Clinical trials: Obesity in Diabetes
Hyperglycemia
The Association Between Peri-Operative Hyperglycemia and Major Morbidity and Mortality
Surgery induces a stress effect on the body partially through a catabolic energy state. In turn, glucose levels may rise to levels which have been associated with major morbidity (Golden, 1999) and mortality (Ouattara, 2005).
- Trial name
- NCT00487162
- Testing
- intensive glycemic control, conventional glycemic control
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Diabetes Mellitus, Obesity
Glucagon-like Peptide 1 (GLP1) Receptor Agonists and Mental Health
This study is investigating the effect of a medication called glucagon-like peptide 1 (GLP1) receptor agonists on mental health.
- Conditions
- Diabetes Mellitus, Obesity, Mental Health Issue
- Trial name
- NCT05492305
- Testing
- GLP-1 receptor agonist
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College London
Diabetes Mellitus, Type 2, Insulin Resistance
Effects of a Plant-Based Diet on Insulin Requirements and Obesity Markers in Obese Adults With T2DM
This is a crossover study utilizing a Dietary Approaches to Stop Hypertension (DASH) diet and a whole-food, plant-based diet among subjects with type 2 diabetes who require insulin.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Obesity, Nutritional and Metabolic Disease
- Trial name
- NCT04048642
- Testing
- DASH, Whole-Food, Plant-Based
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Rochester
Type 2 Diabetes
Diet With or Without Metarecod® in Obese Subjects With Type 2 Diabetes
Obesity is considered the largest chronic non-communicable disease (globesity) worldwide with a growing trend in the near future.
- Trial name
- MONDO (NCT06813170)
- Testing
- Metarecod, Diet
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obesity
Bariatric Surgery: Microbiome & Diabetes
This study is a prospective cohort study, following 80 morbidly obese patients undergoing bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB).
- Trial name
- NCT03723486
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Metabolic Syndrome, Diabetes
Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens
The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017.
- Conditions
- Metabolic Syndrome, Diabetes, Obesity and Overweight, Hypertension
- Trial name
- NCT07043166
- Where
- China
- Volunteers
- 4,094 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Obesity and Type 2 Diabetes
Investigating Metabolic and Psychological Adaptations in a Clinical Trial
This study aims to explore how food insecurity, a lack of consistent access to enough food, may lead to changes in the body that make it harder to lose weight.
- Trial name
- IMPACT (NCT06800794)
- Testing
- Behavioral Skill Training, Meal Provisioning
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- State University of New York at Buffalo
Diabetes Mellitus, Obesity
Investigating Muscle Failure in Diabetic Myopathy
The goal of this observational study is to assess if diabetes and obesity are independently related to functional and structural muscle deficits, and how muscular deficits relate to metabolic properties of diabetes and obesity.
- Conditions
- Diabetes Mellitus, Obesity, Chronic Hyperglycaemia, Weight Loss
- Trial name
- NCT05685927
- Testing
- 6-months of medically assisted glycemic improvement, Bariatric surgery
- Where
- Denmark
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diabete Type 2
Fetuin-A as a Marker in Obesity and Type 2 Diabetes Mellitus
The aim of this study is to assess the significance of serum fetuin-A as a marker of obesity and type 2 diabetes mellitus. We used multiple statistical approaches to determine that the fetuin-A level is correlated to body mass…
- Trial name
- NCT04218305
- Testing
- Serum Level Of Fetuin A
- Volunteers
- 400 people
- Sponsor
- Minia University
Type 2 Diabetes Mellitus, Obesity
Long Term Free Living Study With Modified Foods and Type 2 Diabetics
Part 1 of this research demonstrated that type II diabetics are lacking in knowledge of how to best treat their illness with dietary controls. Most had little nutrition or diabetes knowledge.
- Trial name
- NCT00198913
- Testing
- lower fat food supplied and education, gift cards for grocery foods and written education
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Type 2 Diabetes Treated With Insulin, Obesity
Dulaglutide Versus Liraglutide in Obese Type 2 Diabetic Adolescents Using Metformin
To compare the efficacy and effect on glycemic control of Dulaglutide versus Liraglutide in obese Type 2 diabetic adolescents using metformin
- Conditions
- Type 2 Diabetes Treated With Insulin, Obesity, Adolescent Obesity
- Trial name
- NCT04829903
- Testing
- Dulaglutide, Liraglutide
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Corporacion Parc Tauli
Diabetes Mellitus, Obesity
Effects of Jeju Red Horsehead Fish-based, High Protein Diet on Satiety and Incretin Hormones in Diabetes Patients
The aim of our study is to investigate the effects of high-protein diet on satiety and incretin hormones in patients with diabetes.
- Trial name
- NCT01678742
- Testing
- High-protein diet, Standard diet
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jeju National University Hospital
Diabetes Mellitus, Type 2, Obesity
"Effectiveness of Supervised and Unsupervised mHealth-based Exercise Interventions on Clinical Outcomes in Adults With Type 2 Diabetes and Obesity Within a Primary Care Context"
Type 2 diabetes (T2D) and obesity are two of the most common chronic conditions worldwide, and they frequently occur together. Both conditions are closely linked to physical inactivity, which is currently recognized as a major…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Insulin Resistance, Sedentary Behaviors
- Trial name
- NCT07685080
- Testing
- Supervised Exercise Training Program, mHealth Unsupervised Exercise Program (ActiVital App), Wearable Device Monitoring (Fitbit Charge 6)
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Escuela Universitaria de Osuna
Lipodystrophy, Obesity
Adipocyte, Insulin-resistance and Immunity : Evaluation of Interleukin-7 in Lipodystrophy, Diabetes and Obesity
White adipose tissue-related diseases spread from excess (obesity) to lack (lipoatrophies) through aberrant distribution (lipodystrophies), these 3 different disorders being paradoxically able to induce a metabolic insulin…
- Conditions
- Lipodystrophy, Obesity, Type 2 Diabetes
- Trial name
- IL-7norm (NCT01784289)
- Where
- 5 sites in France
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Type 2 Diabetes Mellitus
Study To Investigate The Safety And Metabolism Of GSK376501 In Overweight Subjects
This study represents the second Phase 1 study with GSK376501 and the goal is to further evaluate its safety and tolerability. The way the human body processes GSK376501 will also be determined.
- Trial name
- NCT00495014
- Testing
- GSK376501
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity, Weight Loss
Obesity Treatment With a Very Low Energy Diet in Mexican Adults
Clinical practice guidelines recommend behavioral change protocols for obesity treatment, such as the Diabetes Prevention Program, which involves a low-energy diet, physical activity recommendations, behavioral therapy, and…
- Trial name
- NCT05631535
- Testing
- Intensive lifestyle change program with a very-low-energy diet, Intensive lifestyle change program with a low-energy diet
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Universidad de Sonora
Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor
Early Add-On Combination of GLP-1 Receptor Agonist and SGLT2 Inhibitor in People With Cardiovascular-Kidney-Metabolic Stage 2-3
This retrospective observational target-trial emulation uses electronic health record data from the TriNetX US Collaborative Network to compare early treatment intensification strategies in adults with obesity, type 2 diabetes…
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor, Kidney Disease, Type 2 Diabetes
- Trial name
- GLP1-SGLT2-CKM (NCT07465926)
- Testing
- GLP-1 receptor agonist, SGLT2 inhibitor
- Volunteers
- 451,036 people
- Sponsor
- Chung Shan Medical University
Obesity (Disorder), GLP-1 Receptor Agonist Treatment
Probiotics in Obese Patients Treated With Semaglutide
This randomized, double-blind, placebo-controlled trial evaluated the effects of a four-strain probiotic formulation in adults with obesity receiving semaglutide.
- Conditions
- Obesity (Disorder), GLP-1 Receptor Agonist Treatment, Probiotic Intervention, Diabetes Mellitus Type 2
- Trial name
- ProSem (NCT07847593)
- Testing
- Four-strain probiotic formulation
- Where
- 3 sites in Poland
- Volunteers
- 102 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Metabolic Syndrome, PreDiabetes
Exercise, Sleep Quality and Nocturnal Fat Oxidation in Metabolic Syndrome
The purpose of the Exerci-Zzz Study is to learn more about how the time of day that exercise is performed influences sleep quality and fat metabolism overnight in adults with metabolic syndrome.
- Conditions
- Metabolic Syndrome, PreDiabetes, Hypertension, Obesity
- Trial name
- ExerciZzz (NCT04105218)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Cardiovascular Diseases, Hypercholesterolemia
Plant Sterols on Cardiovascular Markers, Microbiota and Sterol Metabolism (Cardiofoodsterol)
Potential cholesterol-lowering effect of a regular intake of a plant sterol (PS)-containing food supplement, in overweight/obese type 1 or 2, normoglycemic/pre-diabetic, with LDL-cholesterol values > 115 mg/dl and not…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Prediabetic State, Overweight and Obesity
- Trial name
- NCT06481020
- Testing
- Plant sterols 2g/day
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- University of Valencia
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