Clinical trials: Obesity in Diabetes
Obesity
A First-In-Human Study of ARO-INHBE in Adults With Obesity With and Without Type 2 Diabetes Mellitus
This is a Phase 1/2a double-blind dose-escalating study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple doses of ARO-INHBE in adult participants with obesity (in Part…
- Trial name
- NCT06700538
- Testing
- ARO-INHBE, Tirzepatide
- Where
- 15 sites in Australia, Canada and 2 more
- Volunteers
- 190 people
- Sponsor
- Arrowhead Pharmaceuticals
Overweight Children With Type 2 Diabetes Risk
Prevention of Diabetes in Overweight/Obese Preadolescent Children
Background: The global pandemic obesity has led to increased risk for prediabetes and type 2 diabetes (T2D). Objectives: (i) To evaluate the effect of a 22 weeks multidisciplinary intervention program including exercise on T2D…
- Trial name
- PREDIKID (NCT03027726)
- Testing
- lifestyle and psycho-educational program, Exercise plus lifestyle and psycho-educational program
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- University of the Basque Country (UPV/EHU)
Metabolism and Nutrition Disorder, Obesity
The Effect of Liraglutide on Body Weight in Obese Subjects Without Diabetes
This trial is conducted in Europe. The purpose of the 20-week trial is to investigate the efficacy of liraglutide to induce body weight loss and the purpose of the extension is to evaluate the long term safety and tolerability of…
- Trial name
- NCT00422058
- Testing
- liraglutide, orlistat
- Where
- 19 sites in Belgium, Czechia and 6 more
- Volunteers
- 564 people
- Sponsor
- Novo Nordisk A/S
Pre-diabetes, Overweight and Obesity
A Personalized Diet Study to Reduce Glycemic Exposure
The aim of this 2-phase, randomized clinical trial will be to examine the effects of two behavioral weight loss interventions on weight loss.
- Trial name
- NCT03336411
- Testing
- mHealth, Personalized mHealth
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Type 2 Diabetes, Obesity
The Effect of 3 Different Models of MNT on DM Control in Overweight Patients With T2DM
The American Diabetes Association (ADA), among other medical societies, is strongly recommending medical nutrition therapy (MNT) for prevention and management of type 2 diabetes.
- Trial name
- NCT02520050
- Testing
- Traditional MNT, Structured MNT, Structured MNT plus Weekly Support
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Joslin Diabetes Center
Healthy Volunteers (Diabetes Mellitus, Type 2)
A Research Study of a New Medicine NNC0519-0130 in Healthy People, People With High Body Weight and People With Type 2 Diabetes.
NNC0519-0130 is a new medicine which may possibly help participants with type 2 diabetes, as it is expected to lower elevated sugar levels in the blood. The medicine may also lower the appetite.
- Trial name
- NCT05363774
- Testing
- NNC0519-0130
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus
Study of VI-0521 Compared to Placebo in the Glycemic Management of Obese Diabetics
The purpose of this study is to evaluate the efficacy and safety of VI-0521 compared to placebo in the glycemic management of obese diabetic adults.
- Trial name
- NCT00486291
- Testing
- VI-0521
- Where
- 9 sites in United States
- Volunteers
- 210 people
- Sponsor
- VIVUS LLC
Obesity, Diabetes
Effects of Faba Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control
The investigators hypothesized that consuming crackers or pasta enriched with faba bean fractions (faba bean protein concentrate, faba bean protein isolate, faba bean flour and faba bean starch), would reduce the blood glucose…
- Trial name
- NCT02658591
- Testing
- Crackers/pasta with added faba bean protein concentrate, Crackers/pasta with added faba bean protein isolate, Crackers/pasta with added faba bean starch
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity, Type II Diabetes Mellitus
Yellow Pea Fractions and Short-term Food Intake, Subjective Appetite and Glycemic Response
It is hypothesized that yellow pea protein and fiber will reduce short-term food intake, subjective appetite and glycemic response.
- Conditions
- Obesity, Type II Diabetes Mellitus, Metabolic Syndrome
- Trial name
- NCT01242059
- Testing
- yellow pea protein, yellow pea fiber, Control
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Chronic Disease, Cardiovascular Diseases
Total Health Improvement Program Research Project
The purpose of this study is to assess the effectiveness a 13-week community based nutrition education program to assist participants program in improving in physical and emotional well being and to assess if there are…
- Conditions
- Chronic Disease, Cardiovascular Diseases, Hypertension, Diabetes
- Trial name
- NCT04082585
- Testing
- Total Health Improvement Program
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Pacific Northwest University of Health Sciences
Obesity, Overweight
A Study of CT-868 in Overweight and Obese Participants With Type 2 Diabetes Mellitus
A study to assess the effect of CT-868 in lowering glycated hemoglobin A1c (HbA1c) in overweight and obese participants with inadequately controlled Type 2 diabetes mellitus (T2DM).
- Conditions
- Obesity, Overweight, Type 2 Diabetes Mellitus
- Trial name
- NCT05110846
- Testing
- CT-868
- Where
- 5 sites in Mexico
- Volunteers
- 103 people
- Sponsor
- Carmot Therapeutics, Inc.
Obesity, Obesity, Abdominal
Probiotic Lysate (Postbiotic and Metabiotic) Supplementation for Type 2 Diabetes Patients (DELI_Diab Study)
The current study aim was to conduct placebo-controlled randomize clinical trial to assess the short-term efficacy and safety of postbiotics as an adjunction to the standard anti-diabetic therapy on insulin resistance, glycemic…
- Conditions
- Obesity, Obesity, Abdominal, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05770076
- Testing
- Probiotic lysate (postbiotic and metabiotic)
- Where
- 4 sites in Ukraine
- Volunteers
- 55 people
- Sponsor
- Bogomolets National Medical University
Obesity, Type 2 Diabetes
Longitudinal Cohort Study Comparing 2 Surgical Techniques in Patients With Class 3 Obesity and Type 2 Diabetes
Wight loss surgery provides good glycemic control in type 2 diabetes. The technique of "Roux-en-Y gastric bypass" is more effective than the "Adjustable Gastric Band" on weight loss.
- Trial name
- OBEDIAB (NCT00688974)
- Testing
- Roux-en-Y gastric bypass, Adjustable gastric band
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Obesity, Dapagliflozin Adverse Reaction
The Effect of Dapagliflozin on Weight Loss in Obese Adults Without Diabetes
The goal of this clinical trial is to examine the effectiveness of a drug named dapagliflozin (tested drug) on weight loss in young adults aged between 18 and 40 years with obesity who are not diagnosed with diabetes.
- Conditions
- Obesity, Dapagliflozin Adverse Reaction, Weight Loss, Effect of Drug
- Trial name
- DAPA-ANDO (NCT06000462)
- Testing
- Dapagliflozin 10mg Tab, Metformin 1000 mg (ttd)
- Where
- Oman
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Oman Ministry of Health
Obesity, Type 2 Diabetes Mellitus in Obese
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of K-757 and K-833 in Overweight/Obese Patients With Type 2 Diabetes
This is a multiple dose study to evaluate the safety, tolerability, PK, and PD of K-757 and K-833 when co-administered in overweight/obese patients with Type 2 diabetes mellitus (T2DM).
- Trial name
- NCT05890950
- Testing
- K-757 and K-833
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- TriGemX Bio, Inc.
Type 2 Diabetes Mellitus
A Clinical Trial to Study the Efficacy, Safety, Tolerability and Pharmacokinetics of P2202 in Patients of Type 2 Diabetes
It is a phase II, randomized, double-blind, placebo-controlled study of P2202 in patients of type 2 diabetes mellitus, inadequately controlled with a stable dose of metformin or sulfonylurea or both.
- Trial name
- NCT01674348
- Testing
- P2202
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Piramal Enterprises Limited
Type 2 Diabetes Mellitus, Overweight
Diacerein on Insulin Secretion in Diabetes
Aim. To assess the effect of interleukin 1β (IL-1β) and tumor necrosis factor α (TNFα) inhibition with diacerein administration on insulin secretion and metabolic control of drug-naïve patients with type 2 diabetes mellitus…
- Conditions
- Type 2 Diabetes Mellitus, Overweight, Obesity
- Trial name
- NCT01298882
- Testing
- Diacerein
- Where
- Mexico
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Obesity, Pre-diabetes
Chromium Effects on Insulin and Vascular Function in People at Risk for Diabetes
The purpose of this study is to investigate the effects of Chromium on glucose tolerance and endothelial function in people at risk for type II diabetes.
- Conditions
- Obesity, Pre-diabetes, Insulin Resistance, Impaired Glucose Tolerance
- Trial name
- NCT00067626
- Testing
- Chromium
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Griffin Hospital
Obesity & Overweight, Type 2 Diabetes
A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers
Phase 1 Safety and Relative Bioavailability Study of DWRX5003 in Healthy Adults
- Trial name
- NCT07539415
- Testing
- DWRX5003, DWC202502, DWC202503
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Obesity, Impaired Glucose Tolerance
Effects of Rosiglitazone on the Metabolic Phenotype of Impaired Glucose Tolerance in Youth
The purpose of the study is to determine whether treatment of children and adolescents with Impaired Glucose Tolerance (IGT) with rosiglitazone will lead to improvements in insulin sensitivity and glucose tolerance.
- Conditions
- Obesity, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT00413335
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
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