Clinical trials: Obesity in Diabetes
Diabetes
Food Intake and Appetite in the Children of Mothers With Diabetes
This protocol is for study of the effect of inhibition of parasympathetic outflow on insulin secretion and glucose metabolism. Insulin secretion will be measured during infusions of escalating doses of atropine.
- Trial name
- NCT00339313
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes, Obesity
The Curative Effect of the Length of the Jejunum Exclusion in Grstric Bypass Surgery for Type 2 Diabetes
The purpose of this study is to investigate the curative effect of the length of the jejunum exclusion in gastric surgry for T2DM and metabolic syndrome,and to draft Scientific and reasonable operation parameters.
- Trial name
- NCT02667652
- Testing
- short biliarypancreatic limb, long biliarypancreatic limb
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Weidong Tong
Type 2 Diabetes, Obesity
Extracellular Vesicles, Insulin Action, and Exercise
Extracellular vesicles (EVs) play a role in obesity-induced insulin resistance and likely impact the development of cardiovascular disease. However, little is known on how EVs affect vascular insulin action in people.
- Trial name
- NCT06546085
- Testing
- Exercise
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Overweight or Obesity
Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes
This study will test an experimental drug called olatorepatide ("study drug") to determine how safe and effective this drug is compared to placebo and how easily the body can accept this drug at different doses and dosing…
- Trial name
- NCT07685808
- Testing
- Olatorepatide
- Where
- 21 sites in United States
- Volunteers
- 360 people
- Sponsor
- Regeneron Pharmaceuticals
Obesity, Type 2 Diabetes Mellitus
Gut Microbiota in Obesity and Diabetes
An altered gut microbiota composition has recently been linked to obesity and diabetes. The principal aim of this study was to investigate and compare the gut microbiota composition of obese, diabetic and control individuals.
- Trial name
- NCT02180191
- Testing
- Comparison of the gut microbiota composition
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Obesity, Sarcopenia
Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes
The aim of TIMEDIAB is to demonstrate that early TRE (eTRE) combined to late (afternoon) exercise will outperform eTRE combined to morning exercise on muscle function as primary endpoint, and glucose homeostasis as secondary…
- Conditions
- Obesity, Sarcopenia, Post Menopause, Type 2 Diabetes
- Trial name
- TIMEDIAB (NCT07075133)
- Testing
- Antidiabetic diet (control), eTRE diet, Physical activity in the morning
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Obesity, Type 2 Diabetes Mellitus
Changes in Insulin Sensitivity After Weight Loss
This study is designed to compare the changes in insulin sensitivity as well as gastrointestinal hormone levels in diabetic and non-diabetic obese individuals who are undergoing weight loss procedures.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Insulin Resistance
- Trial name
- NCT00627484
- Testing
- Gastric bypass, Gastric banding, Sleeve gastrectomy
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Columbia University
Type 2 Diabetes, Depression
Learning to BREATHE: A Randomized Controlled Trial to Lower Diabetes Risk in Adolescent Girls
Type 2 diabetes is a chronic disease that puts people at risk for major health problems like heart disease. Type 2 diabetes is the most common type of diabetes in adults.
- Conditions
- Type 2 Diabetes, Depression, Obesity
- Trial name
- NCT02218138
- Testing
- Learning 2 BREATHE, Colorado Blues
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Obesity, Diabetes
Residual Gastric Volume in Morbidly Obesa Diabetics. A Comparison of 3 Hour Versus Hour Fasting.
To reduce the risk of aspiration for elective procedures, residual gastric volumes (RGV) have traditionally been minimized with overnight fasting.
- Conditions
- Obesity, Diabetes, Fasting
- Trial name
- NCT02114008
- Testing
- Endoscopic examinations
- Where
- Brazil
- Volunteers
- 8 people
- Sponsor
- Cuiaba University
Overweight, Obesity
Effect of High Monounsaturated Fat Diet on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes
The purpose of this proposed randomized, controlled trial is to compare the effects of high monounsaturated fat diets and high carbohydrate diets on body weight, body composition, glycemic control, plasma lipids, and other…
- Conditions
- Overweight, Obesity, Type 2 Diabetes
- Trial name
- NCT00622960
- Testing
- High-MUFA diet, High-CHO diet
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Cincinnati
Diabetes, Diabetes Mellitus, Type 1
Observational Study on Levemir® in Obese Diabetic Patients
This study is conducted in Europe. The aim of this observational study is to investigate the effect of switch from other basal insulin treatments to Levemir® on body weight in obese diabetic patients.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- KILOS (NCT00849342)
- Testing
- insulin detemir
- Where
- 2 sites in Netherlands, Slovenia
- Volunteers
- 580 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus
Investigate the Efficacy and Safety of GSK1070806 in Obese Subjects With T2DM
GSK1070806 is a humanised IgG1/kappa antibody which is directed against the soluble cytokine interleukin-18 (IL-18). The aims of this placebo controlled study are to evaluate the efficacy, safety, tolerability, pharmacokinetics…
- Trial name
- T2DM (NCT01648153)
- Testing
- GSK1070806
- Where
- 13 sites in Spain, United Kingdom
- Volunteers
- 37 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2, Obesity
Influence of a Liquid Oat Bran Product on Blood Glucose in Patients With Poorly Controlled Type 2 Diabetes
This study evaluates the effects of an ad libitum addition of a high fiber product to the regular diet of type 2 diabetes patients on body weight and blood sugar control.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Overweight, Metabolic Syndrome
- Trial name
- NCT03805802
- Testing
- active product, reference product
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Stoffwechselzentrum Rhein - Pfalz
Type 2 Diabetes Mellitus, Obesity
Macrovascular and Microvascular Morbidity and Mortality After Metabolic Surgery Versus Medicines
The goal of this study is to compare the impact of metabolic surgery and a class of anti-diabetes medications (Glucagon-like peptide-1 receptor agonists,GLP-1 RAs) on occurrence of diseases involving small and large vessels such…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Microvascular Disease, Macrovascular Disease
- Trial name
- M6 (NCT06355219)
- Volunteers
- 3,932 people
- Sponsor
- Ali Aminian
Overweight, Obesity
Mobile Exergaming in Type 2 Diabetes
The purpose of this study is to investigate if MOBIGAME (an innovative, mobile phone-based game application) is suitable to increase daily physical activity and physical activity adherence as well as health parameters such as…
- Conditions
- Overweight, Obesity, Diabetes Mellitus, Type 2
- Trial name
- MOBIGAME (NCT02657018)
- Testing
- MOBIGAME, Control
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Basel
Overweight, Obesity
PROTeIn-rich Meals to Control Glucose
The overall aim is to identify the dietary pattern for prevention and treatment of type 2 diabetes. The specific aim of this pilot project is to compare effects of two diets with different diurnal distribution of carbohydrates…
- Conditions
- Overweight, Obesity, Prediabetes, Type 2 Diabetes
- Trial name
- PROTIME (NCT06382480)
- Testing
- Diet with specific macronutrient composition.
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- German Institute of Human Nutrition
Obesity
A 1-Year Study On The Effects Of CP-945,598 For The Treatment Of Obesity In Overweight Type 2 Diabetic Patients
The purpose of this study is to determine if CP-945,598 is effective in the treatment of obesity in type 2 diabetic patients.
- Trial name
- NCT00391196
- Testing
- CP-945,598, CP-945,598 Treatment B
- Where
- 91 sites in United States, Argentina and 9 more
- Volunteers
- 975 people
- Sponsor
- Pfizer
Severe to Morbid Obesity and Type 2 Diabetes
Study of Weight Loss Using Gastric Stimulation in Obese Patients With Type 2 Diabetes
The purpose of this study is to test the effect of an implanted device that stimulates the stomach on weight loss in patients suffering from obesity and type 2 diabetes.
- Trial name
- ASSIST (NCT00200018)
- Testing
- Enterra Therapy System (H9900014)
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- MedtronicNeuro
Obesity, Diabetes Mellitus, Type 2
Efficacy of Self-hypnosis for Weight Loss in Type 2 Diabetics
Randomized study evaluating self-hypnosis versus certified diabetes educator training for weight loss in type 2 diabetics.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Weight Reduction
- Trial name
- NCT02769585
- Testing
- Self-hypnosis, CDE training
- Volunteers
- 74 people
- Sponsor
- Levenson, David I., M.D.
Obesity, Childhood, Weight Change, Body
Feasibility of the Camp Power Up Program on Children's Body Weight and Quality of Life
This study will evaluate the effects of a one week weight management summer camp on children's weight, quality of life, mood and feelings, self-esteem, weight management efficacy, enjoyment of physical activity, and body image.
- Conditions
- Obesity, Childhood, Weight Change, Body, Quality of Life
- Trial name
- CampPowerUp (NCT03235440)
- Testing
- Kids N Fitness Program
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
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