Clinical trials: Obesity in Diabetes
Dysglycemia, Obesity
Effects of Cinnamon Supplementation on Glucose Metabolism in Patients With Pre-diabetes
The transition from normal glucose tolerance to overt type 2 diabetes mellitus (T2D) encompasses a variety of glycemic abnormalities that are commonly referred to as 'prediabetes'.
- Trial name
- Cinnamon (NCT03219411)
- Testing
- Cinnamon
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus, Type 2, Hypertension
The Effect of Progressive Resistance Exercise Training (PRET) on CVRF in Adults With ID.
Thanks to improved healthcare, the life expectancy of people with ID is increasing and is approaching that of the general population.
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Hypercholesterolemia, Obesity
- Trial name
- PRET (NCT06579898)
- Testing
- Progressive resistance exercise training
- Where
- 3 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- Erasmus Medical Center
Diabetes Mellitus, Type 2, Obesity
Effectiveness of a Weight Management Programme on Diabetes Remission in Obese Patients With Early Diabetes
The goal of this clinical trial is to determine the effectiveness of a weight management programme in primary care in achieving diabetes remission in obese patients with early diabetes.
- Trial name
- NCT05762120
- Testing
- Weight Management Programme
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- National Healthcare Group Polyclinics
Healthy Participants, Obesity
A Study Investigating the Safety, Absorption, Elimination, and the Effect on the Immune System of ACI-19764 in Healthy Participants and in Participants With Cardiovascular Risk Factors
The main purposes of this study are: to investigate the safety and tolerability of ACI-19764 when it is administered to healthy participants and participants with cardiovascular risk factors to determine how quickly and to what…
- Conditions
- Healthy Participants, Obesity, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- NCT07463196
- Testing
- ACI-19764 at dose A1, ACI-19764 at dose A2, ACI-19764 at dose A3
- Where
- Netherlands
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- AC Immune SA
Obesity, Sarcopenia
Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals
This randomized controlled trial aims to investigate the effects of a 24-week home-based progressive resistance exercise program combined with tirzepatide treatment on skeletal muscle mass, muscle quality, and functional capacity…
- Conditions
- Obesity, Sarcopenia, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities
- Trial name
- NCT07609160
- Testing
- Resistance exercise, Lifestyle recommendations
- Volunteers
- 108 people
- Sponsor
- Acibadem University
Type2 Diabetes, Type 2 Diabetes Mellitus
Randomised Placebo-controlled Study of FMT to Impact Body Weight and Glycemic Control in Obese Subjects With T2DM
Faecal microbiota transplantation (FMT) represents a clinically feasible way to restore the gut microbial ecology, and has proven to be a breakthrough for the treatment of recurrent Clostridium difficile infection.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus, Obese
- Trial name
- NCT03127696
- Testing
- Fecal Microbiota Transplantation, Lifestyle Modification Program
- Where
- Hong Kong
- Volunteers
- 61 people
- Sponsor
- Chinese University of Hong Kong
Diabetes, Hypertension
Mobile Phone-based Intervention for Promoting Healthy Habits and Weight Loss
A self administered 16 weeks plus follow up study to explore the efficacy of mobile phone driven apps for stress reduction coupled with guidance for healthy living among obese and overweight populations.
- Conditions
- Diabetes, Hypertension, Pre-diabetes, Overweight
- Trial name
- NCT02621008
- Testing
- Stress Reduction& Healthy living
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Eco Fusion
Diabetes Mellitus
Influence of Different Approaches to Dietary Advising on the Effects of Acarbose Treatment in Obese Diabetic Patients Under Real-life Setting
It has been recently suggested, that not the diet by itself, but also patient's adherence to dietary recommendations and all actions performed to improve dietary compliance, may be a significant factor influencing blood glucose…
- Trial name
- CATERING (NCT01333774)
- Testing
- Glucobay (Acarbose, BAYG5421)
- Where
- Poland
- Volunteers
- 423 people
- Sponsor
- Bayer
Type 2 Diabetes, Overweight and Obesity
A Phase I Study of GZR18 Injection in Healthy Subjects
This trial is conducted in China. The aim of the trial is to evaluate the safety and tolerability of GZR18 injection in healthy subjects following single dose and once-weekly dose for 2 consecutive weeks until reaching the target…
- Trial name
- NCT06548997
- Testing
- GZR18
- Where
- China
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Type 2 Diabetes, Obesity
Examination of the Anti-inflammatory and Insulin Sensitizing Properties of Doxycycline in Humans
Obesity is a heightened state of inflammation in which production of cytokines and matrix metalloproteinases (MMPs) result in loss of function of insulin receptors and insulin resistance.
- Trial name
- DOXY (NCT01375491)
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Healthy, Obesity & Overweight
Growth Hormone Resistance of Beta-cells
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with impaired fasting glucose or impaired…
- Conditions
- Healthy, Obesity & Overweight, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (Prediabetes)
- Trial name
- GHRB-C (NCT07581860)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Diabetes Mellitus, Obesity-Related Malignant Neoplasm
Eat, Move, Live Program for the Reduction of Cancer and Chronic Disease Risk in Underserved Communities
This clinical trial tests the Eat, Move, Live (EML) Program in reducing the risk of chronic diseases among underserved communities by improving healthy lifestyle practices, increasing physical activity and encouraging healthy…
- Trial name
- NCT05414396
- Testing
- Behavioral Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Obesity, Abdominal, Diabetes
Exploratory Evaluation of the Effect of Cholestyramine on Serum Levels of POPs in Obese Female Patients
Environmental endocrine disruptors (EDCs) represent a major problem for human health.Some PEEs can accumulate in the fatty tissue of the human body thanks to their lipophilic nature, and are known as persistent organic pollutants…
- Conditions
- Obesity, Abdominal, Diabetes, Bariatric Surgery Candidate
- Trial name
- OBESE (NCT05966727)
- Testing
- Cholestyramine Powder
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Type 2 Diabetes
Anti-inflammatory Effects of the Fiber
This study will help elucidate the mechanism underlying the cardioprotective and anti-diabetes effect of dietary fiber by exploring a comprehensive set of inflammatory and oxidative stress markers, based on a contemporary…
- Trial name
- NCT02868788
- Testing
- dietary fiber, HFHC meal
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University at Buffalo
Obese, Overweight
Effect of Akkermansia Muciniphila WST01 Strain in Overweight or Obese Patients With Type 2 Diabetes
The purpose of this study is to conduct a randomized, double-blinded, placebo-controlled, multicenter clinical trial, evaluating the glucose-lowering and weight-loss effects of Akkermansia muciniphila WST01 strain in overweight…
- Conditions
- Obese, Overweight, Type 2 Diabetes
- Trial name
- NCT04797442
- Testing
- WST01 strain product
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetes Mellitus, Type 2, Overweight
Getting in Balance: A Workplace Diabetes Prevention Intervention Trial
This study evaluates two group-based Diabetes Prevention Program (DPP) lifestyle interventions delivered in the workplace to individuals at risk for pre-diabetes: 1) an in-person group-based lifestyle intervention; and 2) an…
- Conditions
- Diabetes Mellitus, Type 2, Overweight, Obesity
- Trial name
- GIBW (NCT02589873)
- Testing
- In-Person Diabetes Prevention Program, Online Diabetes Prevention Program
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obesity, Diabetes Mellitus, Type 2
Bariatric and Metabolic Surgery in Patients Over 65 Years of Age
A retrospective multicenter study that will analyze the results of surgical treatment of obesity in patients over 65 years of age.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- 65plus (NCT06081413)
- Testing
- bariatric surgery
- Where
- Poland
- Volunteers
- 284 people
- Sponsor
- University of Warmia and Mazury in Olsztyn
Obesity
Reward Mechanisms in Obesity
The study aims to investigate the effects of 3.0 mg of liraglutide on reward brain circuits in human obesity and to better understand its effects on weight loss (in patients without diabetes).
- Trial name
- LIRAOB (NCT03347890)
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zoltan Pataky
Obesity, Type 2 Diabetes
Effects of Glucagon Like Peptide-1(GLP-1) and Liraglutide on Brain Satiety and Reward Circuits and Feeding Behavior in Diabetes
The aim of this study is to investigate if endogenous Glucagon Like Peptide -1 (GLP-1) has an effect on brain satiety and reward systems and if there are alterations in obese patients with type 2 diabetes (T2DM).
- Trial name
- LIBRA (NCT01363609)
- Testing
- Liraglutide treatment 12 weeks, insulin glargine treatment, GLP-1 receptor antagonist
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Obesity, Liver Diseases
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting…
- Conditions
- Obesity, Liver Diseases, Liver Fibrosis, Liver Fat
- Trial name
- NCT06138821
- Testing
- ESG + lifestyle modification, Lifestyle modification
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
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