Clinical trials: Obesity in Diabetes
Diabetes Mellitus, Hyperglycemia
Intervening in Diabetes With Healthy Eating, Activity, and Linkages To Healthcare - The I-D-HEALTH Study
The purpose of this study is to compare ways of giving advice and providing support to improve diet and physical activity in adult primary care patients with elevated body mass index and dysglycemia.
- Conditions
- Diabetes Mellitus, Hyperglycemia, Obesity, Glucose Metabolism Disorders
- Trial name
- I-D-HEALTH (NCT01435603)
- Testing
- Standard Lifestyle Advice, Advice Plus Lifestyle Intervention
- Where
- 2 sites in United States
- Volunteers
- 331 people
- Sponsor
- Northwestern University
Morbid Obesity, Type 2 Diabetes Mellitus
Caloric Restriction and Insulin Secretion
Caloric restriction in obese diabetic patients quickly improves glucose control, independently from weight loss. However, the early effects of a very-low calorie diet (VLCD) on insulin sensitivity and insulin secretion in…
- Trial name
- NCT01447524
- Testing
- Very Low Calorie Diet
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Rome Tor Vergata
Diabetes Mellitus, Type 1, Obesity, Childhood
Family-Based Treatment for Type 1 Diabetes
Type 1 Diabetes carries high burden for affected youth and their families. Advances in insulin therapy and technology have been associated with increased obesity with 1/3 adolescents being overweight/obese.
- Conditions
- Diabetes Mellitus, Type 1, Obesity, Childhood, Overweight, Comorbidities and Coexisting Conditions
- Trial name
- FBTT1D (NCT05756361)
- Testing
- Family-Based Treatment for T1D
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- State University of New York at Buffalo
Pre Diabetes, Overweight and Obesity
A Digital Therapy for Diabetes Prevention Among Overweight Adults in Terengganu, Malaysia
The modern world revolves around technology; unsurprisingly companies are leveraging the expertise of the digital tech industry to aid in the prevention of chronic diseases.
- Trial name
- NCT03997656
- Testing
- MyDiPP (Malaysia Diabetes Prevention Program), usual care
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Sultan Zainal Abidin
Diabetes, Heart Diseases
Personalised Responses to Dietary Composition Trial
The foods we eat - our diet - can affect whether we develop diseases during our lives, such as diabetes or heart disease. This is because the amount and types of foods we eat can affect our weight, and because different foods are…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- PREDICT (NCT03479866)
- Testing
- Dietary intervention
- Where
- United Kingdom
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Polycystic Ovarian Syndrome, Pelvic Endometriosis
Prevalence of HbA1C in Women With PCOS
Women with PCOS have been observed to be potential diabetics.Recently,American Diabetes Association has suggested screening of women with PCOS for HbA1C.
- Conditions
- Polycystic Ovarian Syndrome, Pelvic Endometriosis, Insulin Resistance, Non-insulin Dependent Diabetes Mellitus
- Trial name
- WHI (NCT01838122)
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Southern Cross Fertility Centre
Obesity and Type 2 Diabetes
Effects of Enavogliflozin on Coronary Microvascular and Cardiac Function in Obesity
The goal of this study is to analyze the effects of enavogliflozin on heart function and coronary microvascular function in obese patients compared to a placebo, and to evaluate the improvement in cardiopulmonary exercise…
- Trial name
- ENVY (NCT06782139)
- Testing
- Enavogliflozin
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Korea University Anam Hospital
Obesity, Overweight
Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes Mellitus
This study will determine whether resting beta cells (cells in the pancreas that produce insulin) for 2 weeks will improve the ability of patients with Type 2 diabetes mellitus (T2DM) to make insulin.
- Conditions
- Obesity, Overweight, Diabetes Mellitus, Type 2
- Trial name
- NCT00445627
- Testing
- Metformin, Insulin, Nutrition counseling
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiac Surgery, Sternal Wound Infection
Safety and Efficacy of an Antibiotic Implant in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Infection
The purpose of this study is to determine whether the gentamicin-collagen sponge is safe and effective in preventing sternal wound infections in patients undergoing cardiac surgery who are at a greater risk of developing sternal…
- Trial name
- NCT00600483
- Testing
- gentamicin-collagen sponge dipped in saline
- Where
- 43 sites in United States
- Volunteers
- 1,502 people
- Sponsor
- Innocoll
Overweight/Obesity, Glucose Intolerance
Effects of 3 Months of Supervised Exercise Training
The incidence of type 2 diabetes is increasing worldwide. Because of cardiovascular morbidity and mortality associated with type 2 diabetes, it is imperative to propose methods of prevention and this in early stage of abnormal…
- Conditions
- Overweight/Obesity, Glucose Intolerance, Type 2 Diabetes, Sedentarity
- Trial name
- NCT01349166
- Testing
- Behavior: Supervised physical training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiovascular Diseases, Prevention
Cardiovascular Health Promotion Among African-Americans by FAITH!
Given the importance of healthy lifestyle practices to cardiovascular disease (CVD) prevention and the utility of church-based interventions in African-American adults, the investigators developed a theory-informed…
- Conditions
- Cardiovascular Diseases, Prevention, Physical Activity, Diet Modification
- Trial name
- FAITH! (NCT03084822)
- Testing
- FAITH! App digital intervention
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertension, Cardiovascular Diseases
Cardiovascular Disease Risk Factors in Chinese American Immigrants
The Chinese population is currently the fastest growing ethnic group in New York City (NYC). Research has shown that Chinese immigrants living in NYC have higher rates of cardiovascular disease (CVD) than individuals in China.
- Conditions
- Hypertension, Cardiovascular Diseases, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- CHA-CHA (NCT00362128)
- Where
- United States
- Volunteers
- 2,072 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Obesity, Overweight
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA)…
- Conditions
- Obesity, Overweight, Osteoarthritis, Knee, Obstructive Sleep Apnea
- Trial name
- TRIUMPH-1 (NCT05929066)
- Testing
- Retatrutide
- Where
- 134 sites in United States, Australia and 10 more
- Volunteers
- 2,335 people
- Sponsor
- Eli Lilly and Company
Obesity, Uric Acid Stones
Phentermine/Topiramate for Uric Acid Stones
The investigator proposes an 18 month, feasibility pilot study, randomizing obese and diabetic individuals with pure uric acid nephrolithiasis (UAN) or mixed calcium oxalate (CO) UAN to either phentermine/topiramate or a…
- Conditions
- Obesity, Uric Acid Stones, Type 2 Diabetes Mellitus in Obese, Pre-Diabetes
- Trial name
- NCT04621929
- Testing
- Phentermine / Topiramate Oral Product, Citrate Salts, Allopurinol, Diet
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Obesity, Diabetes Mellitus, Type 2
A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight
This study will look at how much weight participants will lose and how much blood sugar control they achieve from the start to the end of the study.
- Trial name
- NCT05649137
- Testing
- Semaglutide
- Where
- 76 sites in United States, Bulgaria and 6 more
- Volunteers
- 512 people
- Sponsor
- Novo Nordisk A/S
Obesity, Diabetes
Evaluation of the Clinical Spectrum of Diabetes and Obesity in Youth and Adults
Background: Diabetes and obesity are chronic diseases. They can affect blood flow and how the body processes nutrients, and complications over time can lead to early death.
- Conditions
- Obesity, Diabetes, Metabolic Disorders
- Trial name
- NCT07388537
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Prediabetes, Gestational Diabetes
Treating Prediabetes in the First Trimester
The investigators plan to study a sample of women with prediabetes (diagnosed by Hemoglobin A1c (HbA1c) 5.7-6.4% or fasting plasma glucose (FPG) 92-125 mg/dL) in the first trimester of pregnancy, and patients will be randomized…
- Trial name
- NCT01926457
- Testing
- Treatment of Prediabetes
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Diabetes, Obesity
A Study of the Function of Hormones Present In Taste Buds
The purpose of this study is to find out whether the hormones in the taste buds are affected by tasting and eating food, and also whether these hormone levels are affected by an increase in body weight or type 2 diabetes.
- Conditions
- Diabetes, Obesity, Pre-Diabetes, Metabolic Syndrome
- Trial name
- NCT00233298
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Menopause, Type 2 Diabetes
Menopausal Hormone Therapy, GLP-1 Agonists, and Glucose and Energy Homeostasis in Postmenopausal Women With Overweight/Obesity and Impaired Glucose Homeostasis
The overall aim is to investigate the hypothesis that restoring E2 levels through MHT improves glucose and energy homeostasis and potentiates the beneficial effects of GLP-1RA in early postmenopausal women with pre- or existing…
- Trial name
- DECLARED-CT (NCT06715514)
- Testing
- GLP-1 Receptor Agonist, Menopausal Hormone Therapy
- Where
- Switzerland
- Volunteers
- 96 people
- Sponsor
- Lia Bally
Obese Patients, Type 2 Diabetes Mellitus
Impact of Gastric Bypass Surgery on Risk of CVD in Type 2 Diabetes Mellitus
Central hypothesis is: Gastric bypass surgery reduces the risk of CVD in morbidly obese subjects (defined as BMI ≥35 kg/m2) with T2DM.
- Trial name
- NCT00444392
- Testing
- Calorie controlled diabetic diet for the control patients
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vanderbilt University
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