obese patients (BMI >27 and <60 kg/m2).
- Trial name
- NCT06673550
- Testing
- Intragastric balloon
- Where
- Italy
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Mater Olbia Hospital
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