Clinical trials: Obesity in Diabetes
Obesity, Overweight
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA)…
- Conditions
- Obesity, Overweight, Osteoarthritis, Knee, Obstructive Sleep Apnea
- Trial name
- TRIUMPH-1 (NCT05929066)
- Testing
- Retatrutide
- Where
- 134 sites in United States, Australia and 10 more
- Volunteers
- 2,335 people
- Sponsor
- Eli Lilly and Company
Obesity, Prediabetic State
Lifestyle-Related Health Outcomes in Prediabetes and Diabetes
This study looks as how a health education intervention strategy effects health outcomes in overweight and obese adolescents.
- Conditions
- Obesity, Prediabetic State, Type 2 Diabetes
- Trial name
- NCT02535169
- Testing
- Health Education and Coaching Strategy, Dietary consult
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Indiana University
Severe to Morbid Obesity and Type 2 Diabetes
Study of Weight Loss Using Gastric Stimulation in Obese Patients With Type 2 Diabetes
The purpose of this study is to test the effect of an implanted device that stimulates the stomach on weight loss in patients suffering from obesity and type 2 diabetes.
- Trial name
- ASSIST (NCT00200018)
- Testing
- Enterra Therapy System (H9900014)
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- MedtronicNeuro
Cardiovascular Diseases, Obesity Prevention
Mediterranean Diet Education in Shift Nurses: Effects on Sleep, Activity, and Health Parameters
This study aimed to evaluate the effects of Mediterranean diet education on sleep quality, physical activity levels, blood parameters, and anthropometric measurements among shift-working nurses.
- Conditions
- Cardiovascular Diseases, Obesity Prevention, Atheroscleroses, Hypertension
- Trial name
- NCT07123610
- Testing
- Mediterranean Diet Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Obesity, Type 2 Diabetes Mellitus (T2DM)
Magnetic Duodeno-Ileal Chile Study
The objective of the MagDI Chile Study is to evaluate the feasibility / performance, safety, and initial efficacy of the MagDI System in eligible participants who are indicated for a duodeno-ileal (small bowel) side-to-side…
- Trial name
- NCT06613724
- Testing
- Magnet System, DI Biofragmentable
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- GT Metabolic Solutions, Inc.
Obesity, Type 2 Diabetes
Strength Training and Nutrition Development for African American Youth
The investigators are conducting an intervention study to examine the effects of a 16-week exercise and diet interventions on prevention of disease, specifically type 2 diabetes and heart disease, in African American youth.
- Conditions
- Obesity, Type 2 Diabetes, Cardiovascular Risk, Cancer
- Trial name
- STAND (NCT01441323)
- Testing
- Nutrition, Strength Training & Nutrition
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Continuous Glucose Monitoring, Prediabetic State
Effect of Real-time Continuous Glucose Monitoring System in Overweight or Obese Adults With Prediabetes
In Korea, 5 million adults aged 30 years or older have diabetes. The development and expansion of Korea's economy and society, has led to dramatic chances in people's lifestyle and diet habits, and an increase in life expectancy.
- Conditions
- Continuous Glucose Monitoring, Prediabetic State, Obesity
- Trial name
- NCT04099550
- Testing
- RT-CGM, SMBG
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
CKD, Diabetic Kidney Disease
Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy
This randomized study evaluates the effect of subcutaneous semaglutide /in combination with lifestyle counseling in patients with type 2 diabetes mellitus (T2DM), overweight/obesity, and stage 4-5 chronic kidney disease (CKD) or…
- Conditions
- CKD, Diabetic Kidney Disease, Type 2 Diabetes Mellitus in Obese, Obesity
- Trial name
- RAISE-KT (NCT04741074)
- Testing
- Semaglutide 2 mg/1.5 ml (1.34 mg/ml), prefilled pen-injector for subcutaneous injection solution
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Geisinger Clinic
Prediabetes, Obesity
Diabetes Prevention Program in Adults of the Yaqui Tribe of Hermosillo, Sonora at Risk of Diabetes
Diabetes is a major non communicable chronic diseases in the world. It occupies the fourth or fifth leading cause of death in most high-income countries and there is strong evidence that has epidemic proportions in many…
- Conditions
- Prediabetes, Obesity, Overweight
- Trial name
- NCT02899390
- Testing
- Lifestyle Intervention
- Where
- 3 sites in Mexico
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Obesity, Diabetes Mellitus Type 2
Effect of the Omentectomy on the Hyperglycemia and the Resistance to the Insulin in Patients With Morbid Obesity
To determine if the omentectomy diminishes hyperglycemia and improves the resistance to the insulin in patients with morbid obesity and propensity to develop to Diabetes Mellitus type 2.
- Trial name
- omentectomy (NCT00454597)
- Testing
- omentectomy
- Where
- Mexico
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidad de Guanajuato
Type 2 Diabetes Mellitus (T2DM), Overweight , Obesity
A Study to Evaluate Different Administration Conditions and the Food Effect of MWN109 Tablets in Chinese Participants
This is a randomized, open-label, multiple-dose study to evaluate the effects of different volumes of administration water, post-dose fasting duration, and high-fat diet on the pharmacokinetics of the 15 mg dose of MWN109 tablets…
- Trial name
- NCT07801326
- Testing
- MWN109 Tablets
- Where
- China
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Severe Obesity, Type 2 Diabetes Mellitus in Obese
L-Cell Activity in Small Intestine as Biliopancreatic Loop in Obese Patients With DM2 Submitted to RYGBP
Prevalence of Obesity and its association with Diabetes Mellitus 2 (DM2) affect a significant percentage of the world's population with great socioeconomic impact, especially for developing countries.
- Trial name
- NCT05446415
- Testing
- Analyze basal expression incretin for immunolabeling and mRNA expression glucagon-like secretion peptide-1 (GLP-1) and peptide YY (PYY 3-36) incretins by L cells.
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Obese, Normal Body Weight
Cold Induced Changes in White Adipose
An adaptation to a cold environment is a tendency to generate heat within our body. Some of this heat comes from our fat tissue.
- Conditions
- Obese, Normal Body Weight, Prediabetes, Metabolic Syndrome
- Trial name
- NCT02596776
- Testing
- Fat biopsy, Propranolol and fat biopsy, heavy water and fat biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Ferritin, Insulin Sensitivity
Blood Donation Could Improve Insulin Sensitivity
Studies in the literature suggest that people with obesity have an excess of stored iron. There is possibly an inverse relationship between ferritin levels and the actions of insulin on glycemic control.
- Conditions
- Ferritin, Insulin Sensitivity, Blood Donation
- Trial name
- GLUCFER (NCT05791968)
- Testing
- Whole blood standard donation
- Where
- Spain
- Volunteers
- 89 people
- Sponsor
- University of Castilla-La Mancha
Obesity, Diabetes
"ISIS" Study of Sex Differences in Characteristics of Adiposity and Metabolism
The purpose of this study is to characterize differences in the structure and function of the body fat from two different parts of the body in young, healthy men and women.
- Trial name
- ISIS (NCT00704197)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Type 2 Diabetes
Feel4Diabetes-study
The aim of the Feel4Diabetes-study is to develop, implement and evaluate a community-based intervention aiming to create a more supportive social and physical environment to promote lifestyle and behaviour change to prevent type…
- Trial name
- Feel4Diabetes (NCT02393872)
- Testing
- Feel4Diabetes-intervention
- Where
- Greece
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Type 2 Diabetes, Control Condition
Exercise and Protein Efficiency in T2D
In this randomized controlled trial, 30 older adults (aged> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program.
- Trial name
- ADA (NCT07477067)
- Testing
- 12 week progressive exercise training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Obesity
SYNCHRONIZE®-START- A Study to Test Whether Survodutide Helps People Living With Overweight or Obesity Who do Not Have Diabetes to Lose Weight
This study is open to adults with overweight or obesity. People can join the study if they have a body mass index (BMI) of 30 kg/m² or more, or a BMI of 27 kg/m² or more with at least one weight- related health problem.
- Trial name
- NCT07855900
- Testing
- Survodutide
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- Boehringer Ingelheim
Overweight, Diabetes Type 2
The Efficacy of Bariatric Surgery Compared to Medical Therapy in Controlling Type2 Diabetes Mellitus in Patients With Non Morbid Obesity.
The growing incidence of obesity and type2 DM globally is widely recognized as one of the most challenging contemporary threats to public health.
- Trial name
- NCT02036138
- Testing
- Laparoscopic Sleeve Gastrectomy, Laparoscopic Roux-en-Y Gastric Bypass, Advanced Medical Therapy
- Where
- Israel
- Volunteers
- 76 people
- Sponsor
- Hadassah Medical Organization
Osteoporosis
The Oswestry Metabolic BONE Cohort
Osteoporosis is a chronic condition characterised by reduced bone mass and microarchitectural deterioration of bone tissue leading to fracture.
- Trial name
- OsBONE (NCT07014306)
- Testing
- MRI, Computed tomography
- Where
- United Kingdom
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
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