Clinical trials: Obesity in Pregnancy
Chronic Kidney Failure
Exercise for Chronic Kidney Diseases
PURPOSE: To compare between the effect of aerobic exercise and resistance exercises on patients with obese chronic kidney diseases.
- Trial name
- NCT04522115
- Testing
- exercises
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
PCOS (Polycystic Ovary Syndrome)
Fecal Microbiota Transplantation for Obese Women With Polyendocrine Metabolic Ovarian Syndrome
This prospective, two-stage clinical trial aims to evaluate the safety, preliminary efficacy, and reproductive outcomes of oral Fecal Microbiota Transplantation (FMT) freeze-dried capsules in overweight and obese patients with…
- Trial name
- FMT-PMOS (NCT07746635)
- Testing
- oral Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 201 people
- Sponsor
- Shanghai Changzheng Hospital
Diabetes, Gestational, Dietary Modification
Dietary Management of Gestational Diabetes in Obese Pregnant Women
eMOM is a randomized, controlled trial to compare the effects of two different dietary interventions during pregnancy. The comparison is based on tissue glucose content (using continuous glucose monitoring system) in pregnant…
- Conditions
- Diabetes, Gestational, Dietary Modification, Tissue Glucose, Body Composition
- Trial name
- eMOM (NCT03542071)
- Testing
- Carbohydrate restricted diet, Plant-protein based diet
- Where
- Finland
- Volunteers
- 2 people
- Sponsor
- Helsinki University Central Hospital
PCOS (Polycystic Ovary Syndrome), Insulin Resistance
Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder frequently associated with obesity, insulin resistance (IR), and metabolic dysfunction.
- Conditions
- PCOS (Polycystic Ovary Syndrome), Insulin Resistance, Obesity (BMI>30)
- Trial name
- NCT07770711
- Testing
- Metformin, İnositol, Folic Acid
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dicle University
Obesity, Pregnancy Related
Combined Spinal Epidural Anesthesia in Obese Patients Undergoing Cesarean Surgery
This study investigated the maternal and fetal effects during performance of CSEA in the left lateral decubitus and sitting positions in obese pregnant women undergoing elective cesarean section.
- Conditions
- Obesity, Pregnancy Related, Cesarean Section Complications, Spinal Anaesthetic Poisoning of Undetermined Intent
- Trial name
- NCT04612998
- Testing
- left lateral decubitus position, sitting position, The use of intravenous ephedrine.
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Urologic Diseases, Overactive Bladder Syndrome
Central Obesity in Cases of OAB
Obesity is not a homogeneous condition and that the regional distribution of adipose tissue is important to understanding the relation of obesity to disturbances in glucose and lipid metabolism.
- Conditions
- Urologic Diseases, Overactive Bladder Syndrome, Obesity, Abdominal
- Trial name
- NCT03750604
- Testing
- visceral fat obesity (surface area and function)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Gestational Weight Gain
Study of a Randomized Intervention Designed to Increase Exercise in Pregnancy
This project aims to determine whether a mobile-health (m-health) tool, accessible via smartphone or website, intervention for overweight and obese pregnant women improves physical activity, gestational weight gain, quality of…
- Trial name
- STRIDE (NCT03936283)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Kaiser Permanente
Renal Stones
Postoperative Outcomes of PCNL vs RIRS in Obese Patients With Pelvic 1.5:3 cm Renal Stones
This prospective randomized comparative study was done at Helwan University Hospital. It was conducted on 120 patients with unilateral pelvic renal stones from 1.5 to 3 cm in largest diameter who was admitted through duration to…
- Trial name
- PCNL VS RIRS (NCT06175910)
- Testing
- percutaneous nephrolithotomy, retrograde intrarenal surgery
- Where
- Egypt
- Volunteers
- 182 people
- Sponsor
- bassem metwally
Preeclampsia, Postpartum Period
The PreEclampsia Postpartum Prevention Trial
The goal of this clinical trial is to learn if a postpartum bundle intervention can improve cardiometabolic health and lifestyle-related factors in women who have had preeclampsia during their first pregnancy.
- Conditions
- Preeclampsia, Postpartum Period, Hypertension, Cardiovascular Diseases
- Trial name
- PEPP (NCT07199283)
- Testing
- Bundle Intervention
- Where
- 2 sites in Sweden
- Volunteers
- 356 people
- Sponsor
- Karolinska Institutet
Blood Pressure
Oral L-Citrulline and ADMA in Pregnancy
The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks provided in mid-pregnancy to obese subjects will decrease the plasma ADMA/L-arginine ratio, lower maternal blood pressure, improve…
- Trial name
- NCT00743210
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Polycystic Ovary Syndrome
Adipose Expression of Leptin, Adiponectin and IL-6 and Plasma Levels of Adipocytokines in Women With and Without Polycystic Ovary Syndrome (PCOS)
The purpose of the study was to investigate adipose expression and plasma levels of different adipocytokine, which may play a role in the pathophysiology of PCOS.
- Trial name
- NCT01088061
- Where
- Denmark
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Diabetes Mellitus, Intrahepatic Cholestasis of Pregnancy
Magnetic Resonance Imaging and Thermal Imaging of Adiposity in Neonates of Women With Metabolic Diseases
There is limited knowledge about the extent of the impact of maternal metabolic diseases (MD) and/or alterations in maternal serum lipid content upon neonatal lipid distribution and phenotypes.
- Conditions
- Diabetes Mellitus, Intrahepatic Cholestasis of Pregnancy, Metabolic Disease
- Trial name
- MRI-TIME (NCT04890886)
- Testing
- Thermal imaging, Echocardiogram, ECG
- Volunteers
- 80 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cardiac Performance
Cardiac Performance in Pregnant Obese Women:Are They in Jeopardy?
The aim of this work is to Assess serial changes in "cardiovascular function" in morbidly obese pregnant females (BMI equal or higher than 30 kg/m2) as compared to normal lean pregnant female controls.
- Trial name
- NCT02436343
- Testing
- echocardiogram
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Benha University
Labor, Induced, Obesity
Misoprostol for Induction of Labor in Obese Women: Comparison Between 25 and 50 mcg Oral Administration
In recent decades, obesity has become a prevalent issue in Portugal, with 38.6% and 13.8% of the population being overweight or obese, respectively.
- Conditions
- Labor, Induced, Obesity, Pregnancy, Cesarean Section
- Trial name
- NCT05857059
- Testing
- Misoprostol 25 mcg, Misoprostol 50 mcg
- Where
- Portugal
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Pre Diabetes, Polycystic Ovary Syndrome
Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
There is a growing need to develop pharmacologic interventions to improve metabolic function in women with polycystic ovary syndrome (PCOS).
- Conditions
- Pre Diabetes, Polycystic Ovary Syndrome, Obesity Android
- Trial name
- SAXAPCOS (NCT03480022)
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Woman's
Food Allergy
Effect of Mediterranean Diet During Pregnancy on the Onset of Overweight and Obesity in the Offspring
The first 1,000 days of life, from the conception to 24 months, are crucial to achieve long-term health outcomes and represent a strategic period to intervene under prevention and public health perspective.
- Trial name
- PREMEDI (NCT03337802)
- Testing
- mediterranean diet
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
Girls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss…
- Trial name
- RESTORE (NCT05819853)
- Testing
- Semaglutide Injectable Product (Wegovy and/or Ozempic)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Obesity & Overweight, Diabetes Mellitus, Type 2
Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks
This is a nationwide, multi-center, long-term follow-up study of overweight and obese adults in China. The study aims to recruit approximately 26,000 participants across 39 hospitals to better understand how body weight affects…
- Conditions
- Obesity & Overweight, Diabetes Mellitus, Type 2, Hypertension, Non-alcoholic Fatty Liver Disease (MASLD)
- Trial name
- NCT07884903
- Testing
- No intervention; observational assessment only
- Where
- China
- Volunteers
- 25,974 people
- Sponsor
- Shanxi Bethune Hospital
Polycystic Ovary Syndrome (PCOS), Overweight
The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS
Polycystic ovary syndrome (PCOS) is a health problem that affects one in 10 women of childbearing age, which is usually characterized by hormonal imbalance and metabolism problems such as hyperandrogenism and obesity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Overweight, Obesity
- Trial name
- NCT03151005
- Testing
- Metformin-GLP-1 Receptor Agonist, Metformin-Oral Contraceptive(OC)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xinqiao Hospital of Chongqing
End Stage Renal Disease, Renal Impairment
A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide
The primary objective of the study is to estimate the PK parameters of ribupatide in participants with severe renal impairment or end-stage kidney disease (ESKD) after a single dose of ribupatide subcutaneous (SC) injection…
- Conditions
- End Stage Renal Disease, Renal Impairment, Obesity, Overweight
- Trial name
- NCT07793929
- Testing
- Ribupatide
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kailera