Clinical trials: Obesity in Diabetes
Healthy Participants
A Study to Investigate the Impact of Multiple Doses of Itraconazole on AZD5004 in Healthy Participants and Multiple Doses of AZD5004 on Combined Oral Ethinyl Oestradiol and Levonorgestrel in Healthy Female Participants
The purpose of this study is to assess the impact of multiple doses of itraconazole on the pharmacokinetics (PK) of AZD5004 in healthy participants (Part A), and to assess the impact of multiple doses of AZD5004 on the PK of…
- Trial name
- NCT06942936
- Testing
- AZD5004, Itraconazole, EE/LNG
- Where
- 2 sites in United States, Germany
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypertension (HTN), Diabetes (DM)
Team-Based Shared Decision-Making Program in Cardiovascular-Kidney-Metabolic Health (Healthy Heart - CKM)
The investigators are proposing a new team-based shared decision-making (SDM) program. The goal of this study is to see whether this program is practical and whether it may help adults with cardiometabolic risk factors and…
- Conditions
- Hypertension (HTN), Diabetes (DM), Hyperlipidaemia, Kidney Disease
- Trial name
- SDM in CKM (NCT07662616)
- Testing
- Team-based shared decision-making
- Volunteers
- 94 people
- Sponsor
- Johns Hopkins University
Prediabetes, Obesity & Overweight
Crocus Sativus Tepals Water Extract in Obesity and Prediabetes
The goal of this clinical trial is to determine the acute effects of ingestion of a cold aqueous extract of Crocus sativus tepals on postprandial glycemia and other indicators of metabolic health in patients with obesity and/or…
- Trial name
- ZAFRAN (NCT07261475)
- Testing
- Crocus sativus tepals cold aqueous extract, cold water
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University of Primorska
Healthy Participants
A Study to Investigate the Effect of Elecoglipron on Rosuvastatin and Atorvastatin in Healthy Participants
The study has 2 groups, one each focusing on co-administration of elecoglipron and atorvastatin or rosuvastatin to assess the pharmacokinetics (PK) of atorvastatin in healthy participants.
- Trial name
- NCT07534592
- Testing
- Elecoglipron, Atorvastatin, Rosuvastatin
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Diabete Type 2, Obese
The Effect of Different Starches of Boba Pearls and Sugar Substitutes Used in Milk Tea on Glycaemia, Insulinaemia and Appetite Control (Pearl Study)
The first objective is to investigate the effect of boba pearls made from different starches on glycaemia, insulinaemia and appetite control.
- Trial name
- NCT04115657
- Testing
- Starch 1, Starch 2, Starch 3
- Where
- Singapore
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Childhood Obesity, Prediabetes
Clinical Utility of SUDOSCAN in the Pediatric Population
The main purpose of this study is to evaluate whether SUDOSCAN is a valid, accurate clinical device for the the determination of sweat gland function in the pediatric population.
- Conditions
- Childhood Obesity, Prediabetes, Diabetes
- Trial name
- NCT02216201
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Impeto Medical
Hyperglycemia, Pregnancy
The Extension of HAPO Follow-up Study
The prevalence of diabetes mellitus (DM) and cardiovascular disease (CVD) escalate remarkably worldwide and obesity becomes an epidemic disease.
- Conditions
- Hyperglycemia, Pregnancy, Overnutrition, Maternal Obesity During Childbirth
- Trial name
- NCT05477511
- Where
- Hong Kong
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obesity, Nonalcoholic Fatty Liver
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity.
- Conditions
- Obesity, Nonalcoholic Fatty Liver, Diabetes Type 2, Healthy
- Trial name
- ATM (NCT06335771)
- Testing
- Dietary consultation weight loss intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Type 2 Diabetes Mellitus, Overweight
Diacerein on Insulin Secretion in Diabetes
Aim. To assess the effect of interleukin 1β (IL-1β) and tumor necrosis factor α (TNFα) inhibition with diacerein administration on insulin secretion and metabolic control of drug-naïve patients with type 2 diabetes mellitus…
- Conditions
- Type 2 Diabetes Mellitus, Overweight, Obesity
- Trial name
- NCT01298882
- Testing
- Diacerein
- Where
- Mexico
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Abdominal Obesity, Physical Activity
Physical Activity in Overweight Girls: Implications for Reversing Risk Factors for Type 2 Diabetes
In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, ectopic fat in the liver…
- Trial name
- NCT01323088
- Testing
- Control, Resistance Exercise, Aerobic exercise
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Overweight, Obesity
Effect of Consuming Beans for One Month on Blood Lipids, Satiety, Intake Regulation and Body Weight
This project investigates the effect of regular consumption of commercially available processed white beans (5 cups per week) on food intake, body weight, blood pressure, satiety hormones and glycemic response over a 4-week…
- Conditions
- Overweight, Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00741923
- Testing
- navy beans added to regular diet
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Toronto
Diabetes Mellitus, Obesity
Multinational Point Prevalence Study on the Management of Diabesity in Hospitals
Diabetes related to obesity ("diabesity") is becoming increasingly prevalent. Hospitalizations among people with diabetes are frequent and glycaemic control is often suboptimal during these stays.
- Trial name
- DiabesityDay (NCT06680674)
- Testing
- Routine care for people with diabetes, with or without obesity, in the hospital setting
- Where
- 8 sites in Austria, Czechia and 6 more
- Volunteers
- 207 people
- Sponsor
- Medical University of Vienna
Obesity, Type 2 Diabetes
Magnetic Jejuno-Ileal Diversion Study ("MJI Study")
The purpose of this clinical research study is to evaluate the feasibility/performance, safety and initial efficacy of the GT Metabolic Solutions DI Biofragmentable Magnetic Anastomosis System (Magnet System, DI Biofragmentable…
- Trial name
- NCT06232746
- Testing
- Magnet System, DI Biofragmentable
- Where
- Czechia
- Volunteers
- 9 people
- Sponsor
- GT Metabolic Solutions, Inc.
Type 2 Diabetes
A Feasibility Study of Optimal Non-Pharmacological Lifestyle Modifications in People With Type 2 Diabetes
The overall aim of this study is to examine the feasibility of a 12-month, two-arm lifestyle intervention to induce and maintain remission of type 2 diabetes (T2D).
- Trial name
- ON LiMiT (NCT07262788)
- Testing
- CH-rich diet with exercise, CH-reduced diet with exercise
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes, Obesity
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
The main purpose of this study is to find out how well and how safely tirzepatide works long-term in adults who have type 1 diabetes and obesity or overweight. Participation in the study will last about 20 months.
- Conditions
- Type 1 Diabetes, Obesity, Overweight
- Trial name
- SURPASS-T1D-2 (NCT06962280)
- Testing
- Tirzepatide
- Where
- 79 sites in United States, Argentina and 8 more
- Volunteers
- 465 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis, Type 2 Diabetes
Effects of Acetyl L-Carnitine Supplementation on Clinical, Metabolic and Inflammatory Symptoms in Obese, Diabetic, Postmenopausal Women With Osteoarthritis
OA is a degenerative bone disease more common in postmenopausal women. Diabetes and obesity are common risk factors for the development of OA.
- Conditions
- Osteoarthritis, Type 2 Diabetes, Obesity
- Trial name
- NCT07660081
- Testing
- Acetyl-l-carnitine
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Diabetes Mellitus, Exercise
Exercise as Cardio Protective Modulates in Diabetic Patients
Physical exercise for 6 months produced significant improvement in adiponectin, hs-CRP, and nitric oxide (NO) and was significantly correlated with adiposity markers, lipid profile and glycemic control factors in both obese and…
- Trial name
- NCT03925519
- Testing
- Supervised aerobic exercise
- Volunteers
- 50 people
- Sponsor
- King Saud University
Cardiovascular Diseases, Obesity, Maternal
Advancing Health Equity by Integrating Social-Clinical Models During Pregnancy
This study is being done to find out if online referrals to a food management program for Women, Infants, and Children (WIC) made by clinical teams will get more people to enroll in WIC.
- Conditions
- Cardiovascular Diseases, Obesity, Maternal, Diabetes
- Trial name
- FIMPreg (NCT06311799)
- Testing
- WIC Referral, RDN Referral
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Geisinger Clinic
Metabolic Syndrome, Diabetes Mellitus
Biomarkers Derived From Adipose Tissue Useful for Diagnosis and Prognosis of Cardiovascular Risk (CVR) in Obese Patient
This study evaluates the relationship between the adipose tissue, as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.
- Conditions
- Metabolic Syndrome, Diabetes Mellitus, Inflammatory Response
- Trial name
- CROP (NCT03561987)
- Testing
- Bariatric surgery
- Volunteers
- 70 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Type 2 Diabetes Mellitus, Obesity
Soluble Dietary Fibres in the Prevention of Type 2 Diabetes Mellitus
Controlling the glycemic impact of foodstuffs (by reducing the glycemic load of the diet by using soluble dietary fibres) may reduce the glycemic or insulinemic response.
- Trial name
- NCT01163006
- Testing
- Polydextrose and soluble gluco fibre
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
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