Clinical trials: Obesity in Pregnancy
Obesity, Gestational Diabetes
Impact of Diet and Exercise Activity on Pregnancy Outcomes
The general goal of the present study is to assess the impact of a community-based exercise and dietary intervention in pregnant women living in urban areas during and after their pregnancy on the reduction of the risks of both…
- Conditions
- Obesity, Gestational Diabetes, Type 2 Diabetes
- Trial name
- IDEA (NCT00486629)
- Testing
- Exercise and dietary education
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Gestational Diabetes Mellitus (GDM), Pregnancy
Gestational Diabetes and Health Outcomes in Mothers and Babies
Gestational diabetes mellitus (GDM) is a common pregnancy complication characterized by impaired glucose metabolism and increased insulin resistance.
- Trial name
- GRAZ-GDM (NCT07459907)
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Graz
Endometrial Cancer
Adipocytokines in Endometrial Cancer
Endometrial cancer incidence rates were increasing in the past two decades with a continuous rising trend in Taiwan. Uterine cancer was attributable to obesity based on their association with excess body weight in most…
- Trial name
- ACEmCa (NCT05018195)
- Testing
- Excise adipose tissue
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Obesity
Partners in Health: A Couples-based Approach to Obesity Prevention
The purpose of this pilot study is to test the feasibility of an innovative, couples based approach to weight management during pregnancy.
- Trial name
- PIH (NCT02205281)
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Infertility, Female
The Impact of Body Mass Index on the Endometrial Microbiome in IVF Treatments. Tampere Infertility Microbiome Project (TIMP).
This study project is an observational trial involving 90 patients suffering from male type infertility. The patients are divided in two groups (45 patients per group) based on their body mass index (BMI).
- Trial name
- NCT04168567
- Testing
- Microbiome analysis
- Where
- Finland
- Volunteers
- 91 people
- Sponsor
- Tampere University Hospital
Polycystic Ovary Syndrome
Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS)
The goal of this clinical trial is to compare the effect of Semaglutide and metformin on weight loss in obese women with Polycystic Ovarian Syndrome (PCOS) over a 28-week treatment period.
- Trial name
- NCT05646199
- Testing
- Metformin, Semaglutide Injectable Product
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Hull
Glucose Intolerance, Obesity
The Snack Study: The Feasibility of Changing Night-time Food Choices to Improve Glucose Tolerance in Pregnancy
Obesity during pregnancy increases the risk for high glucose and diabetes in the mother, and for obesity and comorbid metabolic disease in the offspring.
- Trial name
- NCT02634593
- Testing
- Low glycemic load snacks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Obesity, Pregnancy
Maternal Body Mass Index and Anovaginal Distance
The hypothesis was that the anovaginal distance (AVD), defined as the distance between the anal mucosa and the vaginal wall at the middle level of the anal canal, is higher in obese women compared with normal weight women.
- Trial name
- AVD (NCT03149965)
- Testing
- transperineal ultrasound
- Volunteers
- 207 people
- Sponsor
- Linkoeping University
Diabetes Mellitus
Preventing Renal Functional Abnormalities With Calorie Restriction in Subjects With Abdominal Obesity and Type 2 Diabetes at Increased Renal and Cardiovascular Risk
The study investigates whether a caloric restricted dietary regime can prevent onset and/or progression of chronic kidney disease in type 2 diabetic patients with abdominal obesity, through the amelioration of concomitant…
- Trial name
- CRESO (NCT01213212)
- Testing
- Caloric restriction, No intervention
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Gestational Diabetes, Diabetes
Lifestyle Modification to Improve Diet in Women With GDM
The study aims to adapt a lifestyle modification program to engage GDM women early in the postnatal period to evaluate its effectiveness in reducing adiposity and metabolic parameters in the mother.
- Conditions
- Gestational Diabetes, Diabetes, Childhood Obesity, Diabetes Mellitus
- Trial name
- NCT03669887
- Testing
- Lifestyle Modification Program
- Where
- Hong Kong
- Volunteers
- 103 people
- Sponsor
- Chinese University of Hong Kong
Pre-Eclampsia, Obesity
Weight Loss Following an Episode of Pre-eclampsia Using a Dissociated or Hypocaloric Diet in Overweight or Obese Patients
In view of the known link between pre-eclampsia, overweight/obesity and chronic kidney disease, the aim is to offer for obese and overweight patients to reduce their BMI without reducing lean body mass.
- Trial name
- POPADIPE (NCT06067906)
- Testing
- Hypocaloric diet, Dissociated diet
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier le Mans
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Obesity, Myelomeningocele
Extended Criteria For Fetal Myelomeningocele Repair
The purpose of this study is to offer pre-natal Myelomeningocele (MMC) repair surgery to pregnant women with one of the former surgery exclusion factors A BMI of 35-40 kg/m2 Diabetes; patients will require good glycemic control…
- Conditions
- Obesity, Myelomeningocele, Pregnancy, Diabetes Mellitus in Pregnancy
- Trial name
- NCT02664207
- Testing
- Open Fetal Repair of Myelomeningocele
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anovulation, Obesity
Weight Reduction Surgery and Ovarian Function
This study will investigate the role of weight reduction surgery on the reproductive performance of obese women with ovulation problems.
- Trial name
- NCT00292773
- Testing
- weight reduction minimal access surgery
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Obesity, Obesity, Maternal
Obesity and OSA in Pregnancy
The purposes of this project are 1) to compare the impact of maternal obesity versus excessive gestational weight gain on obstructive sleep apnea (OSA) in obese and non-obese women; 2) to investigate the mechanism(s) by which…
- Conditions
- Obesity, Obesity, Maternal, Obstructive Sleep Apnea, Blood Pressure
- Trial name
- NCT05654259
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- University of Texas Southwestern Medical Center
Polycystic Ovary Syndrome, Obesity
Effects of GLP-1RAs on Reproductive Outcomes in PCOS and Obesity
The goal of this clinical trial is to examine whether benalutide combined with metformin and healthy lifestyle education in women with PCOS and obesity prior to fertility treatment improves live birth rate and other reproductive…
- Conditions
- Polycystic Ovary Syndrome, Obesity, Infertility, Female
- Trial name
- NCT06775093
- Testing
- GLP-1 receptor agonist, Metformin, healthy lifestyle education
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Peking University Third Hospital
Maternal Obesity
Balloon to Induce Labor in Generous Women.
The rate of obesity increases continuously in France as in many developing countries.The risk of cesarean delivery is increased in obese compared to normal-weight women and postpartum complications as infections, thromboembolic…
- Trial name
- BIGW (NCT03435458)
- Testing
- Balloon catheter + oral misoprostol, Oral misoprostol alone
- Where
- 18 sites in France, Martinique
- Volunteers
- 429 people
- Sponsor
- University Hospital, Toulouse
Obesity
Reducing Obesity in Underserved Postpartum African American Women
In this proposal, the investigators will develop a culturally-tailored, 8-week clinic-based weight loss program to reduce obesity among postpartum African American (AA) adult women that can be integrated into a postpartum care…
- Trial name
- RENEW (NCT02448563)
- Testing
- Nutrition and physical activity education
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Obesity, Type 2 Diabetes
Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women
In this study, we will clarify the degree of insulin resistance and characterise muscle glucose metabolism and gene expression in a group of overweight healthy women.
- Conditions
- Obesity, Type 2 Diabetes, Polycystic Ovary Syndrome
- Trial name
- NCT00145392
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Anesthesia, Obstetrical
Subarachnoid Bupivacaine in Obese Patients Undergoing Cesarean Delivery
This study evaluates the effect of subarachnoid hyperbaric bupivacaine on mean arterial blood pressure (MAP) of pregnant patients with obesity undergoing cesarean section half of the patients will receive subarachnoid hyperbaric…
- Trial name
- NCT04205344
- Testing
- Bupivacaine 5 mg, Bupivacaine 10 mg
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital Civil de Guadalajara