Clinical trials: Obesity in Diabetes
Epicardial Fat
Semaglutide vs Dulaglutide on Epicardial Adipose Tissue
Epicardial Fat (EAT), the visceral fat depot of the heart, is a modifiable cardio-metabolic risk factor and therapeutic target. EAT expresses GLP-1 receptors (GLP-1R).
- Trial name
- NCT04200625
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Miami
Maternal Obesity Complicating Pregnancy, Birth,or Puerperium, Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled
Pregnancy Complications in Women With BMI>25 kg/m2 Enrolled in a Healthy Lifestyle and Eating Habits Program
The investigators evaluate if changing eating habits and introducing a correct lifestyle in women with BMI >25 Kg/m2 would improve unfavorable maternal-fetal outcomes associated with excessive weight gain (EWG) during pregnancy.
- Conditions
- Maternal Obesity Complicating Pregnancy, Birth,or Puerperium, Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled, Exercise Addiction, High-Risk Pregnancy
- Trial name
- TLC (NCT01783210)
- Testing
- Specific Therapeutic Lifestyle Changes program in pregnancy, Dietary and behavioral counselling in pregnancy
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Chronic Disease
Multiple Chronic Conditions for Older Adults
Multiple chronic conditions are common and expensive among patients aged ≥65 and are associated with lower quality of life, poorer response to treatment, worse medical and psychiatric outcomes, higher mortality, and higher costs…
- Trial name
- NCT03387735
- Testing
- Treatment as usual (TAU) + Internet, TAU + ElderTree
- Where
- United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Type 2 Diabetes, Obesity
EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial
This is a pragmatic, 24 month, single-center, randomized, open-label, parallel-group trial comparing an obesity-centric approach with a medically-supervised and comprehensive weight loss program (Cleveland Clinic's Endocrinology…
- Trial name
- EMPOWER-T2D (NCT04531176)
- Testing
- Weight Management Program (WMP), Traditional care, Phentermine / Topiramate Extended Release Oral Capsule
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- The Cleveland Clinic
Obesity, Type 2 Diabetes
Prevalence of Carbohydrate Intolerance in Lean and Overweight/Obese Children
The purpose of this study is to determine the prevalence of impaired glucose (carbohydrate) tolerance in lean children with a family history of diabetes and in overweight/obese children with or without a family history of…
- Trial name
- NCT01967849
- Testing
- Oral Glucose tolerance test
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity, Overweight
A Study of Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Participants With Obesity or Overweight With Type 2 Diabetes
The main purpose of this study is to see how well and how safely bimagrumab, tirzepatide, and the combination, work in lowering body weight in participants with obesity or overweight and type 2 diabetes.
- Trial name
- NCT06901349
- Testing
- Bimagrumab, Tirzepatide
- Where
- 50 sites in United States, Argentina and 3 more
- Sponsor
- Eli Lilly and Company
Obesity, Overweight, T2DM (Type 2 Diabetes Mellitus)
Pharmacokinetics, Safety, and Tolerability of DA-302168S Tablets in Participants With Hepatic Impairment and Normal Hepatic Function
This is an open-label, non-randomized study to assess how DA-302168S is absorbed, distributed, metabolized, and eliminated after a single oral dose.
- Trial name
- NCT07877038
- Testing
- DA-302168S
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chendu DIAO Pharmaceutical Group CO., LTD.
Diabetes Mellitus, Type 2, Nutrition Disorders
Comparison of a Plant Protein Diet to a Animal Protein Diet Emphasized in Type 2 Diabetics
This 6-week parallel randomised prospective dietary intervention study with type 2 Diabetes investigates the nutrition influence of animal protein in comparison to plant protein on the glucose metabolism.
- Conditions
- Diabetes Mellitus, Type 2, Nutrition Disorders, Obesity, Body Weight
- Trial name
- LeguAN (NCT02402985)
- Testing
- High animal protein diet group, High plant protein diet group
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- German Institute of Human Nutrition
Diabetes Mellitus, Type 2, Insulin Resistance
The Acute T-Rex (Timing of Resistance Exercise) Study
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Glucose Intolerance, Sleep Disturbance
- Trial name
- NCT06366399
- Testing
- Resistance Exercise Timing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Obesity
Clinical Efficacy and Safety of a Laparoscopic Sleeve Gastrectomy in Obese Patients
This study aim to evaluate the clinical efficacy and safety after laparoscopic sleeve gastrectomy in patients with obesity. 300 patients with obesity and 49 healthy individuals with normal BMI were enrolled.
- Trial name
- NCT04548232
- Testing
- Laparoscopic sleeve gastrectomy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Type2 Diabetes, NAFLD
Effects of VLCD and Bariatric Surgery in Patients With Type 2 Diabetes
The investigators are therefore interested to explore the effects of VLCD and different bariatric surgery procedures to changes in the physical deposition of fat in organs which regulate glucose metabolism (i.e.
- Conditions
- Type2 Diabetes, NAFLD, Obesity
- Trial name
- BARIATRICMRI (NCT05092399)
- Testing
- Bariatric Surgery
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Nottingham
Obesity, Prediabetic State
Physical Activity and Obesity
The purpose of the study is to see if a twelve-week exercise intervention in overweight or obese subjects with pre-diabetes or early disease course type 2 diabetes can lead to improved skeletal muscle capillary blood flow by…
- Conditions
- Obesity, Prediabetic State, Sedentary Lifestyle
- Trial name
- NCT02060240
- Testing
- High Activity
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Obesity, Insulin Resistance
Microbiome Insulin Sensitivity Study
The Microbiome Insulin Sensitivity Study "MISS" is a pilot study designed to study microbiome composition across puberty and how it relates to insulin sensitivity and secretion in obese girls, who are at increased risk for…
- Conditions
- Obesity, Insulin Resistance, Type2 Diabetes
- Trial name
- MISS (NCT03120871)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Diabete Type 2, Obesity
A Study on the Effect of Bariatric Surgery on Glucose Metabolism in Chinese Obese and Type 2 Diabetes Patients
The study will be conducted in the following population: obese patients with normal glucose tolerance (HbA1c ≤ 5.6%, n=12), pre-sugar patients (5.7% ≤ HbA1c ≤ 6.4%, n=18) and patients with T2DM (HbA1c ≥ 6.4% , n=18).
- Trial name
- NCT05894811
- Testing
- oral glucose tolerance test, MRI
- Volunteers
- 48 people
- Sponsor
- Dongyang Liu
Diabetes Mellitus, Type 2, Obesity
Role of Interleukin-6 in Exercise
The purpose of the study is to understand the role of interleukin-6 during physical activity in patients with type 2 diabetes.
- Trial name
- Exil-6 (NCT01073826)
- Testing
- Sport, Tocilizumab, Sitagliptin
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University of Zurich
Type 2 Diabetes Mellitus, Obesity
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
The main purpose of this study is to assess the effect of RO7204239 on insulin sensitivity versus placebo in participants with T2DM and obesity or overweight.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Overweight
- Trial name
- NCT07137585
- Testing
- RO7204239
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Hoffmann-La Roche
Type 2 Diabetes, Obese
Postprandial Metabolism After Bariatric Surgery in Type 2 Diabetes
Bariatric surgery procedures have now been firmly demonstrated to lead to significant improvement and even, in many cases, complete reversal of abnormal glucose homeostasis in type 2 diabetes (T2D).
- Trial name
- CB4 (NCT02815943)
- Testing
- biliopancreatic diversion with duodenal switch, sleeve gastrectomy, liquid meal
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cardiovascular Disease, Dyslipidemia
An Intervention to Improve Management of Dyslipidemia in Primary Care
To assess the effectiveness of a clinical audit and physician based intervention in improving the management of dyslipidemia at Health centres in the Southeast Health Region of Jamaica
- Conditions
- Cardiovascular Disease, Dyslipidemia, Diabetes Melletus, Obesity
- Trial name
- NCT02438943
- Testing
- Audit, Physician Intervention
- Where
- Jamaica
- Volunteers
- 500 people
- Sponsor
- The University of The West Indies
Obesity, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities
Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)
This Phase 3 study evaluates the efficacy and safety of once-weekly subcutaneous tirzepatide (a dual GIP and GLP-1 receptor agonist) at 5 mg, 10 mg, or 15 mg versus placebo, each used with a reduced-calorie diet and increased…
- Trial name
- SURMOUNT-1 (NCT07481747)
- Testing
- Tirzepatide, Reduced-calorie diet
- Where
- China
- Volunteers
- 2,539 people
- Sponsor
- Hudson Biotech
Bariatric Surgery, Obese
Comparative Evaluation of the Evolution of Arterial and Microcirculatory Endothelial Function in Obese Patients With Type-2 Diabetes Versus Non-diabetic Obese Patients After a First Bariatric Surgery
The weight reduction obtained after a first bariatric surgery would improve the vascular (correction of endothelial dysfunction, improvement of arterial wall compliance and evolution of the atherothrombotic process) and…
- Conditions
- Bariatric Surgery, Obese, Type2 Diabetes
- Trial name
- BariVaDia (NCT03636243)
- Testing
- Vascularly biological assessment, Analysis of vasomotor endothelial function, Analysis of arterial compliance
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
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