Clinical trials: Obesity and Metabolic Syndrome
Obesity
Bariatric Surgery: Microbiome & Diabetes
This study is a prospective cohort study, following 80 morbidly obese patients undergoing bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB).
- Trial name
- NCT03723486
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Down Syndrome, Alzheimer Disease
Brain Outcomes With Lifestyle Change in Down Syndrome
The goal of this study is to determine if weight loss or changes in dietary intake can help prevent of delay adults with Down syndrome from developing Alzheimer's Disease Adults with Down syndrome without dementia will be…
- Conditions
- Down Syndrome, Alzheimer Disease, Obesity
- Trial name
- BOLD (NCT05985486)
- Testing
- Diet, Health Education
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Kansas Medical Center
Hyperphagia, Prader-Willi Syndrome
Prader-Willi Syndrome and Appetite
Excessive weight gain is a cardinal feature of Prader-Willi syndrome (PWS) for which there is presently no effective treatment. It is caused by increased appetite, decreased perception of satiety and obsessive and compulsive…
- Trial name
- NCT00175305
- Testing
- Sandostatin LAR
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Obesity, Metabolic Syndrome
Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry
There is an ongoing and worsening problem with obesity in the developed, and much of the developing world. Although it has long been realized that Western diets that are rich in sugar and fat play an important role in this, it…
- Trial name
- NCT03138382
- Testing
- Vestibular Nerve Stimulator
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity, Metabolic Syndrome
Strawberry Consumption in Overweight and Obese Individuals
Our proposal represents an integrated approach to determining the cardiovascular and metabolic effects of strawberry consumption in adults who have high risk for cardiometabolic disease.
- Trial name
- NCT04094103
- Testing
- Active strawberry powder, Mixed strawberry powder
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Carl Ade, M.S., Ph.D.
Lung Diseases, Sleep Apnea Syndromes
Sleep Apnea in a Non-Clinical Population
To investigate the causes, consequences and quantitation of sleep disordered breathing (SDB).
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Obesity, Cardiovascular Diseases
- Trial name
- NCT00005551
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Metabolic Syndrome
Salmon Peptide Fraction: Safety and Cardiometabolic Health
The overall goal of this study is to verify the safety of 15g of salmon peptide fraction (SPF), and to test the effects on metabolic syndrome risk factors of two doses of SPF (7.5g and 15g) in overweight-obese men and women.
- Trial name
- SPF1 (NCT05025462)
- Testing
- Supplement dose 15g/d, Supplement dose 7.5g/d
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Laval University
Obesity, Metabolic Syndrome
The Predictive Role of Preoperative Pentraxin-3 (PTX3) in Metabolic and Inflammatory Outcomes After Roux-en-Y Gastric Bypass
This study evaluated the prognostic value of preoperative pentraxin-3 (PTX3) levels in predicting weight loss, inflammatory resolution (CRP, IL-6), and metabolic improvements (HOMA-IR) following Roux-en-Y gastric bypass in…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance, Inflammation
- Trial name
- PTX3-BYPASS (NCT07241741)
- Testing
- Biomarker Stratification by PTX3
- Volunteers
- 23 people
- Sponsor
- Istanbul University
Hypogonadism, Male, Diabetes Mellitus, Type 2
Study on Effects of Testosterone Replacement Therapy in Hypogonadal Type 2 Diabetic Patients" (SETH2)
Aim of the study was to investigate the effects of testosterone replacement therapy on components of metabolic syndrome, vascular function and morphology, grade of non-alcoholic fatty liver disease (NAFLD), bone mineral density…
- Conditions
- Hypogonadism, Male, Diabetes Mellitus, Type 2, Obesity
- Trial name
- SETH2 (NCT03792321)
- Testing
- Testosterone Undecanoate
- Volunteers
- 55 people
- Sponsor
- University Medical Centre Ljubljana
Cardiovascular Disease, Diabetes
Taste Perception and Chronic Disease Risk
The purpose of the Taste Perception Study is to assess variations in the ability to taste and perceive sensations from various stimuli in younger (18-49 years) and older (50-85 years) volunteers.
- Conditions
- Cardiovascular Disease, Diabetes, Obesity, Metabolic Syndrome
- Trial name
- NCT01023906
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tufts University
Type 2 Diabetes
Change of Lifestyle by Persons in Risk of Type 2 Diabetes
We know that changing lifestyle can prevent type 2 diabetes. The challenge is how to help people changing their lifestyle. We have people in 2 groups: half of them is meeting in grops of 10 persons (interventiongroup), the other…
- Trial name
- NCT00202748
- Testing
- Increase in activity to control weight, Increase in activity to control weight.
- Where
- Norway
- Volunteers
- 220 people
- Sponsor
- Sorlandet Hospital HF
Obesity Hypoventilation Syndrome
Obesity Hypoventilation Syndrome Prevalence Study
This is an observational study to characterize the prevalence of Obesity Hypoventilation Syndrome in patients referred to the sleep lab.
- Trial name
- NCT01964339
- Testing
- BMI greater than or equal to 30kg/m2 scheduled for PSG. Undergo blood draw (venous blood gas and metabolic panel) and data collection from PSG study., BMI greater than or equal to 30kg/m2 scheduled for PSG. Undergo blood draw (arterial blood gas and metabolic panel) and data collection from PSG study.
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Philips Respironics
Obesity and Obesity-related Medical Conditions
"F!reF!ghterF!t": Lifestyle Coaching Interventions for Obese Firefighters (FireFit)
Our goal is to explore the effectiveness of 9- month lifestyle medicine based coaching intervention (individual and group coaching) versus control (usual care/ written health instructions).
- Trial name
- FireFit (NCT06890975)
- Testing
- Lifestyle Coaching
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cambridge Health Alliance
WAGR Syndrome, Wilm's Tumor
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions
This study will explore conditions caused by the absence of certain genes on chromosome 11. These conditions include WAGR syndrome, which is characterized by a kidney tumor called Wilm s tumor, aniridia (absence of the iris of…
- Conditions
- WAGR Syndrome, Wilm's Tumor, Aniridia, Urogenital Abnormalities
- Trial name
- NCT00758108
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Metabolic Syndrome
Effect of a Grape Seed Extract (GSE) on Insulin Resistance
In people with the metabolic syndrome, the investigators hypothesize that administration of a single 300 mg dose of a grape seed extract (GSE) will reduce insulin resistance (how well cells in the body can take up and use…
- Trial name
- NCT01889368
- Testing
- Grape Seed Extract
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, Davis
Metabolic Syndrome
A Short Term Evaluation of a Structured Weight Loss Plan in Overweight and Obese Adults
The present study is designed to examine the effect of changes in body weight and related parameters associated with a commercially-available, low-carbohydrate diet plan.
- Trial name
- NCT02774668
- Testing
- "Grab-and-Go" meal plan, "Jump-Start" meal plan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Metabolic Syndrome
Effects of Polyphenols of Pomegranate Fruit Peel Extract on Inflammation and Oxidative Stress in Metabolic Syndrome
The purpose of this study is to evaluate the effects of polyphenols of pomegranate fruit peel extract compared to placebo on oxidative stress and inflammation in overweight and obese subjects with metabolic syndrome.
- Trial name
- NCT05915117
- Testing
- Polyphenols of pomegranate fruit peel extract (PoPex)
- Where
- Bosnia and Herzegovina
- Volunteers
- 60 people
- Sponsor
- University of Banja Luka
Bstructive Sleep Apnea (OSA) and Obesity
A Phase III Study Evaluating the Efficacy and Safety of HRS9531 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity
A Phase III Study Evaluating the Efficacy and Safety of HRS9531 Injection in Subjects with Obstructive Sleep Apnea (OSA) and Obesity
- Trial name
- NCT06974851
- Testing
- HRS9531
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Obesity
The Effects of Oral Glucose Compared to Sweetener Drinking on Hormonal/Metabolic Responses
The goal of this study is to determine the hormonal/metabolic reponse to ingestion of sugar compared to consuming artificial sweetened drink, and to evalute macronutrient consumption 24 hours post ingestion of the drinks.
- Trial name
- NCT01683929
- Testing
- glucose, sweetner
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Diabetes-related Complications
Myocardial Regional Function by Dobutamine Stress Echocardiography in the Metabolic Syndrome and Type 2 Diabetes
Summary. Theoretical Rationale: The left ventricular myocardial performance results from a complex interplay between linear deformations (longitudinal, circumferential and radial) and twist/ untwist mechanics.
- Trial name
- NCT02505451
- Testing
- dobutamine
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Avignon
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