Clinical trials: Obesity Overweight
Visceral Obesity, Atherosclerosis
Abdominal Fat and Imaging Measurements of Heart Disease
Although it is frequently mentioned in the media that overweight and obesity have reached epidemic proportions worldwide and in this country, some Canadians are perplexed and sometimes confused about the role of obesity in…
- Conditions
- Visceral Obesity, Atherosclerosis, Metabolic Syndrome
- Trial name
- NCT01447745
- Where
- Canada
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Laval University
Obesity
Safety Follow-up Study of Participants Dosed With INV-347 in Study INV-CL-108
The study looks at the safety and blood levels of the study drug INV-347 in participants who were previously dosed with INV-347 in study INV-CL-108.
- Trial name
- NCT07153172
- Testing
- INV-347
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Obesity, Overweight
Reclaiming Indigenous Food and Health
The overall purpose of this proposed action-research project is to measure the feasibility of consuming and the impact of indigenous plants and foods on health outcomes among Native American participants.
- Conditions
- Obesity, Overweight, Diabetes, Hypertension
- Trial name
- NCT03661177
- Testing
- Sovereign nation diet
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Type 2 Diabetes Mellitus, Insulin Resistance
Anti-Inflammatory Small Drug Adjunctive Therapy for Type 2 Diabetes
The role of individual leukocyte populations in type 2 diabetes (T2D) and immunometabolism in general represent important gaps in knowledge to better understand the etiopathogenesis of T2D.
- Trial name
- NCT02597101
- Testing
- Metformin, saxagliptin, AZD9668
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Nick Giannoukakis, PhD
Overweight, Obesity
Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight
The purpose of this study is to see how oral semaglutide, when taken in lower doses help lowering of body weight in participants with excess body weight when compared to 'dummy' tablets (placebo).
- Trial name
- OASIS 5 (NCT07770841)
- Testing
- Semaglutide
- Where
- 62 sites in United States, Belgium and 8 more
- Volunteers
- 450 people
- Sponsor
- Novo Nordisk A/S
Obesity
Neurohormonal & Behavioral Correlates of Obesity and Weight Loss
Obesity has reached epidemic levels in the United States, and is on the rise in many industrialized nations. The rate of recidivism for long-term weight loss is substantial and presents a critical problem given the importance of…
- Trial name
- NCT02063451
- Testing
- Very Low Calorie Diet (VLCD)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity
Effect of a Very Low-Calorie Ketogenic Diet on Gut Microbiota and Fat Distribution
Short-term interventions that use very low-calorie ketogenic diets and meal replacements may be prescribed for selected overweight or obese patients with type 2 diabetes or prediabetes.
- Trial name
- NCT04019431
- Testing
- Whey protein, vegetable protein or animal protein
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Roma La Sapienza
Metabolic Syndrome, Mental Disorders
Impact of Aerobic Exercise on Metabolic Syndrome, Neurocognition and Empowerment in Individuals With Mental Disorders
This study aims to develop a program of systematic physical exercise maintained for at least 12 weeks to normalize biomarkers of metabolic syndrome; improve neurocognition and social functioning; increase empowerment, self-esteem…
- Trial name
- EXERTMG (NCT02858102)
- Testing
- Physical activity program
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundación Marques de Valdecilla
Obesity, Food Cravings
Food Cravings Strategies During Dietary Weight Loss
The purpose is to optimize the EMPOWER program by integrating strategies to reduce food cravings, a critical yet often overlooked factor for long-term success in weight management.
- Conditions
- Obesity, Food Cravings, Weight Loss
- Trial name
- NCT06280339
- Testing
- Test two food cravings strategies during dietary weight loss, Dietary weight loss program +Food cravings strategies
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Illinois at Urbana-Champaign
Obesity
Methods of Weight Loss in Overweight Coronary Patients
We hypothesize that a combination of high-caloric expenditure exercise and behavioral weight loss counseling would lead to a greater loss of fat mass and a greater improvement in cardiometabolic risk factors that standard (lower…
- Trial name
- NCT00628277
- Testing
- high caloric expenditure exercise, low caloric expenditure exercise plus dietary counseling
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Vermont
Muscle Mass
Strength Training Response of Muscle in GLP-1 Users
GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function.
- Trial name
- STRONG-GLP (NCT07104539)
- Testing
- Strength Training, Wait first, then strength training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Gastroesophageal Reflux
Prevalence, Predictors and Management of Gastroesophageal Reflux After Laparoscopic Sleeve Gastrectomy
From January 2017 to January 2022, we looked at patients who had primary LSG and developed GERD. Before and after surgery, patients for LSG performed barium meal in Trendelenburg position and upper GIT endoscopy.
- Trial name
- LSG-GERD (NCT05416645)
- Testing
- patients with GERD after LSG
- Where
- Egypt
- Volunteers
- 1,537 people
- Sponsor
- Mansoura University
Metabolic Syndrome, Obesity
Body Weight and Vascular Function
An increased body mass impairs vascular function (VF), an important characteristic of subjects suffering from type 2 diabetes and a risk marker for cardiovascular diseases.
- Trial name
- NCT01675401
- Testing
- Weight-loss treatment, No-weight loss treatment
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Bariatric Surgery Candidate
Influence of a Moderate Physical Exercise Program in Health of Patients Underwent Bariatric Surgery in Talca City, Chile
Obesity is a multifactorial disorder resulting from multivariate etiopathogenic factors. The current lifestyle, causes a gradual increase in weight both in the adult population and in the child population.
- Trial name
- NCT03159312
- Testing
- Physical activity based on a moderate exercise program
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Obesity, Bariatric Surgery
Establishment of a Classification System and Postoperative Risk Warning Model for Patients Undergoing Bariatric Metabolic Surgery for Severe Obesity
This study aims to establish a classification system for patients undergoing metabolic surgery for severe obesity by constructing a prospective cohort of 2,000 patients and collecting clinical and biological data at multiple time…
- Conditions
- Obesity, Bariatric Surgery, Bariatric Surgery (Sleeve Gastrectomy )
- Trial name
- NCT07093502
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Prediabetes, Obesity
Healthy Living Partnership to Prevent Diabetes
The Healthy Living Partnership to Prevent Diabetes (HELP PD) is a 300-participant randomized trial designed to test the effectiveness of a lay-health counselor led community-based diabetes prevention program in reducing blood…
- Trial name
- HELP PD (NCT00631345)
- Testing
- Group-Based Lifestyle Intervention (Phases 1 and 2), Individual Education Program (All Phases), Self-Directed Maintenance (Phase 3)
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Morbid Obesity
Accelerated Aging of the Cells of Visceral Adipose Tissue in Morbid Obese Subjects
Numerous epidemiological studies clearly showed the relationship between the excessive growth of visceral adipose tissue and risk of developing insulin resistance, type 2 diabetes and other cardiovascular risk factors.
- Trial name
- SENAPID (NCT01525472)
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
NAFLD
The Role of Microbiome Reprogramming on Liver Fat Accumulation
The purpose of this study is to investigate whether reprogramming the microbiome via soluble fiber supplementation will decrease liver fat in obese individuals.
- Trial name
- MILE (NCT03914495)
- Testing
- Inulin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Childhood Obesity
Childhood Obesity: a Study of Group Treatment Targeting Parents Behaviour
Long term effects of treatment of childhood obesity are not well documented but there is growing evidence that parental involvement and behavioral changes are strong predictors of children weight loss.
- Trial name
- NCT00842777
- Testing
- Parent manualized group treatment, Parent self-help groups
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- Norwegian University of Science and Technology
Overweight, Healthy Participants
IBI3042 Study in Healthy Participants and Overweight or Obese Participants
This is a Phase 1 study of IBI3042, an investigational oral medicine being developed as a potential treatment for overweight and obesity. The study has two parts. Part A will evaluate single doses of IBI3042 in healthy adults.
- Conditions
- Overweight, Healthy Participants, Obesity
- Trial name
- NCT07793019
- Testing
- Orforglipron, IBI3042
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
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