Clinical trials: Obesity in Diabetes
Obesity, Type 2 Diabetes Mellitus
The Heat Study: 2 Year Lifestyle Intervention in Overweight Women to Encourage Weight Management
The purpose of this trial is to determine the most cost effective programme for overweight and obese individuals to maintain weight loss over a 2 year period.
- Trial name
- NCT00128336
- Testing
- Lifestyle: diet and exercise intervention
- Where
- New Zealand
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Otago
Gestational Diabetes, Obesity
Diabetes Prevention Strategies in Women With Gestational Diabetes Mellitus (GDM)
The main goal of this study is to examine the comparative effectiveness of diabetes prevention strategies in women with Gestational Diabetes Mellitus (GDM) on the control of the following conditions: obesity, hyperglycemia…
- Trial name
- NCT01344278
- Testing
- Lifestyle Counseling
- Where
- United States
- Volunteers
- 2,480 people
- Sponsor
- Kaiser Permanente
Type 2 Diabetes, Obesity
Evaluation of the Tantalus System in Type 2 Diabetic Subjects
Metacure MC PT TAN2005-013 feasibility study is a prospective, multi-center, study to evaluate the safety and functionality of the TANTALUS System, in the treatment of obese T2DM patients, and to assess the effect of GCT …
- Trial name
- NCT00276471
- Testing
- Implantable pulse generator and electrodes
- Where
- Austria
- Volunteers
- 18 people
- Sponsor
- MetaCure Limited
Obesity, Pre-Diabetes
Effect of Food Order on Postprandial Glucose Excursions in Pre-Diabetes
The natural history of type 2 diabetes commonly follows a pattern of postprandial dysregulation followed by fasting hyperglycemia leading to overt type 2 diabetes.
- Trial name
- NCT03536364
- Testing
- Food Order, Carbohydrate Last, Vegetables first
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Weill Medical College of Cornell University
Morbid Obesity
Laparoscopic Gastric Bypass Versus Sleeve Gastrectomy to Treat Morbid Obesity
Bariatric surgery in the treatment of morbid obesity is associated with long-term weight-loss and decreased overall mortality. Long-term results have been reported for laparoscopic gastric bypass procedures but the long-term…
- Trial name
- SLEEVEPASS (NCT00793143)
- Where
- 4 sites in Finland
- Volunteers
- 240 people
- Sponsor
- Turku University Hospital
Obesity
Compare Effects of a Soluble Fiber on Weight and Blood Cholesterol
Obesity and type 2 diabetes have clearly been linked together and identified as epidemics in much of the developed world. Historically several different dietary fibers have been used as means of reducing body weight and the…
- Trial name
- NCT00682916
- Testing
- Y288
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Diabetes, Hypercholesterolaemia
The Effect of Providing Genetic Risk Information on Lifestyle Behaviors in African Americans
Cardiovascular disease (CVD) is a major and persistent health disparity for African Americans. Linking GAINS is a randomized pilot and feasibility study designed to evaluate whether receiving genetic risk information early in a…
- Conditions
- Diabetes, Hypercholesterolaemia, Hypertension, Obesity Type 2 Diabetes Mellitus
- Trial name
- LINKING GAINS (NCT07833384)
- Testing
- Color Genomics Genetic Testing Panels
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Metabolic Syndrome
Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome
Background. The prevalence of type 2 diabetes mellitus (T2D) in the world is constantly increasing. Treatment of T2D is complicated by arterial hypertension and obesity (metabolic syndrome - MS).
- Trial name
- NCT06410352
- Testing
- Semaglutide, Empagliflozin, Minigastric bypass, Analimentary detoxication
- Where
- Kazakhstan
- Volunteers
- 220 people
- Sponsor
- University Medical Center, Kazakhstan
Diabetes Mellitus, Obesity
Exercise to Reduce Obesity in Spinal Cord Injury
The purpose of this proposal was to evaluate and compare the health benefits of using upper extremity exercise versus functional electrical stimulation for lower extremity exercise.
- Conditions
- Diabetes Mellitus, Obesity, Paraplegia, Quadriplegia
- Trial name
- NCT00270855
- Testing
- Arm Crank Ergometry, FES Cycle Ergometer
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes, Obese
Postprandial Metabolism After Bariatric Surgery in Type 2 Diabetes
Bariatric surgery procedures have now been firmly demonstrated to lead to significant improvement and even, in many cases, complete reversal of abnormal glucose homeostasis in type 2 diabetes (T2D).
- Trial name
- CB4 (NCT02815943)
- Testing
- biliopancreatic diversion with duodenal switch, sleeve gastrectomy, liquid meal
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Prediabetes, Obesity (Body Mass Index >30 kg/m2)
Behavioral Approach for Latinas Addressing Nutrition, Cravings, and Eating Patterns to Prevent Type 2 Diabetes
Adapt the Regulation of Cues (ROC) treatment program for Latinas to see if it can treat prediabetes and prevent developing of Type 2 Diabetes and reduce weight.
- Trial name
- BALANCE (NCT07478263)
- Testing
- Regulation of Cues
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Type 2 Diabetes, Morbid Obesity
The Effect of a Gastric Bypass on Type 2 Diabetes in the Morbidly Obese Patient
Proof of concept, of RYGBP and its capabilities to cure type 2 diabetes (DM 2) and sleep apnea has already been recognized in the reports on weight loss surgery.
- Trial name
- NCT01086111
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Gasthuisberg
Obesity, Pre-diabetes
The Effect of Time-Restricted Eating in Cardiometabolic Health
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day.
- Trial name
- NCT04484987
- Testing
- 9 hours daily eating window, 15 hours daily eating window
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, Davis
Cognitive Impairment, Dementia
Determinants of Cognitive Impairment Among Geriatrics
This study aims to explore the determinants of cognitive impairment among Indonesian geriatrics in an Old Age Home.
- Conditions
- Cognitive Impairment, Dementia, Hearing Impairment, Vision Impairment and Blindness
- Trial name
- NCT03669536
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Overweight and Obesity
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
AZD9550, previously being developed for the treatment NASH, is a dual GCG and GLP-1 receptor agonist. AZD9550 is now being developed in combination with AZD6234, a SARA, for the treatment of overweight and obesity and its…
- Trial name
- CONTEMPO (NCT06151964)
- Testing
- AZD9550, AZD9550 and AZD6234
- Where
- 15 sites in Austria, Canada and 3 more
- Volunteers
- 166 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2, Obesity
NEW DAY: Nutrition, Exercise, Weight Loss, Diabetes And You
This clinical trial examines whether the addition of individual sessions of a motivational intervention to a state-of-the art behavioral group weight loss intervention for overweight women with Type 2 diabetes improves the weight…
- Trial name
- NCT00007800
- Testing
- Behavioral Group Weight Loss Intervention, Motivational Interviewing
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Diabetes
The Effects of Carbohydrate Source on Food Intake, Blood Glucose and Gut Hormone Response in Healthy Children
This study will compare the effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children.
- Trial name
- NCT02499107
- Testing
- Rice treatment, Pasta treatment, Boiled and mashed potato treatment
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes, Obesity
Registry Observing EndoBarrier® Treatment Outcomes in Subjects With Type 2 Diabetes and/or Obesity
The purpose of the registry was to observe the safety and effectiveness outcomes for subjects treated with the EndoBarrier in the post market setting where the product had Conformité Européene (CE mark) regulatory approval and in…
- Trial name
- NCT03072901
- Testing
- EndoBarrier Gastrointestinal Liner
- Volunteers
- 244 people
- Sponsor
- Morphic Medical Inc.
Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic
A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a common and serious complication of obesity and type 2 diabetes (T2D). HFpEF occurs when the heart muscle unable to relax efficiently to pump the blood around the body.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic, Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
- Trial name
- AMEND (NCT05887271)
- Testing
- Low calorie meal replacement plan, Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Leicester
Metformin, Obesity, Abdominal
Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus
The purpose of this study is to analyze the effects of GLP-1RA on blood glucose, body weight, glucose and lipid metabolism and fat distribution in overweight/obese patients with type 2 diabetes mellitus.
- Conditions
- Metformin, Obesity, Abdominal, Diabetes Mellitus, Type 2, Abdominal Fat
- Trial name
- NCT05779644
- Testing
- Liraglutide, Semaglutide, Metformin
- Where
- China
- Volunteers
- 300 people
- Sponsor
- RenJi Hospital
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