Clinical trials: Obesity in Diabetes
Type 2 Diabetes
Impact of Body Composition and Exercise on Clinical, Metabolic and Molecular Parameters in Type 2 Diabetics in Qatar
The prevalence of type 2 diabetes (T2DM) is increasing sharply around the world and obesity and sedentary lifestyles are driving the epidemic. Obesity is often, but not always present in patients with T2DM.
- Trial name
- NCT04081064
- Testing
- 10-week exercise programme based on aerobic interval and resistance training
- Where
- Qatar
- Volunteers
- 60 people
- Sponsor
- Hamad Medical Corporation
Obesity, Diabetes
Gelesis Glycemic Index Study
A study to determine glucose and insulin responses to 50g and 100 g of carbohydrate with and without Gelesis200.
- Conditions
- Obesity, Diabetes, PreDiabetes
- Trial name
- GLIDE (NCT03124134)
- Testing
- Gelesis200
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gelesis, Inc.
Diabetes Mellitus Type 2 in Obese, Anxiety
Influence of Probiotics in Diabetic Cardiopathies With Excessive Weight
Today in Brazil, 6.9% of the population has Diabetes Mellitus 2 (DM2). In the world, there are about 422 million people with DM2.
- Conditions
- Diabetes Mellitus Type 2 in Obese, Anxiety, Cardiopathy
- Trial name
- NCT03904901
- Testing
- Probiotics
- Where
- Brazil
- Volunteers
- 4 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Weight Loss, Obesity
Weight Loss Using a Feedback Device in Obese People With the Metabolic Syndrome
The purpose of this study is to determine if a weight loss app (VA MOVE!® Coach App) along with regularly scheduled telephone counseling, will motivate obese people with metabolic syndrome to lose weight and improve the symptoms…
- Conditions
- Weight Loss, Obesity, Pre-Diabetes, Metabolic Syndrome
- Trial name
- NCT03491930
- Testing
- VA MOVE! Coach app, Telephone Coaching, Standard of Care for weight loss.
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rockefeller University
Diabetes Mellitus Type 2 in Obese
Cochlear-Vestibular Ganglion (CVG) in Newly Diagnosed Type 2 Diabetes Patients
The proposed study is an integrative scientific undertaking, reflecting the input of experts in the behavioral sciences, mHealth technology, computational biology, endocrinology, biochemistry, and nutrition.
- Trial name
- NCT02668328
- Testing
- Social Cognitive Theory Tailored Behavioral Intervention
- Sponsor
- NYU Langone Health
Obesity
A Study on Efficacy and Safety of Topiramate in the Treatment of Patients With Obesity
The purpose of this study is to compare the efficacy and safety of topiramate (96, 192, and 256mg daily) with placebo in long-term treatment of obesity.
- Trial name
- NCT00236639
- Testing
- topiramate
- Volunteers
- 1,293 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Diabetes, Pre-diabetes
Metformin at the Cellular Level and Dosing for Diabetes Mellitus (DM)
The investigators know that metformin works at the level of the cells in the body by acting on a protein called Cyclic amine monophosphate- Response Binding Elements (CREB) binding protein or Constitutive Reverter of eIF2α…
- Conditions
- Diabetes, Pre-diabetes, Obesity
- Trial name
- NCT01876992
- Testing
- Metformin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 2 Diabetes, Obesity
Resveratrol in Type2 Diabetes and Obesity
The main objective of this study is to investigate the effect of resveratrol (plant derived food supplement) on inflammatory mediators and insulin resistance at the cellular and molecular level in obese non diabetic and type 2…
- Conditions
- Type 2 Diabetes, Obesity, Insulin Resistance
- Trial name
- NCT01158417
- Testing
- Resveratrol 40 mg oral three times a day, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Obesity, Non-Alcoholic Fatty Liver Disease
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity.
- Conditions
- Obesity, Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2, Healthy
- Trial name
- ATM (NCT06571474)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Prediabetes, Hyperglycemia
β-alanine Supplementation in Adults With Overweight/Obesity
The study will investigate the safety, feasibility, and efficacy of beta-alanine supplementation in adults with overweight or obesity.
- Conditions
- Prediabetes, Hyperglycemia, Overweight or Obesity
- Trial name
- BASA-O (NCT05329610)
- Testing
- Beta-alanine
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Nottingham Trent University
Type 2 Diabetes, Obesity
The Medically Reproducing Bariatric Surgery (MRB) II Study
Roux-en-Y (RYGB) gastric bypass reduces the size and capacity of the stomach and bypasses a portion of the small intestine which leads to decreased food intake and higher levels of a gut hormone called GLP-1…
- Trial name
- NCT06363747
- Testing
- Very Low Calorie Diet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Durham VA Medical Center
GDM
Healthy Habits During and After Gestational Diabetes
Gestational diabetes mellitus (GDM) is associated with an increased risk of childhood obesity and other adverse health outcomes.
- Trial name
- VALID III (NCT07717515)
- Testing
- Hybrid intervention, Standard Care with Passive Web Access
- Where
- Vietnam
- Volunteers
- 2,546 people
- Sponsor
- Thai Binh University of Medicine and Pharmacy
Heart Diseases
Identifying Genes That May Increase the Risk for Heart Disease in African Americans
Heart disease and stroke disproportionately affect African Americans in the United States. These conditions are likely caused by both environmental and genetic factors.
- Trial name
- NCT00344136
- Where
- United States
- Volunteers
- 5,302 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Insulin Resistance
Microbiome Insulin Sensitivity Study
The Microbiome Insulin Sensitivity Study "MISS" is a pilot study designed to study microbiome composition across puberty and how it relates to insulin sensitivity and secretion in obese girls, who are at increased risk for…
- Conditions
- Obesity, Insulin Resistance, Type2 Diabetes
- Trial name
- MISS (NCT03120871)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes Mellitus
A Study To Investigate The Safety And Metabolism Of GSK376501 In Overweight Subjects
This study represents the first administration of GSK376501 in humans and the goal is to evaluate its initial safety and tolerability. The way the human body processes GSK376501 will also be determined.
- Trial name
- NCT00404963
- Testing
- GSK376501
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
High-Risk Pregnancy
Longitudinal Measures of Leptin in Pregnant Women Who Developed Preeclampsia
Background: Obesity in pregnancy is increasing and is a risk factor for metabolic pathology such as preeclampsia. Leptin is an adipokine which has a direct relationship to obesity.
- Trial name
- NCT01649167
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Materno-Perinatal Hospital of the State of Mexico
Obesity, Nonalcoholic Fatty Liver
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity.
- Conditions
- Obesity, Nonalcoholic Fatty Liver, Diabetes Type 2, Healthy
- Trial name
- ATM (NCT06335771)
- Testing
- Dietary consultation weight loss intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Type 2 Diabetes Mellitus
Pharmacodynamic and Pharmacokinetic Effects of Insulin Glulisine in Obese Subjects With Type 2 Diabetes After a Standard Meal in Comparison to Insulin Aspart
Primary Objective: To assess the effect of insulin glulisine on the post-prandial plasma glucose excursion during the first hour after a standard meal in comparison to insulin aspart in obese subjects with type 2 diabetes.
- Trial name
- NCT01159353
- Testing
- Insulin glulisine, Insulin aspart
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Sanofi
Vitamin D Deficiency, Type2 Diabetes
Effect of Vitamin D Supplementation on Inflammatory Markers
Previous studies have shown that improving vitamin D status among the elderly may lead to an improvement in some inflammatory markers, especially with patients with type 2 diabetes.
- Trial name
- NCT03782805
- Testing
- cholecalciferol (Euro-Pharm International, Canada)
- Where
- Lebanon
- Volunteers
- 88 people
- Sponsor
- Université d'Auvergne
Insulin Resistance, Prediabetic State
Dexamethasone/Pancreatic Clamp P&F
This is a single-center, prospective, randomized, controlled (crossover) clinical study designed to investigate the specific dose-response impact of insulin infusion rate (IIR) on blood glucose levels during a pancreatic clamp…
- Conditions
- Insulin Resistance, Prediabetic State, Non-Alcoholic Fatty Liver Disease, Overweight and Obesity
- Trial name
- NCT06126354
- Testing
- Insulin human, Octreotide Acetate, Glucagon
- Where
- United States
- Sponsor
- Columbia University
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