Clinical trials: Obesity in Diabetes
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH)
How Abnormal Function of Fat Tissue in Type 1 Diabetes Contributes to Fat in the Liver
Steatotic liver disease associated with metabolic dysfunction (MASLD) is a disease caused by excess fat storage in the liver. Excessive fat delivery to the liver and MASLD typically occurs in people with abdominal obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH), Type 1 Diabetes Mellitus
- Trial name
- AGL14 (NCT07133854)
- Testing
- Imaging PET/MRI, Stable isotope infusions, meal test
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus Type 2 in Obese
Early Glycaemic Control in Type 2 Diabetes Patients After Bariatric Surgery; ECODABS
Describe and characterize the time-course for improvement in glucose control after bariatric surgery in obese patients with type 2 diabetes Compare these changes in glycemic control after different techniques for bariatric surgery
- Trial name
- NCT04314427
- Testing
- Roux-en-Y gastric bypass, Sleeve gastrectomy
- Where
- 8 sites in Belgium, Spain and 2 more
- Volunteers
- 33 people
- Sponsor
- Sahlgrenska University Hospital
Hypertension, Type 2 Diabetes Mellitus
Nanshan Elderly Cohort Study
Objective: The Nanshan Elderly Cohort Study (NECS) aims to investigate the nutritional, as well as other environmental and genetic factors of chronic diseases, such as cardio-metabolic diseases.
- Conditions
- Hypertension, Type 2 Diabetes Mellitus, Cardiovascular Diseases, Stroke
- Trial name
- NECS (NCT03569735)
- Where
- 2 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Type 2 Diabetes Mellitus
Study of Immune Cells in Obese Patients With Type 2 Diabetes Mellitus Treated With Liraglutide
The purpose of this study is to determine the effect of exogenous glucagon-like peptide-1 on the immune system i.e on the regulation of immune cells important in diseases such as obesity and diabetes.
- Trial name
- NCT02201550
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Hvidovre University Hospital
Type 2 Diabetes, Obesity
Post Marketing Study in Subjects Who Have Type 2 Diabetes Using the EndoBarrier™ Gastrointestinal Liner
The purpose of this study is to evaluate EndoBarrier Gastrointestinal Liner in the post marketing environment in subjects who are obese and have Type 2 Diabetes.
- Trial name
- NCT01114438
- Testing
- EndoBarrier Gastrointestinal Liner
- Where
- 3 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- Morphic Medical Inc.
Obesity, Obesity (Body Mass Index >30 kg/m2)
ENLIGHT Trial: ESG With Fundal Mucosal Ablation
The ENLIGHT Trial is a single-center, randomized controlled trial evaluating whether adding fundal mucosal ablation (FMA) to endoscopic sleeve gastroplasty (ESG) improves weight loss and metabolic outcomes in adults with obesity.
- Trial name
- NCT07792226
- Testing
- Endoscopic Sleeve Gastroplasty (ESG), Fundal Mucosal Ablation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- West Virginia University
Heart Failure, Coronary Artery Disease
COVID-19 Testing in Underserved and Vulnerable Populations
As part of National Institutes of Health Rapid Acceleration of Diagnostics-Underserved Populations (RADx-UP) program, the goal of the RADxUP study is to develop, test, and evaluate a rapid, scalable capacity building project to…
- Conditions
- Heart Failure, Coronary Artery Disease, Cancer, Chronic Kidney Diseases
- Trial name
- NCT05315908
- Testing
- Community outreach method
- Where
- United States
- Volunteers
- 9,120 people
- Sponsor
- Jesse Nodora
Type 2 Diabetes Mellitus, Obesity
Vitamin D Status and Lipid Profile in Obese Adults With Type 2 Diabetes
This prospective, single-center, cross-sectional observational study aims to evaluate the association between serum 25-hydroxyvitamin D concentrations and lipid profile parameters among adults with obesity and established type 2…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Dyslipidemia, Vitamin D Deficiency
- Trial name
- VILD-T2D (NCT07729553)
- Volunteers
- 150 people
- Sponsor
- Sinai University
Type 2 Diabetes, Obesity
Endobarrier Treatment in Obese Subjects With T2DM
Diabesity (Diabetes accompanied by obesity) is a prevalent condition many times complicated by micro- and macrovascular disease. Many treatments for Diabesity paradoxically cause further weight gain and hypoglycemia.
- Trial name
- NCT01718457
- Testing
- Endobarrier
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Sheba Medical Center
Diabetes Mellitus Type 2 in Obese
Cochlear-Vestibular Ganglion (CVG) in Newly Diagnosed Type 2 Diabetes Patients
The proposed study is an integrative scientific undertaking, reflecting the input of experts in the behavioral sciences, mHealth technology, computational biology, endocrinology, biochemistry, and nutrition.
- Trial name
- NCT02668328
- Testing
- Social Cognitive Theory Tailored Behavioral Intervention
- Sponsor
- NYU Langone Health
Diabetes, Environmental Enteropathy
Enteropathy and Diabetes in HIV Patients
Emerging data suggest that HIV-infected people have disproportionately higher risk of diabetes than HIV-uninfected people. Multiple factors may contribute to elevated diabetes risk including increased prevalence of conventional…
- Conditions
- Diabetes, Environmental Enteropathy, HIV
- Trial name
- REEHAD (NCT03713502)
- Where
- Tanzania
- Volunteers
- 1,947 people
- Sponsor
- National Institute for Medical Research, Tanzania
Type 2 Diabetes, High Blood Pressure
Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients
Evaluation of safety, tolerability and superiority of RK-01, a valsartan plus celecoxib dual add-on to metformin-HCL XR over metformin in newly diagnosed and obese adult type 2 diabetes patients with high blood pressure…
- Conditions
- Type 2 Diabetes, High Blood Pressure, Arthritis, Obesity
- Trial name
- RESILIENCE (NCT03686657)
- Testing
- Metformin, Val, Cel and Met XR Low, Val, Cel and Met XR High
- Where
- United States
- Sponsor
- ARKAY Therapeutics
Diabetes Mellitus, Exercise
Exercise as Cardio Protective Modulates in Diabetic Patients
Physical exercise for 6 months produced significant improvement in adiponectin, hs-CRP, and nitric oxide (NO) and was significantly correlated with adiposity markers, lipid profile and glycemic control factors in both obese and…
- Trial name
- NCT03925519
- Testing
- Supervised aerobic exercise
- Volunteers
- 50 people
- Sponsor
- King Saud University
Type 1 Diabetes, Type 1 Diabetes Mellitus
A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
This research study is testing whether a weekly medication called tirzepatide can help adults with type 1 diabetes use their insulin pump more easily, specifically by reducing or eliminating the need to count carbohydrates at…
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus, T1D, T1DM
- Trial name
- TZP (NCT07284511)
- Testing
- Tirzepatide, Tandem Control-IQ Automated Insulin Delivery System (with Dexcom G7 CGM), Carbohydrate Counting
- Where
- 4 sites in Canada, Switzerland
- Volunteers
- 105 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes
A Study of TG103 Injection in Overweight/Obese Subjects Without Diabetes
The main purpose of this study is to assess the safety and tolerability of multiple doses of TG103 injection in overweight/obese subjects without diabetes
- Trial name
- NCT04855292
- Testing
- TG103 injection
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.
Pre-diabetes, Obesity
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further…
- Trial name
- NCT05051436
- Testing
- Mirabegron 50 MG, Tadalafil 10 MG
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Bariatric Surgeries
Food and Gastrointestinal Habits After Bariatric Surgery
The worldwide epidemic of overweight and obesity affects about 1.7 billion people around the world. Since 1991, many international medical societies have established as recommendation for bariatric surgery the unsuccessful…
- Trial name
- NCT01224054
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Campinas, Brazil
Diabetes Prevention, Obesity Prevention
Effects of Intact and Hydrolyzed Pea Protein on Food Intake, Glycemic Response and Subjective Appetite
The purpose of this protocol is to study the effects of intact and hydrolyzed yellow pea protein, compared to intact and hydrolyzed whey protein, on satiety, food intake, and glucose metabolism in healthy young men.
- Trial name
- NCT01298154
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity, Overweight
Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
The primary objective of the study is to determine the effects of ribupatide (KAI-9531) subcutaneous (SC) injection once weekly compared to placebo on percent change in body weight.
- Trial name
- KaiNETIC-1 (NCT07284875)
- Testing
- Ribupatide
- Where
- 110 sites in United States, Argentina and 8 more
- Volunteers
- 2,530 people
- Sponsor
- Kailera
Type 2 Diabetes Mellitus, Obesity
Injectable Semaglutide vs Dulaglutide in Individuals at Cardiovascular Risk
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Overweight
- Trial name
- NCT07619495
- Testing
- Semaglutide, Dulaglutide
- Where
- United States
- Volunteers
- 120,000 people
- Sponsor
- Brigham and Women's Hospital
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