Clinical trials: Obesity in Men, active
Prostate Cancer
Whole-Food Plant-Based Diet to Control Weight and MetaboInflammation in Overweight/Obese Men With Prostate Cancer
The study is comparing the effect on weight of providing home-delivered whole-food, plant-based meals versus standard, general nutritional counseling to men with prostate cancer on androgen-deprivation therapy (ADT).
- Trial name
- WFPBD (NCT05471414)
- Testing
- Whole-food, Plant-Based Diet, General Nutritional Counseling
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Weill Medical College of Cornell University
Obesity, Weight Loss
Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program
Men in the United States have an exceptionally high prevalence of overweight and obesity, i.e., 71.3%, and 42% of men are currently attempting weight loss. However, men are dramatically underrepresented in weight loss programs.
- Trial name
- NCT05408494
- Testing
- Gamified behavioral weight loss treatment, mHealth behavioral weight loss treatment
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Drexel University
Normal-weight Obesity
The Interaction of Body Composition, Sex Hormones and Exercise in Men
The overall objective of this project is to advance understanding of the causes of normal weight obesity (NWO) in men, namely the hormone profile and related potential mediating mechanisms, and the efficacy of different modes of…
- Trial name
- AHA-NWO (NCT06970457)
- Testing
- Resistance Exercise Training, Aerobic Exercise Training
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Fatty Liver, Overweight/Obesity
Effects of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Overweight/Obese Men With T2DM or Prediabetes and Hypogonadism
The epidemics of obesity, MeTSy, T2DM and CVD are increasing worldwide. Non-alcoholic fatty liver disease (NAFLD) is becoming recognized as a condition possibly involved in the pathogenesis of these diseases.
- Conditions
- Fatty Liver, Overweight/Obesity, Prediabetes/Type2 Diabetes Mellitus, Hypogonadism, Male
- Trial name
- Test2Func (NCT03851627)
- Testing
- Testosterone Undecanoate
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Alexandra Kautzky-Willer
Healhty, Overweight or Obesity
Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BGM1812 Injection Following Single and Multiple Subcutaneous Administration in Normal to Overweight or Obese But Otherwise Healthy Men and Women
This is a Phase 1, single-center, double-blind, placebo-controlled, dose-escalation study. The study will evaluate the pharmacokinetics (PK), pharmacodynamic (PD), preliminary efficacy, safety and tolerability of BGM1812…
- Trial name
- NCT07224399
- Testing
- BGM1812
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BrightGene Bio-Medical Technology Co., Ltd.
Prostate Cancer, Metabolic Syndrome
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
The overriding objectives of this study are: 1. Primary outcomes: 1. To confirm that administration of oral acetate increases the proportion of A.
- Conditions
- Prostate Cancer, Metabolic Syndrome, Obesity, Cardiovascular Morbidity
- Trial name
- NCT05802121
- Testing
- Apple Cider Vinegar
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Western University
Obesity, Bariatric Surgery Candidate
Impact of Weight Loss Induced by Bariatric Surgery or Nutritional Management on Sexual Function in Men With Severe Obesity
Study of the impact of weight loss induced by surgery (interventional group) or optimal nutritional management (control group) on sexual function in men with severe obesity
- Trial name
- SexOb (NCT03528980)
- Where
- 3 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Lille
Osteoarthritis, Knee
WATERinMOTION Aquatic Therapy in Obese Men With Knee Osteoarthritis
This RCT evaluates whether WATERinMOTION aquatic therapy improves pain, function, and quality of life more effectively than land-based exercise in obese men with knee osteoarthritis (OA).
- Conditions
- Osteoarthritis, Knee, Obesity
- Trial name
- WATERinMOTION (NCT06946329)
- Testing
- Aquatic Exercise, Land-Based Rehabilitation
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- University of Sistan and Baluchestan
Obesity-related Male Infertility
Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health
Why is this study being done? Obesity can harm men's fertility by lowering sperm quality and hormone levels, making it harder to have children. Weight loss through diet and exercise helps, but it's often hard to stick with.
- Trial name
- NCT07179120
- Testing
- Semaglutide (Rybelsus®), Tirzepatide, Standardized Lifestyle Intervention
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Healthy Lifestyle, Obese
Project 1: Diet and Exercise Modulate the Sperm Epigenome in Men
This is a rigorous, controlled clinical trial designed to show that diet, exercise training, and their combination in overweight, inactive men will alter epigenetic programming to create a "healthy" sperm epigenome.
- Conditions
- Healthy Lifestyle, Obese, Men
- Trial name
- NCT04175678
- Testing
- Diet, Exercise, Standard care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Insulin Resistance, Obesity
Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity
Background: Obesity and related illnesses cause at least 2.8 million deaths each year worldwide. Few treatments exist for obesity that are safe and widely available.
- Trial name
- NCT05713799
- Testing
- Alpha-lipoic acid, Mirabegron
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hypertension
Effects of Combined High Intensity Interval Training and Resistance Training
Background: Hypertension has long been considered as a major risk factor for cardiovascular disease representing a high public health concern.
- Trial name
- Hypertension (NCT06845436)
- Testing
- Exercise, routine physical activity
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Adult Male
Effect of Early Time-Restricted Eating on Appetite, Appetite-Regulatory Hormones and Energy Intake
This randomised crossover study's primary aim is to investigate the effect of short-term fasting (eTRE) on subjective appetite and appetite-regulatory hormones (i.e., leptin, adiponectin, total glucagon-like peptide-1 (GLP-1)…
- Trial name
- NCT07500792
- Testing
- Normal diet, early Time-Restricted Eating (eTRE), instantaneous visual analogue scale (iVAS)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Fasting, Obesity (BMI>30)
The Effect of Fasting on Peak Fat Oxidation, Mitochondrial Coupling and Extracellular Matrix
The interventional study will recruit four groups (n=10 per group): Young men and women with normal weight (BMI 18-25), and young men and women with obesity (BMI >30).
- Conditions
- Fasting, Obesity (BMI>30), Sex Difference
- Trial name
- GlycoFast84 (NCT07692646)
- Testing
- Diet
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
Investigating the Effects of the "GameDay Ready" Behavioral Weight Management Program for Black Men Living in the Rural South
This pilot study investigates the effects of a newly developed 12-week weight management program called "GameDay Ready" (compared to a walking and general health education program) for decreasing body weight among Black men who…
- Trial name
- NCT05970042
- Testing
- GameDay Ready, Walking and General Health Education
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Obesity & Overweight
A Phase 2A Clinical Trial to Assess the Safety and Tolerability of ERX1000 in Men and Women for the Treatment of Obesity.
The primary objective is to assess the safety and tolerability of oral dose ERX1000 in obese subjects.
- Trial name
- NCT07570758
- Testing
- ERX1000
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- ERX Pharmaceuticals
Bariatric Surgery, Bone Health
Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women
Background: Bariatric surgery is gaining in popularity. While it's health benefits are undisputed, the older malabsorptive bariatric procedures (Roux-in-Y gastric bypass - RYGB and biliopancreatic diversion - BPD) are associated…
- Conditions
- Bariatric Surgery, Bone Health, Severe Obesity, Muscle Health
- Trial name
- BONUS (NCT06547515)
- Testing
- Bariatric surgery
- Where
- Canada
- Volunteers
- 156 people
- Sponsor
- CHU de Quebec-Universite Laval
Obesity, Morbid, Intubation; Difficult or Failed
Comparison of Airtraq in Class 2-3 Obese and Nonobese Men During Intubation: a Prospective Randomized Clinical Study
Morbid obesity is a growing disease. Intubations of these patients mostly difficult. Video laryngoscopes have to be used during the intubation of these patients.
- Conditions
- Obesity, Morbid, Intubation; Difficult or Failed, Video Laryngoscope, Men
- Trial name
- NCT05927519
- Testing
- airtraq video laryngoscope
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kocaeli University